Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee (R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00). -3) oo leh tayo sare, dhexdhexaad ah Crizotinib (CAS: 877399-52-5).Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Crizotinib Dhexdhexaad,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| La mid ah | Dhexdhexaadiyaha Crizotinib;Crizotinib Bromide wasakhnimo;5-Bromo-3-[(1R) -1- (2,6-Dichloro-3-Fluorophenyl) ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl] amin |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 877399-00-3 |
| Qaanuunka molecular | C13H10BrCl2FN2O |
| Miisaanka Molecular | 380.04 g/mol |
| Meesha dhalaalaysa | 108.0 ilaa 113.0 ℃ |
| Cufnaanta | 1.643 |
| COA & MSDS | La heli karo |
| Tusaale | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Crizotinib (CAS: 877399-52-5) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Jaalle fudud ilaa budada jaalaha ah ilaa Crystal | U hogaansama |
| Meesha dhalaalaysa | 108.0 ilaa 113.0 ℃ | U hogaansama |
| Daahirnimada (HPLC Aagga) | ≥98.0% | 99.1% |
| Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtan waa la tijaabiyay oo waafaqay tilmaamaha | |
| Nolosha shelf | 2 Sano Hadii Si Wanaagsan Loo Dhigo | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
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(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) waxaa loo isticmaalaa sidii dhexdhexaad ah Crizotinib (CAS: 877399-52-5).
Crizotinib xaqiiqdii waa dawada ka hortagga kansarka oo noqota alk (anaplastic lymphoma kinase) iyo ros1 (c-ros oncogene 1) inhibitor, oo loo oggolaaday daawaynta qaar ka mid ah kansarka sambabada unugyada yaryar (NSCLC) ee Maraykanka iyo qaar ka mid ah wadamada kale, iyo Maraya daraasado badan oo tijaabinaya badbaadada iyo waxtarkeeda ee lymphoma unug weyn ee anaplastic, neuroblastoma, iyo burooyinka kale ee adag ee horumarsan ee dadka waaweyn iyo carruurta.
Crizotinib waa daawaynta la beegsanayo ee kansarka sambabada unug yar oo ay samaysay Pfizer, USA.Waxaa loo ansixiyay suuqgeynta gudaha Mareykanka Agoosto 2011 waxaana lagu qoray tilmaamaha daawaynta kansarka sambabada caalamiga ah dhamaadka sanadka sida dawada safka kowaad ee bukaanada ALK-positive ah.La-ansixiyey Crizotinib waa habka ugu horreeya ee ogaanshaha hidda-socodka iyadoo la adeegsanayo fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, kani waa habka hadda loo isticmaalo tijaabooyinka caafimaad ee caalamiga ah si loo ogaado EML4-ALK hiddo-wadaha isku-dhafka ah ee NSCLC.Tijaabadani waxay kaa caawin doontaa in la ogaado bukaanada laga yaabo inay ka faa'iidaystaan daaweynta Crizotinib.
Crizotinib waa tyrosine kinase reseptor inhibitor oo la xushay oo loo isticmaalo daawaynta kiisaska la xushay ee kansarka sambabada unugyada aan yarayn.Waa dual ATP tartanka inhibitor ee tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) iyo ALK (cellular IC50=20 nM), labaduba waa bartilmaameedyada muhiimka ah ee daaweynta kemotherabi kansarka.Markii Crizotinib lagu tijaabiyay xulashada xulashada iyo kinases kale waxaa la ogaaday inuu leeyahay enzyme IC50's gudaha 100-laab dhufashada c-MET ee 13 ee 120 kinases ee la tijaabiyay.Baaritaannada gacanta, Crizotinib waxaa la ogaaday inuu ka hortagayo RON (recepteur d'origine nantais) kinase leh 10-laab daaqad xulashada c-MET.Isku soo wada duuboo, wakiilkani wuxuu hor istaagaa koritaanka unugyada burooyinka.XALKORI®(Crizotinib) waa daawo dhakhtar qoray oo loo isticmaalo in lagu daweeyo dadka qaba kansarka sambabada unugyada aan yarayn (NSCLC) kaas oo ku faafay qaybaha kale ee jidhka waxaana sababa cilad ku timaada hiddasidaha loo yaqaan ALK (anaplastic lymphoma kinase) ama hidde-side loo yaqaan ROS1.Lama oga in XALKORI uu badbaado iyo waxtar u leeyahay carruurta.
