Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Warshada

Calaamadaha Khatarta Xn - Waxyeelo leh
Xeerarka Khatarta 20 - Waxyeello bay u tahay neefsashada
Sharaxaada Badbaadada 36 - Xidho dhar ilaalin ku habboon.
WGK Germany 3

Desmopressin Acetate (CAS: 16789-98-3) taas oo ah, 1-cysteine ​​​​deamination iyo 8-D-arginine halkii 8-l-arginine, oo sidoo kale loo yaqaan arginine vasopressin, waa analooga qaabdhismeedka dabiiciga ah ee arginine vasopressin, oo ka soo jeeda vasopressin, saameynteeda antidiuretic waa ka awood badan tahay oo waarta marka loo eego vasopressin, laakiin wax saameyn ah ma leh vasoconstrictor, waxyeellooyin daroogo, bukaan-socod ku-dhalasho ama cillad-daaweed ee platelet, uremia, beerka cirrhosis iyo sababaha aan la garanayn oo ay keento waqti dhiig-bax dheer;Waxaa loo isticmaali karaa si loo xakameeyo loogana hortago dhiigbaxa inta lagu jiro qaliinka yar;Central diabetes insipidus.Xaalado gaar ah, badeecadani waxay xitaa soo saari doontaa waxtarka bukaanada qaba cudurrada nidaamka kaadida dhexdhexaadka ah, oo badanaa naafo ah bukaanada qaba Nooca IIB von Willebrand cudurka.
Ficilka dawooyinka: Desmopressin Acetate waxaa ku jira desmopressin oo qaab dhismeed ahaan la mid ah arginine vasopressin.Waa farqiga u dhexeeya arginine vasopressin, badiyaa kala badh amino acid iyo D arginine si loogu beddelo L Arginine.Isbeddelladan qaab-dhismeedku waxay sii dheereeyaan muddada ficilka ee qiyaasta kiliinikada ee desmopressin iyada oo aan waxyeellooyinka soo raaca ee cadaadiska.Daraasadaha qaarkood ayaa muujiyay in saameynta anti-enuresis ay tahay mid muhiim ah, taas oo laga yaabo inay sabab u tahay kororka heerarka arginine vasopressin ee dhiigga carruurta habeenkii, ka dibna xoogga saara kaadida, hoos u dhigista mugga kaadida iyo cadaadiska xididdada dhiigga, qoorta oo yaraada iyo foosha.
Waxtarkeeda, sahlanaanta maamulka (sanka gudaha), muddada dheer ee ficilka, iyo la'aanta waxyeellooyinku waxay ka dhigaan dawada doorashada ee daaweynta sonkorowga dhexe eeinsipidus.Waxa kale oo laga yaabaa in lagu maareeyo intramuscularly si toos ah.Waxaa la door bidaa in lagu duro vasopressin iyo dawooyinka afka laga qaato si loogu isticmaalo carruurta.Waxa lagu tilmaamaa maaraynta polydipsia ku meel gaadhka ah iyo polyurias ee la xidhiidha dhaawaca, ama qaliinka, gobolka pituitary.
Isticmaalka kiliinikada: Desmopressin, sida cusbada acetate, waa analoog synthetic ee vasopressin kaas oo N terminal Cys uu ka maqan yahay shaqadiisa α-amino (1-Deamino) iyo halka Arg8 uu joogo sida D-isomer (D-Arg8) , sidaas darteed soo gaabinta ganacsiga DDAVP.Joogitaanka D-Arg iyo maqnaanshaha amine N-terminal ee qaab dhismeedka desmopressin ayaa kordhisay nolosheeda nuska ah sida ay diyaar u tahay isticmaalka afka, parenteral, ama sanka.Waxaa isticmaala dhammaan saddexdan dariiqo ee maamulka si looga hortago ama loo xakameeyo polydipsia (haraad badan), polyuria, iyo fuuq-baxa bukaanka qaba insipidus sonkorowga oo ay keento yaraanta vasopressin.Waxa kale oo loo oggolaaday daaweynta nocturnal enuresis ( sariir-qoynta ), taas oo la rumeysan yahay inay sababto maqnaanshaha wakhtiga caadiga ah ee habeenkii ee kor u kaca heerarka vasopressin.Desmopressin waxaa loo yaqaanaa inuu keeno kororka labadaba plasma factor VIII (antihemophilic factor) iyo plasminogen activator.Sidaa darteed waxaa ogolaatay FDA-da Maraykanka si loogu isticmaalo, waalid ahaan iyo sankaba, si loo yareeyo dhacdooyinka dhiigbaxa iskiis ama dhaawaca ee bukaanada qaba hemophilia A iyo nooca I Von Willebrand's disease, waase haddii waxqabadkooda plasma factor VIII uu ka weyn yahay 5%.Dhiirrigelin, buufinta sanka ee loo isticmaalo daawaynta bukaanada qaba hemophilia A iyo nooca I Von Willebrand's disease, waa 15-laab xoojinta buufinta sanka ee DDAVP;kan dambe waxa loo isticmaalaa daawaynta xanuunka macaanka insipidus.