1- (1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Purity ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) oo leh tayo sare leh, dhexdhexaad ah Crizotinib (CAS: 877399-52). -5).Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Dhexdhexaadiyeyaasha Crizotinib,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole |
| La mid ah | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl) piperidine;tert-Butyl 4- (4-Iodo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;tert-Butyl 4- (4-Iodopyrazolyl) piperidinecarboxylate;Xumaanta Crizotinib 16 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 877399-73-0 |
| Qaanuunka molecular | C13H20IN3O2 |
| Miisaanka Molecular | 377.22 g/mol |
| Meesha dhalaalaysa | 97℃ |
| Cufnaanta | 1.60±0.10 g/cm3 |
| Xasaasi ah | Iftiinka xasaasiga ah |
| Heerkulka Kaydinta | 2 ~ 8℃, Ka ilaali Iftiinka |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Crizotinib (CAS: 877399-52-5) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Cadaan ilaa iftiin jaale Adag | Cad Adag |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| ESI+ | waafaqsan | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.
Tusaalooyinka?Badeecadaha intooda badani waxay bixiyaan muunado bilaash ah oo loogu talagalay qiimeynta tayada, kharashka dhoofinta waa in ay bixiyaan macaamiisha.
Hantidhawrka Warshada?Hantidhawrka warshada soo dhawoow.Fadlan horay u sii ballan.
MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.
Gaadiidka?By Express (FedEx, DHL), hawada, badda.
Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) oo leh tayo sare, dhexdhexaad ah Crizotinib (CAS: 877399-52-5).Crizotinib waa daawaynta la beegsanayo ee kansarka sambabada unug yar oo ay samaysay Pfizer, USA.Waxaa loo ansixiyay suuqgeynta gudaha Mareykanka Agoosto 2011 waxaana lagu qoray tilmaamaha daawaynta kansarka sambabada caalamiga ah dhamaadka sanadka sida dawada safka kowaad ee bukaanada ALK-positive ah.La-ansixiyey Crizotinib waa habka ugu horreeya ee ogaanshaha hidda-socodka iyadoo la adeegsanayo fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, kani waa habka hadda loo isticmaalo tijaabooyinka caafimaad ee caalamiga ah si loo ogaado EML4-ALK hiddo-wadaha isku-dhafka ah ee NSCLC.Tijaabadani waxay kaa caawin doontaa in la ogaado bukaanada laga yaabo inay ka faa'iidaystaan daaweynta Crizotinib.on 25, tani waa daawadii ugu horeysay ee loo isticmaalo in lagu daweeyo bukaanada qaba deegaanka horumaray ama metastatic non-small cell kansarka sanbabada (NSCLC) in anaplastic lymphoma kinase (ALK) -positive sida ay go'aamisay SFDA-ansixiyey asay.
Crizotinib (PF-02341066) Crizotinib waa c-Met awood leh iyo ALK inhibitor, qiyamka IC50 ee baaritaanka unuggu waxay ahaayeen 11 nM iyo 24 nM, siday u kala horreeyaan.Sidoo kale waa horjooge awood leh oo ROS1 ah oo leh qiime Ki ka yar 0.025 nM.Crizotinib waxay u horseedi kartaa autophagy khadadka unugyada kansarka sanbabada ee kala duwan iyadoo la joojinayo dariiqa STAT3.
