CAS 945667-22-1 daahirnimo>99.0% (HPLC) API

Sharaxaad Gaaban:

CAS: 945667-22-1

Daahirsanaanta:>99.0% (HPLC)

Muuqaalka: Budada Cad

API, Tayo Sare, Wax Soo Saarka Ganacsiga

E-Mail: alvin@ruifuchem.com

Email noogu soo dir

Faahfaahinta Alaabta

Alaabooyinka La Xiriira

Tags Product

Sharaxaad:

Dhexdhexaadiyayaasha La Xiriira Bixinta Kiimikada Ruifu
CAS 361442-04-8
CAS 945667-22-1
(R)-1-Boc-3-Aminoperidine CAS 188111-79-7
(R)-(-)-3-Aminopperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Guryaha Kiimikada:

La mid ah	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0] ] hexane-3-Carbonitrile Hydrate
Lambarka CAS	945667-22-1
Lambarka CAT	RF-PI1992
Heerka Saamiyada	Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan
Qaanuunka molecular	C18H25N3O2·H2O
Miisaanka Molecular	333.43
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada Cad
aqoonsiga	A: IR B: Waqtiga Haynta HPLC
Daahirnimada / Habka Falanqaynta	> 99.0% (HPLC, Ku salaysan Qalalan)
Waxyaabaha Biyaha (KF)	5.3% ~ 7.3%
Hadhaaga dabka	<0.20%
Xumaanta Keliya	<0.50%
Wadarta wasakhda	<1.00%
Biraha culus	<10pm
Arsenic (As)	<2pm
Microbiology
Wadarta tirada saxanada	<1000cfu/g
Khamiirka & Caaryada	<100cfu/g
E. Coli	xun
S. Aureus	xun
Salmonella	xun
Nolosha shelf	24 bilood
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	API;Loo isticmaalo daawaynta Nooca II ee Sonkorowga

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka

Faa'iidooyinka:

FAQ:

Codsiga:

API (CAS: 945667-22-1) waa dipeptidyl peptidase-4 (DPP4) inhibitor ah oo la xushay lana beddeli karo oo laga yaabo in loo isticmaalo horumarinta daaweynta nooca 2aad ee sonkorowga.Waa xakameyn DPP4 oo la xushay oo la beddeli karo oo leh IC50 ee 26 nM iyo Ki ee 1.3 nM.IC50 qiimaha: 26 nM.Bartilmaameedka: DPP4 in vitro: Waxay leedahay xannibaad joogto ah oo Ki ah 1.3 nM oo loogu talagalay xannibaadda DPP4, taas oo 10-laab ka xoog badan Sitagliptin (laba kale oo DPP4 inhibitors ah) oo leh Ki of 13 iyo 18 nM.Intaa waxaa dheer, Waxay muujineysaa gaar ahaan DPP4 ka weyn midka DPP8 ama DPP9 enzymes (400-iyo 75- laab, siday u kala horreeyaan).Dheef-shiid kiimikaadkiisa ayaa laba-laab ka awood yar kan waalidka.Labadaba (CAS: 945667-22-1) iyo dheef-shiid kiimikaadkeedu aad bay u doorteen (> 4000-laab) ka hortagga DPP4 marka la barbar dhigo noocyo kala duwan oo borotiinno kale ah.(CAS: 945667-22-1) waxay yaraynaysaa hoos u dhaca hormoonka incretin ee glucagon-like peptide-1, taas oo kor u qaadeysa ficiladeeda, waxayna la xiriirtaa hagaajinta shaqada β-unugga iyo xakamaynta dheecaanka glucagon.in vivo: Aad bay waxtar u leedahay. marka la soo saaro hagaajinta qiyaasta qiyaasta ku-tiirsanaanta ee nadiifinta gulukooska ee qiyaasta qiyaasta 0.13-1.3 mg/kg ee jiirarka ob/ob marka loo eego kontaroolada.