Dantrolene Sodium Salt Hydrate CAS 14663-23-1 Tayada Sare ee Warshada API
U keeni Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: Dantrolene Sodium Salt Hydrate
CAS: 14663-23-1
Nasinta Murqaha Lafaha.Xakameeyaha Kanaalka Calcium
API Tayada Sare, Wax soo saarka Ganacsiga
| Magaca Kiimikada | Dantrolene Sodium Salt Hydrate |
| La mid ah | 1-[5-(4-Nitrophenyl)furfurylideneamino]hydantoin Sodium Salt Hydrate |
| Lambarka CAS | 14663-23-1 |
| Lambarka CAT | RF-API78 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C14H11N4NaO5 |
| Miisaanka Molecular | 338.25 |
| Solubility | Ku milmay DMSO |
| Xaalada Maraakiibta | Lagu soo raray Heer kulka jawiga |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Jaalle-Orange ilaa Orange Crystalline Powder.Ma jiro caddayn muuqata oo ku saabsan wasakhaynta walxaha shisheeye |
| Aqoonsiga A | Nuugista IR (197K) |
| Aqoonsiga B | Waqtiga haynta ee ugu sarreysa chromatogram-ka diyaarinta tijaabada waxay u dhigantaa tan ku jirta chromatogram-ka diyaarinta caadiga ah, sida lagu helay baaritaanka |
| Aqoonsiga C | Buuxiyay shuruudaha tijaabada ololka ee Sodium (191) |
| Aqoonsiga D | Qeybta 1: Waxaa la sameeyay roob mug leh, cad, crystalline Qaybta 2: Roobku ma baaba'o Qaybta 3: Da'daadu si buuxda ayay u milmaysaa Qeybta 4: Wax roobaad ah lama sameeyo |
| Waxyaalaha biyaha (waxaa qoray KF) | 14.5% ~ 17.0% |
| Cabbirka Qaybaha | 90% in ka yar 200um |
| Qiimayn | 90.0% ~ 96.0% ee C14H10N405 ku salaysan anhydrous |
| Walxaha laxidhiidha | (HPLC, Aagga%) |
| Isku dhafka A | ≤0.15% |
| Isku dhafka B | ≤0.50% |
| Isku dhafka C | ≤0.30% |
| Xalalka Haraaga ah | |
| Ethanol | ≤2000ppm |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| DMF | ≤620pm |
| Biraha culus | ≤10pm |
| Nolosha shelf | 2 sano |
| Heerka Imtixaanka | Pharmacopoeia ee Maraykanka (USP) |
| Isticmaalka | Nasinta Murqaha Lafaha.Xakameeyaha Kanaalka Calcium |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Dantrolene Sodium Salt Hydrate (CAS 14663-23-1), waa xakameyn yar oo molecule ah oo ka soo horjeeda soo dhaweynta Ryanodine iyo kanaalka Calcium.Dantrolene Sodium Salt waa nafis muruqa qalfoofka ah, kaas oo ka hortagaya intracellular Ca 2+ sii daynta reticulum sarcoplasmic.Xannibaadda Ca2 + oo laga sii daayo reticulum sarcoendoplasmic, oo si xooggan ula xidhiidha kicinta iyo murqaha muruqyada, waxay abuurtaa saameyn nasasho muruqa oo la xidhiidha Dantrolene.Neurotoxicity ay soo bandhigtay dhaqdhaqaaqa glutamate ee la sheegay waxay la xiriirtaa kor u kaca xad-dhaafka ah ee heerarka cytoplasmic Ca2 +, iyo Dantrolene ayaa sidaas awgeed loo tilmaamay inuu yahay wakiilka neuroprotective ee ka soo horjeeda neurotrasmitter-ku-soo-saarka excitotoxicity.Dantrolene, Sodium Salt waa xakameynta RyR-1 iyo RyR-3.
