Darunavir Ethanolate CAS 635728-49-3 Nadiifnimada
Soo saaraha soo saaraha Darunavir Alaabta la xidhiidha:
Daunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Magaca Kiimikada | Darunavir Ethanolate |
| La mid ah | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R)-3-[[(4-Aminophenyl) sulfonyl](2-methylpropyl) amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR) -hexahydrofur [2,3-b]furan-3-yl ester compd.oo leh ethanol |
| Lambarka CAS | 635728-49-3 |
| Lambarka CAT | RF-API69 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C29H43N3O8S |
| Miisaanka Molecular | 593.73 |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ama Banaan-cad budada Crystalline |
| Aqoonsiga IR | Waxay u dhigantaa Spectrum-ka caadiga ah |
| Wareeg gaar ah | -0.5°~ +0.5° |
| Walxaha laxidhiidha | (waxaa qoray HPLC) |
| Ugu badnaan Single Impurity | ≤0.20% |
| Wadarta wasakhda | ≤0.50% |
| Biyaha (KF) | ≤1.0% |
| Hadhaaga dabka | ≤0.10% |
| Biraha culus | ≤10pm |
| Waxa ku jira ethanol | ≤7.5% (GC) |
| Xalalka Haraaga ah | Methanol ≤0.30% |
| daahirnimo | ≥99.0% (HPLC) |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Xidhmada: Dhalo, Bac aluminium biil ah, Durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Darunavir Ethanolate (Prezista) waa ka hortag HIV-ga ah.Derivative of Darunavir, jiilka labaad ee HIV-1-protease inhibitor;qaab dhismeed la mid ah amprenavir.Ka hortagga fayraska.Waa shey cilmi baaris oo COVID19 la xiriira.Nasiib darro, DRV waxay leedahay milmayn hoose oo biyaha ah iyo helitaan noole oo liidata, sidaa darteed waxay u baahan tahay in la maamulo qiyaaso aad u sarreeya si loo muujiyo waxtarka daaweynta.Darunavir waa ka hortag awood ballaadhan oo firfircoon oo ka hortagga HIV-1 go'doominta bukaan-socodka oo leh cytotoxicity ugu yar.Darunavir waxay samaysaa curaarta hydrogen oo ay la socoto atamka silsiladda waaweyn ee la xafiday ee Asp29 iyo Asp30 ee borotiinka.Is dhexgalkaan ayaa la soo jeediyay in ay muhiim u yihiin awoodda xaruntan ka hortagga go'doominta HIV kuwaas oo u adkeysanaya dhowr jeer oo ka hortag ah.Daraasadda in vitro ee unugyada MT-2, awoodda darunavir waxay ka weyn tahay saquinavir, amprenavir, nelfinavir, indinavir, lopinavir iyo ritonavir.Darunavir waxaa ugu horrayn dheef-shiid kiimikaad ku sameeya cytochrome P450 (CYP) enzymes, ugu horrayn CYP3A.Qiyaasta 'kor u qaadista' ee ritonavir waxay u shaqeysaa horjooge CYP3A, sidaas darteed kordhinta bioavailability darunavir.Darunavir waxaa loogu talagalay inuu sameeyo is-dhexgal adag oo leh enzyme-ka borotiinka ee noocyo badan oo HIV ah, oo ay ku jiraan noocyada bukaannada khibradda leh ee daaweynta ee leh mutati iska caabin badan.
