Darunavir CAS 206361-99-1 Nadiifnimada Kahortagga HIV
Soo saaraha soo saarahaAlaabooyinka La Xiriira Darunavir:
Daunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Magaca Kiimikada | Darunavir |
| La mid ah | TMC114;UIC-94017 |
| Lambarka CAS | 206361-99-1 |
| Lambarka CAT | RF-API68 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C27H37N3O7S |
| Miisaanka Molecular | 547.66 |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ama Banaan-cad budada Crystalline |
| Aqoonsiga | MS/HNMR HPLC |
| Solubility | Ku milmay DMSO, Wax yar oo Biyo ah |
| Meesha dhalaalaysa | 74.0 ~ 76.0 ℃ |
| Aqoonsiga | 1H NMR |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) |
| Walxaha laxidhiidha | |
| Ugu badnaan Single Impurity | ≤0.30% |
| Wadarta wasakhda | ≤1.0% |
| Xalalka Haraaga ah | Ethanol ≤0.30% |
| Khasaare xagga qalajinta | ≤0.50% |
| Hadhaaga dabka | ≤0.10% |
| Biraha culus | ≤20pm |
| Arsenic | ≤1.5pm |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Daunavir (CAS 206361-99-1) HIV-1 Protease Inhibitor Anti-HIV |
Xidhmada: Dhalo, Bac aluminium biil ah, Durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Darunavir (magaca sumadda Prezista, oo hore loo yiqiin TMC114) waa dawo ka hortagta protease loo isticmaalo in lagu daweeyo caabuqa HIV.Darunavir waa OARAC oo lagu taliyay ikhtiyaarka daawaynta ee daawaynta-naafo iyo daawaynta khibrad u leh dadka waaweyn iyo dhalinyarada.Darunavir waa nooc cusub oo aan peptide-ka-hortagga retroviral protease inhibitors ee daawaynta AIDS-ka.Waxaa markii ugu horreysay soo saartay laanta dawooyinka Johnson ee Iceland, Tibotec.Waxay ka mid tahay bioavailability-ga ugu sarreeya ee 6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir iyo ABT378/r).Waxay u shaqaysaa iyada oo xannibaysa samaynta qaybo cusub oo baaluq ah oo ka yimaadda dusha unugyada martida loo yahay oo ay joojiso borotiinka fayraska.Marka badeecada la isticmaalo muddo dheer, waxay caadi ahaan hoos u dhigi kartaa fayraska HIV-ga ee dhiigga, kordhinta tirada unugyada CD4, waxay yareysaa fursada infekshanka HIV, waxay wanaajisaa tayada nolosha waxayna kordhisaa nolosha.Waxay ku habboon tahay dadka qaangaarka ah ee uu ku dhacay fayraska HIV laakiin aan wax saameyn ah ku yeelan isticmaalka dawooyinka lidka ku ah antiretroviral ee jira.Daawada waa in lagu daraa isticmaalka qiyaas yar oo ritonavir ah ama wakiilada kale ee ka hortagga retroviral, si loo hagaajiyo waxtarka.Dhaqdhaqaaqa ka hortagga fayraska ee vitro waxaa lagu qiimeyn karaa iyada oo laga soo horjeedo lymphocytes ba'an iyo dabadheeraad ah iyo lymphocytes ee dhiigga ku jira.
