Trelagliptin Succinate Intermediate CAS 865759-24-6 daahirnimo>98.0% (HPLC)

Sharaxaad Gaaban:

Trelagliptin Succinate Intermediate-int D

CAS: 865759-24-6

Daahirsanaanta:>98.0% (HPLC)

Muuqashada: Caddaan-ka-baxsan ilaa Nalalka Jaallaha ah

Dhexdhexaadiyaha Trelagliptin Succinate (CAS: 1029877-94-8) ee daawaynta Nooca 2aad ee Sonkorowga

Xiriirka: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Sharaxaad:

Sahayda Ganacsiga ee Trelagliptin Succinate Dhexdhexaadinta La Xidhiidha:
6-Chloro-3-Methyluracil CAS 4318-56-3
2-Cyano-5-Flurobenzyl Bromide CAS 421552-12-7
(R)-(-)-3-Aminopperidine Dihydrochloride CAS 334618-23-4
Trelagliptin Succinate Intermediate-int D CAS 865759-24-6
Trelagliptin Succinate CAS 1029877-94-8
Please contact: alvin@ruifuchem.com

Guryaha Kiimikada:

Magaca Kiimikada	Trelagliptin Succinate Intermediate-int D
La mid ah	2-((6-Chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile;2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-4-fluorobenzonitrile
wasakhnimo	Trelagliptin wasakhda 17
Heerka Saamiyada	Suuqa dhexdiisa, Miisaanka Ganacsiga
Lambarka CAS	865759-24-6
Qaanuunka molecular	C13H9ClFN3O2
Miisaanka Molecular	293.68 g/mol
Cufnaanta	1.49±0.10 g/cm3
Heerkulka Kaydinta	Qabow & Meel Qalalan
COA & MSDS	La heli karo
Summada	Kiimikada Ruifu

Tilmaamaha:

Walxaha	Heerarka Kormeerka	Natiijooyinka
Muuqashada	Ka-baxa Cad-cadaan ee Jaallaha ah	waafaqsan
Aqoonsiga
HPLC	Waqtiga haynta ee muunadda tijaabada ugu sarreysa waxay u hoggaansantaa heerka tixraaca	waafaqsan
IR - Spectrum infrared	IR nuugista spectra muunad iyo halbeeggu waa is waafaqsan yihiin	waafaqsan
Kormeer
Khasaare xagga qalajinta	<0.50%	0.3%
Wadarta wasakhda	<2.00%	waafaqsan
Daahirnimada / Habka Falanqaynta	>98.0% (HPLC)	99.1%
Gabagabo	Alaabta waa la tijaabiyay oo waafaqay qeexitaannada

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FAQ:

Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.

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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.

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Codsiga:

2-((6-chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile (CAS: 865759-24-6) waxaa loo isticmaalaa sida dhexe ee Trelagliptin Succinate (CAS: 1029877-94-8).Trelagliptin Succinate, oo ay soo saartay Takeda, Japan, oo la bilaabay March 2015, iyada oo hoos imanaysa magaca ganacsiga Zafatek, ayaa loo isticmaalaa daaweynta nooca 2 ee sonkorowga.Trelagliptin waa dipeptidyl peptidase IV(DPP-4) inhibitor ah oo dhaq-dhaqaaqa aadka u-dheer ah iyadoo si is-xukun ah oo joogto ah u joojinaysa DPP-4 si loo xakameeyo heerarka sonkorta dhiigga.Trelagliptin waa daawada hypoglycemic toddobaadle ah ee ugu horreysa ee suuqa, iyo kuwa la midka ah ee DPP-4 inhibitors ee suuqa ayaa loo baahan yahay in la qaato hal mar maalintii.Faa'iidooyinka dawada Zafatek waxay shaki la'aan siin doontaa ikhtiyaaro daaweyn oo ku habboon bukaannada sonkorowga qaba.Waxaa la filayaa inay si weyn u wanaajiso ku habboonaanta iyo u hoggaansanaanta bukaanka.Maarso 26, 2015, shirkadda weyn ee dawooyinka Japan ee Takeda ayaa ku dhawaaqday in dawada cusub ee sonkorowga Zafatek ay ansixisay Wasaaradda caafimaadka, shaqada iyo daryeelka ee Japan (MHLW) si loogu daweeyo nooca 2 ee sonkorowga.Oggolaanshaha ayaa calaamad u ah Zafatek inuu noqdo dawada hypoglycemic afka ee toddobaadlaha ah ee ugu horreysa suuqa adduunka, iyo sidoo kale waxay ka dhigan tahay xannibaad ay Takeda ku ridday suuqa sonkorowga.
Trelagliptin waa inhibitor dipeptidyl peptidase IV (DPP-4) todobaadkiiba hal mar kaas oo koontaroolaya heerarka sonkorta dhiigga iyada oo xulashada iyo si joogto ah u joojinaya DPP-4.DPP-4 waa enzim kaas oo bilaabi kara kicinta incretin (glucagon-like peptide-1 (GLP-1) iyo insulinotropic polypeptide-ku-tiirsan (GIP)), kuwaas oo door muhiim ah ka ciyaara xakamaynta gulukooska dhiigga.Joojinta DPP-4 waxay kordhin kartaa heerka sonkorta dhiigga ee ku-tiirsanaanta insulin-ku-tiirsanaanta, sidaas awgeed waxay xakameynaysaa heerka sonkorta dhiigga.Soo gudbinta Trelagliptin NDA waxay ku salaysan tahay waxtarka iyo xogta badbaadada ee dhowr waji oo tijaabo caafimaad ah oo lagu sameeyay bukaannada Japan ee qaba nooca 2 ee sonkorowga.Waxtarka Trelagliptin ayaa lagu xaqiijiyay dhammaan tijaabooyinka, waxayna leedahay badbaado iyo dulqaad wanaagsan.Maamulka Trelagliptin todobaadkiiba hal mar ayaa si wax ku ool ah u xakameyn kara heerka sonkorta dhiigga waxaana la filayaa inuu wanaajiyo u hoggaansanaanta daawada bukaanka.