1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 daahirnimo ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee 1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) oo leh tayo sare leh, dhexdhexaad ah Crizotinib (CAS: 877399- 52-5).Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Dhexdhexaadiyeyaasha Crizotinib,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 1-Boc-4-(4-Bromopyrazol-1-yl) Piperidine |
| La mid ah | Crizotinib-D;tert-Butyl 4- (4-Bromopyrazol-1-yl) piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4- (4-Bromopyrazol-1-yl) piperidine;1- (4-Boc-Piperidino) -4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4- (4-Bromo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;1- (4-Boc-1-Piperidinyl) -4-Bromopyrazole;Xumaanta Crizotinib 4 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 877399-50-3 |
| Qaanuunka molecular | C13H20BrN3O2 |
| Miisaanka Molecular | 330.23 g/mol |
| Meesha dhalaalaysa | 77.0 ilaa 81.0 ℃ |
| Cufnaanta | 1.43 |
| Solubility | Ku milma Methanol |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Crizotinib (CAS: 877399-52-5) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Cad Adag | Cad Adag |
| Meesha dhalaalaysa | 77.0 ilaa 81.0 ℃ | U hogaansama |
| Biyaha waxaa qoray Karl Fischer | <0.50% | 0.11% |
| Daahirnimada / Habka Falanqaynta | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Mass | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
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Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Calaamadaha Khatarta Xn - Waxyeelo leh
Xeerarka Khatarta 22 - Waxyeelo leh haddii la liqo
1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) waxaa loo isticmaalaa sidii dhexdhexaad ah Crizotinib (CAS: 877399-52-5).Crizotinib (magaca ganacsiga Xalkori,) waa daawada kansarka ka hortagga ah ee u shaqeysa sida ALK (anaplastic lymphoma kinase) iyo ROS1 (c-ros oncogene 1) inhibitor, oo loo oggolaaday daawaynta qaar ka mid ah kansarka sambabada unugyada yaryar (NSCLC) ee Maraykanka iyo qaar ka mid ah wadamada kale, oo ay marayso tijaabooyin caafimaad oo lagu tijaabinayo badbaadada iyo waxtarkeeda anaplastic lymphoma unug weyn, neuroblastoma, iyo burooyinka kale ee adag ee horumarsan ee dadka waaweyn iyo carruurtaba.
Bishii Agoosto 2011, FDA waxay ogolaatay Crizotinib (PF-02341066) daawaynta anaplastic lymphoma kinase (ALK) dib u habeyn lagu sameeyay kansarka sambabada aan-unug-yarayn (NSCLC).Crizotinib waa dual ATP tartanka ka hortagga tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) iyo ALK (cellular IC50=20 nM), labaduba waa bartilmaameedyada muhiimka ah ee daaweynta kemotherabi kansarka.Markii Crizotinib lagu tijaabiyay xulashada xulashada iyo kinases kale waxaa la ogaaday inuu leeyahay enzyme IC50's gudaha 100-laab dhufashada c-MET ee 13 ee 120 kinases ee la tijaabiyay.Baaritaannada gacanta, Crizotinib waxaa la ogaaday inuu ka hortagayo RON (recepteur d'origine nantais) kinase leh 10-laab daaqad xulashada c-MET.
