Celecoxib CAS 169590-42-5 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Celecoxib (CAS: 169590-42-5) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Celecoxib,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Celecoxib |
| La mid ah | Celebrex;Dabaaldegga;Celecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4- [5- (4-Methylphenyl) -3- (Trifluoromethyl) -1H-Pyrazol-1-yl] benzenesulfonamide;5- (4-Methylphenyl) -1- (4-Sulfamoylphenyl) -3- (Trifluoromethyl) pyrazole |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 169590-42-5 |
| Qaanuunka molecular | C17H14F3N3O2S |
| Miisaanka Molecular | 381.37 g/mol |
| Meesha dhalaalaysa | 160.0 ilaa 165.0 ℃ |
| Cufnaanta | 1.43±0.10 g/cm3 |
| Biyuhu milmayn | Aan ku milmin Biyaha |
| Solubility | Aad ugu milmay Methanol;Ku milmay Ethanol |
| COA & MSDS | La heli karo |
| Tusaale | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Caddaan ama ku dhawaad cad budada crystalline | U hogaansama |
| Qiimayn | 98.0 ~ 102.0% | 99.8% |
| Meesha dhalaalaysa | 160.0 ilaa 165.0 ℃ | 162.2℃ |
| Biyaha waxaa qoray Karl Fischer | <0.50% | 0.11% |
| Hadhaaga dabka | <0.20% | 0.05% |
| Biraha culus (Pb) | ≤20pm | <10pm |
| Isku dhafka Celecoxib ee La Xiriira A | <0.40% | <0.20% |
| Celecoxib La Xiriira Isku-dhafka B | <0.10% | <0.10% |
| Xumaanta Shakhsiyeed Aan La Sheegin | <0.10% | <0.10% |
| Wadarta wasakhda | <0.50% | 0.20% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
Xidhmada:Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Celecoxib
C17H14F3N3O2S 381.4
4- [5- (4-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide;
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide [169590-42-5]
Qeexitaan
Celecoxib waxa uu ka kooban yahay NLT 98.0% iyo NMT 102.0% ee C17H14F3N3O2S, oo lagu xisaabiyey ku salaysan anhydrous
AQOONSIGA
• A. NUUugista INfrared <197>: [Xusuusin-Habab <197A>, <197K>, ama <197M> hoosta Nuugista Infrared waa la isticmaali karaa.]
[FIIRO GAAR AH-Haddii muuqalada la helay ay muujiyaan kala duwanaansho, milaan walaxda la baarayo iyo Heerka Tixraaca si gaar ah khamriga isopropyl, u bax engegan, oo qor spectra cusub.]
B. Wakhtiga haynta ee ugu sarraysa ee xal muunadu waxay u dhigantaa kan xalalka caadiga ah, sida lagu helay Assay.
ASSAY
HABKA
Badbaadinta: 2.7 g/L ee fosfooraska potassium monobasic oo lagu hagaajiyay phosphoric acid ilaa pH ah 3.0 ± 0.2
Marxaladda mobilada: Methanol, acetonitrile, iyo Buffer (3:1:6)
Biyo: Methanol iyo biyo (3:1)
Xalka ku habboonaanta nidaamka: 0.5 mg/ml ee USP
Celecoxib RS iyo 2.4 µg/ml mid kasta oo ka mid ah USP Celecoxib La Xiriira Isku-dhafka A RS iyo USP Celecoxib La Xiriira Isku-dhafka B RS ee Diluent
Xalka caadiga ah: 0.5 mg/mL ee USP Celecoxib RS ee dareeraha
Tusaalaha xalalka: 0.5 mg/mL ee Celecoxib ee dareeraha
Nidaamka Chromatographic
(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 215 nm
Tiirka: 4.6-mm × 25-cm;5-µm xirmo L11
Heerkulka tiirka: 60°
Heerka socodka: 1.5 ml/min
Cabbirka duritaanka: 25 µL
Waqtiga orodka: Qiyaastii 1.5 jeer heerka ugu sarreeya ee celecoxib
Ku habboonaanta nidaamka
Tusaalooyinka: Xalka ku habboonaanta nidaamka iyo xalalka caadiga ah
Shuruudaha ku habboonaanta
Xallinta: NLT 1.8 inta u dhaxaysa celecoxib laxiriira xayndaab A iyo Celecoxib iyo NLT 1.8 oo udhaxeysa Celecoxib iyo Celecoxib ee laxiriira xarunta B, Nidaamka ku haboonaanta
Qiyaasta heerka qaraabada: NMT 0.73%, Xalka caadiga ah
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolkiiba C17H14F3N3O2S ee qaybta Celecoxib ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × 100
rU = jawaabta ugu sarreysa ee xalka Tusaalaha
rS = jawaabta ugu sarreysa ee xalalka caadiga ah
CS = fiirsashada xalalka caadiga ah (mg/mL)
CU = fiirsashada saamiga saamiga (mg/mL)
Shuruudaha aqbalaadda: 98.0% ~ 102.0% ku salaysan anhydrous
XANUUNKA
wasakhda aan noolaha ahayn
• Biraha culus: NMT 20 ppm
Biyo: Acetone iyo biyo (17:3)
Xalka caadiga ah: Ku qas 1.0 mL ee Xalka Caadiga ah ee rasaasta, oo loo diyaariyey sida lagu faray biraha culus <231>, Reagents Gaar ah, oo leh Diluent ilaa 20 mL.
Xalka Tusaalaha: Ku mil 0.50 g oo Celecoxib ah 20mL oo ah Diluent.
Xalka maran: 20 ml oo ah Diluent
Falanqaynta
Tusaalooyinka: Xalka caadiga ah, xal madhan, iyo xal muunad
Xalka kasta, ku dar 2 mL oo pH 3.5 Acetate Buffer ah oo loo diyaariyey sida lagu faray Heavy Metals <231>, Habka I. Isku qas, oo ku dar xal kasta 1.2 mL of thioacetamide-glycerin saldhigga TS.Isla markiiba isku qas, oo u oggolow inaad istaagto 2 daqiiqo.U gudub xalalka shaandheynta cabbirka daloolka 0.45-µm.Is barbar dhig dhibcaha miirayaasha laga helay mid kasta oo ka mid ah xalalka.
Shuruudaha aqbalaadda: Midabka madaw ee bunni-madaw ee goobta ka dhashay xal muunad kama badna kan meesha ka imanaysa xalalka caadiga ah.Tijaabadu waa mid aan shaqaynayn haddii xalka caadiga ahi aanu muujin midab madow-brown marka la barbar dhigo xalka maran.
• Hadhaaga dabka <281>: NMT 0.2%, iyadoo la isticmaalayo crucible platinum
Waxyeellada dabiiciga ah
Hab-socodka
Buffer, Marxaladda Mobilka, Diluent, Xalka ku habboonaanta Nidaamka, Xalka Tusaalaha, iyo Nidaamka Chromatographic: U wad sida lagu faray Assay.
Xalka caadiga ah: 0.5 µg/ml ee USP Celecoxib RS ee dareeraha
Ku habboonaanta nidaamka
Tusaalooyinka: Xalka ku habboonaanta nidaamka iyo xalalka caadiga ah
Shuruudaha ku habboonaanta
Qaraarka: NLT 1.8 inta u dhaxaysa Celecoxib A iyo Celecoxib iyo NLT 1.8 inta u dhaxaysa Celecoxib iyo Celecoxib ee la xidhiidha xarunta B, Nidaamka ku habboonaanta
Saamiga calaamad-ilaa-sanqa: NLT 20, Xalka caadiga ah
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolkiiba wasakh kasta ee qaybta Celecoxib ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × 100
rU = jawaabta ugu sarreysa ee wasakh kasta oo ku jirta xalka Tusaalaha
rS = jawaabta ugu sarreysa ee celecoxib ee xalka caadiga ah
CS = fiirsashada celecoxib ee xalka caadiga ah (mg/mL)
CU = fiirsashada Celecoxib ee xalka muunada (mg/mL)
Shuruudaha aqbalaadda
Nijaasta shakhsi ahaaneed: eeg Shaxda 1.
[FIIRO GAAR AH- iska daa wax kasta oo wasakhaysan oo ka yar 0.05%.]
Shaxda 1
| Magaca | Waqtiga Haynta Qaraabo | Shuruudaha Ogolaanshaha NMT (%) |
| Celecoxib laxiriira iskudarka Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | - |
| Isku dhafka Celecoxib ee la xiriira Bb | 1.1 | 0.10 |
| Nijaasnimo shakhsi ah oo aan la cayimin | - | 0.10 |
| Wadarta wasakhda | - | 0.5 |
a 4- [5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
b 4- [3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
IMTIXAANO GAAR AH
• GO'aaminta biyaha, Habka I <921>: NMT 0.5%, iyadoo la isticmaalayo muunad 400-mg
SHURUUD DHEERAAD AH
Baakadaha iyo Kaydinta: Ku kaydi weel cidhiidhi ah, oo ka ilaalinaya iftiinka iyo qoyaanka.Ku kaydi heerkulka qolka
• HEERARKA Tixraaca USP <11>
USP Celecoxib RS
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide
C17H14F3N3O2S 381.4
Isku dhafka USP Celecoxib La Xiriira A RS
4-[5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
Isku dhafka USP Celecoxib La Xiriira B RS
4-[3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
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| Calaamadaha halista | Xn - Waxyeelo |
| Xeerarka Khatarta | R20/21/22 - Waxyeelo xagga neefsashada, taabashada maqaarka iyo haddii la liqo. |
| R52 - Waxyeelo u leh noolaha biyaha | |
| R61 - Waxa laga yaabaa inay waxyeelo u geysato ilmaha uurka ku jira | |
| R60 - Waxa ay wiiqi kartaa dhalmada | |
| Sharaxaada Badbaadada | S22 - Ha neefsan boorka. |
| S24/25 - Iska ilaali taabashada maqaarka iyo indhaha. | |
| S28 - Kadib taabashada maqaarka, isla markiiba ku dhaq saabuun-suds badan. | |
| S37/39 - Xidho galoofyada ku haboon iyo ilaalinta indhaha/wejiga | |
| Aqoonsiga UN-ka | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | DB2944937 |
| Koodhka HS | 2935900090 |
| Heerka khatarta | XANUUNSAN |
Celecoxib iyo Rofecoxib waa laba COX-2 inhibitors oo hadda la isticmaalo.Si guul leh u horumariyay GD Searle & Pfizer Co. (US,) oo la sii daayay 1999, magaca ganacsiga: Celebrex.Celecoxib waa wakiilka nonsteroidal, anti-bararka leh xanuunka xanuunka iyo saamaynta bararka, taasoo keenta dhacdooyinka ugu hooseeya ee boogaha sare ee mareenka caloosha iyo mindhicirka iyo dhibaatooyinka kale.Loo isticmaalo kiliinikada si loogu daweeyo osteoarthritis ba'an iyo dabadheeraad ah iyo rheumatoid arthritis-ka, oo leh door xanuunka xanuunka ka-hortagga caabuqa, yaraynta calaamadaha iyo calaamadaha osteoarthritis iyo rheumatoid arthritis-ka.
Celecoxib (CAS: 169590-42-5), loogu talagalay gargaarka iyo maaraynta osteoarthritis (OA), rheumatoid arthritis (RA), rheumatoid arthritis-ka carruurta (JRA), spondylitis ankylosing, xanuunka degdega ah, dysmenorrhea aasaasiga ah iyo afka laga qaato daryeelka caadiga ah ee bukaanka. oo leh adenomatous polyposis qoyska.
Celecoxib (CAS: 169590-42-5) waxay leedahay saamaynta anti-bararka iyo xanuunka xanuunka ee NSAIDs.Sababtoo ah qaab-dhismeedka kiimikada, waxaa lagu dari karaa COX-2, si door ah u xakameynaya COX-2.Kooxdeeda phenyl waxay ku xidhan tahay kanaalka hydrophobic ee COX-2, iyo sulfonamide hydrophilic waxay samaysaa silsilad hydrogen ah oo leh 513 arginine iyo 90 histidine ee COX-2 "jeebka dhinaca."Waxay kaloo xiriir dhow la leedahay arginine booska COX-2120 waxayna door ka ciyaartaa ka hortagga COX-2 inay u beddesho arachidonic acid una beddelo prostaglandins kuwaas oo waxyeello u leh jidhka bini'aadamka. -2, Celecoxib ma geli karto COX-1 molecule, mana joojin karto isbeddelka arachidonic acid ee prostaglandins.Sidaas darteed, waxay leedahay saameyn wanaagsan oo ka hortagga bararka iyo xanuunka, waxay ilaalisaa xabka caloosha, waxay ilaalisaa socodka dhiigga kelyaha, waxay xakameysaa isu-ururinta platelet, waxayna xallisaa Dhibaatooyinka cuncunka caloosha ee NSAID-yada sida caadiga ah loo isticmaalo.
Celecoxib (CAS: 169590-42-5) waxaa loogu talagalay daawaynta osteoarthritis iyo rheumatoid arthritis-ka.Isticmaalkeeda waa ka mamnuuc shakhsiyaadka leh xasaasiyadda sulfonamides ama NSAIDs kale.Waa in si taxadar leh loo isticmaalo dadka qaba cudurka beerka.Isdhexgalku wuxuu ku dhacaa daawooyinka kale ee keena CYP2C9 (tusaale rifampin rifampin) ama u tartamaya dheef-shiid kiimikaadka enzyme-kan (tusaale fluconazole, leflunomide).Dareen-celinta xun ee ugu badan ee celecoxib waa mid fudud ama dhexdhexaad ah saamaynta GI sida dyspepsia, shuban, iyo calool xanuun.GI-da halista ah iyo saamaynta kelyaha ayaa u dhacay si dhif ah.
