D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Warshada Tayada Sare
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee D- (+) - Cycloserine (CAS: 68-41-7) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, tiro yar iyo tiro badan oo la heli karo.Iibka D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | D-(+)-Cycloserine |
| La mid ah | D-Cycloserine;(+)-Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Heerka Saamiyada | In Stock |
| Lambarka CAS | 68-41-7 |
| Qaanuunka molecular | C3H6N2O2 |
| Miisaanka Molecular | 102.09 g/mol |
| Meesha dhalaalaysa | 137℃ |
| Xasaasi ah | Xasaasiyadda hawada, Xasaasida kulaylka |
| Solubility | Ku milmay Biyaha.Waxoogaa Ku milmay Methanol iyo Propylene Glycol.Aan ku milmin Chloroform iyo Eter. |
| Heerkulka Kaydinta | Meel Qabow & Qallalan (2 ~ 8 ℃) |
| COA & MSDS | La heli karo |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Budada Crystalline ee Cadaan ama Bacaad ah | U hogaansama |
| Wareeg gaar ah [α]20/D | +108.0° ilaa +114.0° (C=5, 2N NaOH) | +111.9° |
| Aqoonsiga | Midabka Buluuga ah si tartiib tartiib ah loo horumariyay | Midabka buluuga ah |
| Alaabta Uumiga | ≤0.80% (oo ah 286nm) | 0.08% |
| Khasaare xagga qalajinta | <1.00% | 0.38% |
| Hadhaaga dabka | <0.50% | 0.10% |
| Biraha culus (Pb) | ≤10pm | <10pm |
| wasakhda kacsan | ||
| - Methanol | ≤500pm | <500pm |
| - Acetone | ≤500pm | <500pm |
| Baadhitaanno (Antibiyootiko-Baadhitaannada Microbial) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 ilaa 6.5 | 5.98 |
| FTIR | waafaqsan | waafaqsan |
| IR Spectrum | waafaqsan | waafaqsan |
| NMR Spectrum | waafaqsan | waafaqsan |
| Gabagabo | Alaabtan marka la kormeero waxay waafaqsan tahay heerka USP-35 | |
Cycloserine [68-41-7].
Cycloserine waxay leedahay awood aan ka yarayn 900µg ee C3H6N2O2 mgkiiba.
Baakadaha iyo kaydinta-Ku xafid weel cidhiidhi ah.
Heerarka Tixraaca USP <11>-
USP Cycloserine RS
Aqoonsiga-Ku milmi qiyaastii 1 mg 10 mL ee 0.1 N sodium hydroxide.Si 1 mL ee xalka natiijada ku dar 3 mL oo ah 1 N acetic acid iyo 1 mL oo isku dar ah, la diyaariyey 1 saac ka hor isticmaalka, qaybo siman oo ah sodium nitroprusside (1 in 25) iyo 4 N sodium hydroxide: midab buluug ah si tartiib tartiib ah horumarisa.
Alaabooyinka uumiga- nuugista (eeg Spectrophotometry iyo Iftiin-kala-firdhinta <851>) ee 285 nm, oo lagu go'aamiyay 0.1 N sodium hydroxide xal ka kooban 0.40 mg halkii mL kama badna 0.80.
Wareeg gaar ah <781S>: inta u dhaxaysa 108° iyo 114°.Xalka tijaabada: 50 mg halkii ml, 2 N sodium hydroxide.
Crystallinity <695>: buuxiyey shuruudaha
pH <791>: inta u dhaxaysa 5.5 iyo 6.5, ee xal (1 in 10).
Luminta qalajinta <731>-Ku qallaji qiyaastii 100 mg dhalada capillar y-joojinta ee faakuumka 60℃ 3 saacadood: waxay luminaysaa wax aan ka badnayn 1.0% miisaankeeda.
Hadhaaga dabka <281>: in aan ka badnayn 0.5%, hadhaaga gubtay waxaa lagu qoyay 2 mL oo nitric acid iyo 5 dhibcood oo sulfuric acid ah.
Imtixaan-
pH 6.8 Fosfate buffer-U diyaari sida lagu faray Xalalka Buffer ee hoos yimaada Xalka qaybta Reagents, Tilmaamayaasha, iyo Xalka.
Marxaladda wareegta-Ku mil 0.5 g oo sodium 1-decanesulfonate ah 800 ml oo biyo ah, ku dar 50 mL oo acetonitrile ah iyo 5 mL oo ah glacial acetic acid, iskuna qas.Ku hagaaji 1 N sodium hydroxide una beddel pH ah 4.4.Shaandhee, iyo degas.Samee hagaajin haddii loo baahdo y (eeg Habboonaanta Nidaamka ee hoos timaada Chromatography <621>).
Diyaarinta caadiga ah-Tirada si sax ah u milmaan tirada USP Cycloserine RS ee pH 6.8 Fosfate kaydinta si aad u hesho xal la og yahay oo ku saabsan 0.4 mg halkii ml.
Diyaarinta Assay-Ku wareeji qiyaastii 20 mg oo Cycloserine ah, oo si sax ah loo miisaamay, ilaa 50-mL weel mug leh, ku milmi oo ku mili pH 6.8 Fosfate kaydka mugga, oo qas.
Nadaamka Chromatographic (eeg Chromatography <621>)-Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay 219-nm qalabka wax baadha iyo tiir 4.6-mm × 25-cm ah oo ka kooban 5-µm xirmo L1.Heerka socodka waa qiyaastii 1 mL daqiiqadii.Heerkulka tiirka waxaa lagu hayaa qiyaastii 30°.Chromatograph ee heerka diyaarinta, oo qor jawaabaha ugu sarreeya sida lagu faray Habka: qodobka dabada kama badna 1.8;iyo weecasho heerka qaraabo ah ee cirbadaha soo noqnoqda kama badna 2.0%.
Habka-Si gooni ah u duri mugga siman (qiyaastii 10 µL) ee diyaarinta Heerka iyo diyaarinta Assay chromatograph-ka, duub chromatogram-yada, oo cabbir jawaabaha ugu sarreeya ee cycloserine.Ku xisaabi tirada, µg, ee C3H6N2O2 mg kasta oo Cycloserine ah oo ay qaadato qaacidada:
50,000(C/W)(rU/rS)
taas oo C ay tahay xoojinta, mg per mL, ee USP Cycloserine RS ee diyaarinta Standard;W waa tirada, mg, ee Cycloserine ee la qaatay si loogu diyaariyo diyaarinta Assay;iyo rU iyo rS waa jawaabaha ugu sarreeya ee cycloserine ee laga helay diyaarinta Assay iyo diyaarinta Heerka, siday u kala horreeyaan.
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xidhan meel qabow oo engegan (2 ~ 8℃) bakhaar ka fog walxaha aan ku haboonayn.Ka ilaali iftiinka iyo qoyaanka.
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MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
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D- (+) - Cycloserine (CAS: 68-41-7) waxay leedahay dabeecad hygroscopic xoog leh, waxay ku milmi kartaa biyaha, wax yar bay ku milmi kartaa aalkolada hoose, acetone iyo dioxane, oo si dhib leh ugu milmay chloroform iyo ether petroleum.Waxay ku xasilloon tahay xalalka alkaline-ka waxayna si degdeg ah u jajabisaa xalal acidic ama dhexdhexaad ah.Sida antibiyootiko ballaadhan, cycloserine waxay ka hortagtaa bakteeriyada Gram-positive iyo Gram-negative, rickettsia iyo qaar ka mid ah protozoa, marka laga reebo qaaxada Mycobacterium. Vinactane para-aminosalicylic acid, isoniazid iyo pyrazinamide.Cycloserine wax yar ayey la midowdaa isoniazid ee ka hortagga qaaxada Mycobacterium H37RV, laakiin kama midho dhaliso mana ka soo horjeedo streptomycin.Alaabtu waa wakiilka bakteeriyada, sidaas darteed ma samayn doonto saameyn bakteeriyada xitaa marka la kordhinayo qiyaasta ama la dheereynayo wakhtiga ficilka ee bakteeriyada.
Farsamaynta ficilka bakteeriyada D-cycloserine waa in la joojiyo biosynthesis ee peptidoglycan ee derbiga unugyada.Maaddaama ay tahay analoogga qaabdhismeedka D-alanine, D-cycloserine waxay si tartan ah u joojin kartaa dhaqdhaqaaqa alanine racemase iyo D-alanyl-D-alanine synthetase, kuwaas oo ah laba enzymes oo muhiim ah oo ku jira isku-dhafka peptidoglycan.D-cycloserine waxay muujinaysaa dhaqdhaqaaq daciif ah oo ka hortag ah oo ka dhan ah qaaxada Mycobacterium taas oo ah 1/10 ilaa 1/20 oo kaliya ee streptomycin.Faa'iidada alaabtu waa in ay waxtar u leedahay noocyada qaaxada ee Mycobacterium u adkaysta oo ay u dhowdahay in ay keento iska caabbinta daawada.Alaabta waxa loo isticmaali karaa dawooyinka kale ee ka hortagga qaaxada ee daawaynta qaaxada ee ay keento qaaxada Mycobacterium u adkaysata.
Cycloserine waa dawada ka hortagga qaaxada ee safka labaad.Waxay joojin kartaa koritaanka qaaxada Mycobacterium, laakiin saameyntu aad bay uga liidataa marka loo eego daawooyinka safka hore.Waxtarka ay ku leedahay daawaynta tiibishada waa mid aad u hooseysa.Isticmaalka dawada kaligaa waxay soo saari kartaa caabbinta daawada, laakiin iska caabintu waxay u dhacdaa si tartiib ah marka la barbar dhigo daawooyinka kale ee ka hortagga tiibishada.Ma jiraan wax iska caabin ah oo u dhexeeya cycloserine iyo daawooyinka kale ee ka hortagga tiibishada.Habka ficilka bakteeriyada bakteeriyada ayaa ah in la joojiyo isku dhafka peptidoglycan ee gidaarka unugyada bakteeriyada, taasoo keenta cillad xagga dhismaha gidaarka unugyada.Qaybta ugu muhiimsan ee dhismaha gidaarka unugyada bakteeriyada waa peptidoglycan, kaas oo ka kooban N-acetylglucosamine (GNAc) iyo N-acetylmuramic acid (MNAc).N-acetylmuramic acid waxay ku xidhan tahay pentapeptide waxayna ku xidhaa N-acetylglucosamine qaab la soo koobay oo ka duwan.Sameynta cytoplasmic peptidoglycan precursor waxaa laga yaabaa inay carqaladeyso cycloserine, maadaama kan dambe uu xannibi karo jinsiyada iyo synthetase ee D-Alanine, oo sidaas darteed xannibaya samaynta N-acetylmuramic acid.
D-Cycloserine waxaa lagu heli karaa iyada oo loo marayo farsamada halsano ama iyada oo loo marayo synthesis toos ah.Bakteeriyada loo isticmaalo halsano waa Actinomyces laven-dulae.Dhexdhexaadinta halsano waxay ka kooban tahay dextrin, dextrose, istaarij, budada soybean, budada khamiirka, ammonium sulfate, ammonium nitrate, calcium carbonate, chloride sodium, magnesium sulfate iyo saliid soybean ah.Habka isku-dhafka ah, D-Cycloserine waxaa laga helay β-Aminooxy alanine ethyl ester hydrochloride by falcelinta potassium hydroxide ee falcelinta wareegga wareegga.
