Decitabine CAS 2353-33-5 daahirnimo>99.5% (HPLC) Warshada
Shanghai Ruifu Chemical Co., Ltd. waa saaraha iyo soo saaraha ugu horreeya ee Decitabine (CAS: 2353-33-5) oo leh tayo sare leh.Waxaan bixin karnaa COA, gaarsiinta adduunka oo dhan, tiro yar iyo tiro badan oo la heli karo.Haddii aad xiisaynayso alaabtan, fadlan u soo dir macluumaad faahfaahsan oo ay ku jiraan lambarka CAS, magaca badeecada, tirada noo soo dir.Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Decitabine |
| La mid ah | 5-Aza-2'-Deoxycytidine;5-Aza-1- (2-Deoxy-β-D-Ribofuranosyl) cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;ZdCyd;DAC;β-Decitabine |
| Lambarka CAS | 2353-33-5 |
| Lambarka CAT | RF2728 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C8H12N4O4 |
| Miisaanka Molecular | 228.21 |
| Meesha dhalaalaysa | 191 ℃ (dac.) |
| Xasaasi ah | Xasaasiyadda hawada, Xasaasida kulaylka |
| Solubility | Ku milmay DMSO;In yar oo Biyo ah |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ama Banaan-cad budada Crystalline |
| Aqoonsiga A | IR: Tusaalaha IR Spectrum wuxuu la mid yahay kan heerka |
| Aqoonsiga B | HPLC: RT-ka ugu sarreeya ee Xalka Tijaabada wuxuu la mid yahay kan Xalka Heerka |
| Aqoonsiga C | PXRD: Wanaagsan |
| Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) |
| Alfa | +56.0°~ 63.0° |
| Khasaare xagga qalajinta | <0.50% |
| Hadhaaga dabka | <0.10% |
| Biraha culus | <20ppm |
| Walxaha laxidhiidha | |
| α-Decitabine | <0.20% |
| Xumaanta Keliya Aan La Aqoon | <0.20% |
| Wadarta wasakhda | <0.50% |
| Xalalka Haraaga ah | |
| DMSO | <0.50% |
| Methanol | <0.30% |
| Methyl Formate | <0.05% |
| Acetonitrile | <0.041% |
| Solubility | Midab la'aan Cad 50 mg/ml, HOAc iyo H2O (1:1) Gudub |
| Heerka Imtixaanka | Heerka Ganacsiga |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
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Decitabine (CAS: 2353-33-5) (magaca ganacsiga Dacogen), ama 5-Aza-2'-Deoxycytidine.Kiimiko ahaan, waa analoogga cytidine.Decitabine waa wakiilka hypomethylating.Decitabine ayaa loo bilaabay daaweynta myelodysplastic syndromes (MDS).MDS waa cudurro dhiig-bax ah oo saameeya dhuuxa lafta taas oo keenta abuur aan waxtar lahayn iyo horumarinta unugyada dhiigga.Intaa waxaa dheer, bukaanada qaba MDS waxay leeyihiin khatar sare oo ah inay u gudbaan cudurka leukemia myeloid ba'an (AML).Daawaynta dhaqameed waxaa ka mid ah dhiig ku shubista, arrimaha koritaanka hematopoietic, iyo antibiyootiga ka hortagga, laakiin tallaabooyinkani waxay kaliya hagaajinayaan tayada nolosha oo leh saameyn shaki leh oo ku saabsan isbeddelka cudurka.Iyada oo ku-tallaalidda stem-unugga ay tahay hab dagaal badan, oo suurtagal ah in la daweeyo, da'da hore ama arrimaha kale ee adag ee caafimaadka bukaannada intooda badan ayaa ka saaraya inay tixgeliyaan doorashadan.Horumarkii ugu dambeeyay ee etiology-ga hoose ee MDS, si kastaba ha ahaatee, ayaa horseeday horumarinta fasal cusub oo xeryahooda loo yaqaan 'wakiilada demethylating''.Decitabine waxay raacdaa hordhaca guusha leh ee DNA methyltransferase inhibitor Azacitidine ee ugu horreeya.Waxay hypomethylates DNA iyada oo xannibaysa DNA methyltransferase.Waxay u shaqeysaa si la mid ah Azacitidine, inkastoo decitabine lagu dari karo oo kaliya xargaha DNA halka azacitidine lagu dhex dari karo DNA iyo RNA labadaba.Dib-u-hagaajinta cilmi-baarista: Decitabine waxaa si weyn loogu isticmaalaa bayoolaji molecular, farmashiyaha, iyo cilmi-baarista kale ee sayniska.Decitabine oo ah DNA methyltransferase inhibitor gaar ah, habka methylation DNA oo la beddeli karo, unugyada burooyinka ee unugyada caadiga ah si loo kala saaro ama u keeno apoptosis unugga buro.Si naxariis leh u fiirso in diiradda sare ee Decitabine ay ciyaari doonto saameynteeda cytotoxic: waxay joojin kartaa isku-dhafka DNA-da ee dhimashada unugyada.
