Chloramphenicol CAS 56-75-7 Nadiifinta ≥99.0% (HPLC) Nadiif Sare
Soo saaraha soo saaraha oo leh nadiif sare iyo wax soo saar ganacsi
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
| Magaca Kiimikada | Chloramphenicol |
| La mid ah | D-(-)-threo-2-Dichloroacetamido-1- (4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R) -1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
| Lambarka CAS | 56-75-7 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C11H12Cl2N2O5 |
| Miisaanka Molecular | 323.13 |
| Meesha dhalaalaysa | 149.0 ilaa 153.0 ℃ ( shidan) |
| Xasaasi ah | Iftiinka xasaasiga ah |
| Solubility | Aad ayuu ugu milmay Ethanol, Methanol, Acetone.Ku milmay Ether, Chloroform.Aan lagu milmi karin BenzeneDhaqan ahaan Aan Biyo Ku milmin |
| Xaalada Maraakiibta | Lagu soo raray Heer kulka jawiga |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ilaa qafiif ah budada jaalaha ah |
| Aqoonsiga A | Nuugista Infrared |
| Aqoonsiga B | Waqtiga haynta ee ugu sarreysa chromatogram-ka diyaarinta Assay waxay u dhigantaa tan ku jirta chromatogram-ka diyaarinta Heerka, sida laga helay Assay. |
| Wareegga indhaha ee gaarka ah | +17.0°~+20.0° |
| Meesha dhalaalaysa | 149.0 ~ 153.0 ℃ |
| Crystallinity | Buuxiyay Shuruudaha |
| pH | 4.5 ~ 7.5 |
| Xumaanta Keliya | ≤0.50% |
| Wadarta wasakhda | ≤1.00% |
| Biraha culus | ≤20pm |
| Arsenic | ≤1ppm |
| Khasaare xagga qalajinta | ≤0.50% (105 ℃, 3 saacadood) |
| Hadhaaga dabka | ≤0.10% |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) |
| Heerka Imtixaanka | Heerka Ganacsiga;JP;USP |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg/Drum, ama sida waafaqsan shuruudaha macaamiisha.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol wuxuu ka kooban yahay wax aan ka yarayn 97.0 boqolkiiba kana badnayn 103.0 boqolkiiba C11H12Cl2N2O5.
Baakadaha iyo kaydinta-Ku xafid weel cidhiidhi ah.
Calaamadeynta-Halka loogu talagalay in loogu isticmaalo diyaarinta foomamka qiyaasta la isku duro ama kuwa kale ee nadiifka ah, calaamaddu waxay sheegaysaa inay madhalays tahay ama ay tahay in la marsiiyo habayn dheeraad ah inta lagu jiro diyaarinta foomamka qiyaasta qiyaasta la isku duro ama kale
Heerarka Tixraaca USP <11>-
USP Chloramphenicol RS Guji si aad u aragto Qaabdhismeedka
USP Endotoxin RS
Aqoonsiga -
J: Nuugista Infrared <197K>.
B: Waqtiga haynta ee ugu sarreysa chromatogram-ka diyaarinta Assay waxay u dhigantaa tan ku jirta chromatogram-ka diyaarinta Heerka, sida laga helay Assay.
Kala duwanaanta dhalaalaysa <741>: inta u dhaxaysa 149 iyo 153.
Wareeg gaar ah <781S>: inta u dhaxaysa +17.0 iyo +20.0.
Xalka tijaabada: 50 mg, aan la qalajin, halkii ml, ee khamriga fuuqbaxay.
Crystallinity <695>: buuxiyey shuruudaha.
Bakteeriyada endotoxins 85-Halka Chloramphenicol loogu talagalay in loogu isticmaalo diyaarinta foomamka qiyaasta qiyaasta la isku duro, waxay ka kooban tahay wax aan ka badnayn 0.2 USP Endotoxin Unit halkii mg ee chloramphenicol.
Dhalmo-dhalaysnimada 71- Meesha calaamaddu ku sheegayso in Chloramphenicol ay tahay madhalays, waxay buuxinaysaa shuruudaha marka la tijaabiyo sida lagu faray sifaynta Membrane ee hoos timaada Tijaabada Madhalaysnimada Alaabta in la baaro, marka laga reebo isticmaalka 1 g oo muunado adag ah.
pH <791>: inta u dhaxaysa 4.5 iyo 7.5, ee joojinta aqueous ka kooban 25 mg halkii ml.
Nadiifinta Chromatographic-Ku milmaan qaddar sax ah oo Chloramphenicol ah oo ku jira methanol si loo helo xal tijaabo ah oo ka kooban 10 mg halkii ml.U diyaari xal USP Chloramphenicol RS ee methanol ka kooban 10 mg halkii mL (xalka caadiga ah A).Ku qas qaybo ka mid ah xalalka caadiga ah A tiro ahaan methanol si aad u hesho Heerarka Xalka B oo ka kooban 100 µg halkii ml iyo Xalka caadiga ah C oo ka kooban 50 µg halkii ml.Codso qaybo 20-µL oo kala duwan oo ah xalka tijaabada iyo xalalka caadiga ah ee B iyo C si saxan koromografi ah oo khafiif ah oo ku habboon (fiiri Chromatography 621), oo lagu dahaadhay lakabka 0.25-mm ee isku dhafka silica chromatographic.Ku samee chromatogram-ka qaab dareere ah oo ka kooban isku-dar ah chloroform, methanol, iyo glacial acetic acid (79:14:7) ilaa uu dareeraha hore u dhaqaaqo qiyaastii saddex meelood meel saddex meelood oo dhererka saxanka.Saxanka ka soo saar qolka, hawo- engegan, oo ka baadh iftiinka UV-mawjadaha gaaban hoostiisa: meel kasta oo aan ahayn meesha ugu muhiimsan ee laga helay xalka tijaabada kama badna cabbirka ama xoojinta barta ugu muhiimsan ee laga helay xalalka heerka B (1% ), iyo wadarta wasakhda ah ee ay matalaan dhammaan dhibco aan ahayn meesha ugu muhiimsan, iyada oo lagu saleynayo isbarbardhigga dhibcaha dhibcahaas oo leh xoojinta dhibcaha ugu muhiimsan ee laga helay xalalka Standard B iyo C, kama badna 2% .
Imtixaan-
Marxaladda wareegta- Diyaari isku dhafka habboon ee biyaha, methanol, iyo glacial acetic acid (55:45:0.1).Samee hagaajin haddii loo baahdo (eeg Habboonaanta Nidaamka ee hoos timaada Chromatography 621).
Diyaargarowga caadiga ah- Kala mii tirada saxda ah ee USP Chloramphenicol RS ee wajiga mobaylka, oo u milo tiro ahaan, iyo si tartiib tartiib ah haddii loo baahdo, iyada oo wejiga Mobile-ka si aad u hesho xal la og yahay oo ku saabsan 80 µg halkii ml.Ku sifee qayb ka mid ah xalkan 0.5-µm ama filter porosity filter, oo isticmaal shaandhaynta cad sida diyaarinta caadiga ah.
Diyaarinta Assay- Ku wareeji qiyaastii 200 mg ee Chloramphenicol, si sax ah loo miisaamay, ilaa 100-mL weel mug leh, ku dar wajiga mobilada mugga, oo qas.Ku wareeji 4.0 mL oo ah xalka ka dhashay dhalada mugga 100-mL, ku milo wejiga Mobile ilaa mugga, oo qas.Ku sifee qayb ka mid ah xalkan 0.5-µm ama filter porosity filter, oo isticmaal shaandhaynta cad sida diyaarinta Assay.
Nadaamka Chromatographic (eeg Chromatography <621>)-Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay 280-nm baaraha iyo tiir 4.6-mm × 10-cm ah oo ka kooban 5-µm xirmo L1.Heerka socodka waa qiyaastii 1 mL daqiiqadii.Chromatograph the Standard-diyaarinta, oo qor jawaabaha ugu sarreeya sida lagu faray habraaca: waxtarka tiirka ee laga go'aamiyay ugu sarreeya falanqaynta kama yarayn 1800 taarikada aragtida, qodobka dabada kama badna 2.0, iyo jaangooyada heerka qaraabo ee cirbadaha soo noqnoqda ma aha in ka badan 1.0%.
Habka-[xusuuso-Isticmaal meelaha ugu sarreeya halka jawaabaha ugu sarreeya lagu muujiyo.] Si gooni ah u duri mugga siman (qiyaastii 10 µL) ee diyaarinta Heerka iyo diyaarinta Assay chromatograph-ka, duub chromatogram-yada, oo cabbir jawaabaha meelaha ugu sarreeya.Xisaabi tirada, mg, ee C11H12Cl2N2O5 ee qaybta Chloramphenicol ee ay qaadatay qaacidada:
2.5C (rU / rS)
taas oo C ay tahay fiirsashada, µg halkii ml, ee USP Chloramphenicol RS ee diyaarinta Heerka, iyo rU iyo rS ay yihiin jawaabaha ugu sarreeya ee laga helay diyaarinta Assay iyo diyaarinta Heerka, siday u kala horreeyaan.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R) -1,3-dihydroxy-1- (4-nitrophenyl) propan-2-yl]acetamide [56-75-7]
Chloramphenicol waxay ka kooban tahay wax aan ka yarayn 980 mg (awood) iyo in aan ka badnayn 1020 mg (awood) mgkiiba, oo lagu xisaabiyo sal qallalan.Awoodda Chloramphenicol waxaa lagu muujiyay cuf (awood) chloramphenicol (C11H12Cl2N2O5).
Sharaxaada Chloramphenicol waxay u dhacdaa sida cadaan ilaa huruud ah, crystals ama budada crystalline.
Waxay si xor ah ugu milmi kartaa methanol iyo ethanol (99.5), oo wax yar bay ku milmi kartaa biyaha.
Aqoonsiga (1) Go'aami nuugista spectrum ee muunadda muunada ee lagu helay Assay sida lagu hagayo Ultraviolet-visible Spectrophotometry <2.24>, oo barbar dhig spectrum iyo tixraaca Spectrum ama spectrum ee xalka Chloramphenicol RS oo loo diyaariyey si la mid ah sidii Xalka muunada: labada spectra waxay soo bandhigaan xoojinta nuugista isku midka ah ee dhererka hirarka isku midka ah.
(2) Go'aami nooca nuugista infrared-ka ee Chloramphenicol sida lagu faray habka potassium bromide disk ee hoos yimaada Infrared Spectrophotometry <2.25>, oo barbar dhig spectrum Spectrum Tixraaca ama spectrum of Chloramphenicol RS: labada spectra waxay muujinayaan xoojinta nuugista isku mid ah tirooyinka hirarka.
Wareegga indhaha <2.49> [a] 20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 ml, 100 mm.
Barta dhalaalka <2.60> 150 ~ 155 ℃
Daahirnimada (1) Biraha culus <1.07>- Ku wad 1.0 g oo Chloramphenicol ah sida uu qabo Habka 2, oo samee tijaabada.Ku diyaari xalka xakamaynta 2.5 mL ee Xalka Lead Heerka (aan ka badnayn 25 ppm).
(2) Arsenic <1.11>-Ku diyaari xalka tijaabada 2.0 g of Chloramphenicol sida ku cad Habka 4, oo samee tijaabada (aan ka badnayn 1 ppm).
(3) Walxaha la xidhiidha-Ku mil 0.10 g oo Chloramphenicol ah 10 ml oo methanol ah, oo u isticmaal xalkan sidii xal muunadda.Beet 1 ml oo muunada muunada ah, ku dar methanol si aad u samayso 100 ml oo sax ah, una isticmaal xalinta xalinta caadiga ah (1).Beet 10 ml oo ah xalalka caadiga ah (1), ku dar methanol si aad u samayso 20 ml oo sax ah, una isticmaal xalkan sida xalalka caadiga ah (2).Ku samee tijaabada xalalkan sida lagu faray Chromatography-ka khafiifka ah <2.03>.Bar 20 mL mid kasta oo ka mid ah xalalka muunada iyo xalalka caadiga ah (1) iyo (2) saxan silica gel ah oo leh tilmaame fluorescent ah oo loogu talagalay chromatography khafiif ah, samee saxanka isku dar ah chloroform, methanol iyo acetic acid (100) 79:14:7) ilaa masaafo qiyaastii ah 15 cm, oo hawo qalaji saxanka.Ku baadh iftiinka ultraviolet (mawjada ugu weyn: 254 nm): dhibco kale oo aan ahayn meesha ugu muhiimsan iyo barta asalka ah ee laga helay xalka muunada kama badna meesha laga helay xalka caadiga ah (1), iyo wadarta guud ee maadada Dhibcahaan ka soo baxa muunada muunada kama badna 2.0%.
Luminta qallajinta <2.41> In aan ka badnayn 0.5% (1 g, 105 ℃, 3 saacadood).
Hadhaaga dabka <2.44> In aan ka badnayn 0.1% (1 g).
Assay Si sax ah u miisaam qaddarka Chloramphenicol iyo Chloramphenicol RS, oo u dhiganta 0.1 g (awood), milaan midkiiba 20 ml oo methanol ah, oo ku dar biyo si aad u samayso 100 ml.Tuub 20 ml mid kasta oo ka mid ah xalalkan, ku dar biyo si aad u samayso 100 ml oo sax ah.Dhuumaha 10 mL mid kasta oo ka mid ah xalalkan, ku dar biyo si aad u samayso 100 ml oo sax ah, oo u isticmaal xalalkan sida xalka muunada iyo xalalka caadiga ah.Go'aanso nuugista, AT iyo AS, at 278 nm ee xalka muunada iyo xalka caadiga ah sida lagu faray ultraviolet-muuqaalka Spectrophotometry <2.24>.
Qadarka [mg (awood)] chloramphenicol (C11H12Cl2N2O5)
＝ MS × AT/AS × 1000
MS: Qadarka [mg (awood)] ee Chloramphenicol RS
qaaday
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R11 - Aad u guban kara
R39/23/24/25 -
R23/24/25 - Sunta neefsashada, taabashada maqaarka iyo haddii la liqo.
Sharaxaada Badbaadada S53 - Iska ilaali soo-gaadhista - hel tilmaamo gaar ah kahor isticmaalka.
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Aqoonsiga Qaramada Midoobay 2811
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RTECS AB6825000
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HS code 2941400000
Khatarta Heerka 3
Sunta LD50 afka ee jiirka: 2500mg/kg
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P270: Ha cunin, ha cabbin, ha cabbin sigaar markaad isticmaalayso alaabtan.
P202: Ha qaban ilaa dhammaan taxaddarrada badbaadada la akhriyo lana fahmo.
P201: Hel tilmaamo gaar ah ka hor isticmaalka.
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Shanghai Ruifu Chemical Co., Ltd. waa alaab-qeybiyaha ugu horreeya ee Chloramphenicol (CAS: 56-75-7) oo leh tayo sare.Chloramphenicol waa antibiyootig ballaran oo liddi ku ah bakteeriyada, taas oo ah doorashada koowaad ee daawaynta tiifowga iyo paratyphoid, marka labaad, waxaa loo isticmaalaa daawaynta cuduro kala duwan oo faafa oo ay sababaan microorganisms xasaasi ah.Dareen-celinta xun ee halista ah awgeed ayaa hadda loo isticmaalaa si ka yar iyo ka yar.Bakteeriyada spectrum, shaqada iyo isticmaalku waxay la mid yihiin chloramphenicol ee daawaynta Salmonella Typhi, Shigella, Escherichia coli, hargabka, Brucella, caabuqyada oof wareenka oo ay keento cocci iyo antibiyootiga kale ee ka hortagga caabuqa.Chloramphenicol waxaa inta badan loo isticmaalaa in lagu daaweeyo caabuqa kaadi mareenka, oof wareenka, caabuqa caloosha iyo septicaemia ee ay keento bakteeriyada xasaasiga ah, iyo sidoo kale dhibcaha indhaha dibadda iyo dhibcaha dhegta.
UN3249 Daawo, adag, sun, nos, Heerka khatarta: 6.1;Calaamadaha: 6.1-Waxyaabaha sunta ah.UN2811 sunta adag, organic, nos, Heerka khatarta: 6.1;Calaamadaha: 6.1- Qalabka sunta ah, Magaca Farsamada ayaa loo baahan yahay.
