Diethylphosphonoacetic Acid CAS 3095-95-2 daahirnimo>99.5% (HPLC) Afatinib Dimaleate Warshada Dhexe
Dhexdhexaadiyaha Keenida Kiimikada Ruifu ee Afatinib
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Magaca Kiimikada | Diethylphosphonoacetic acid |
La mid ah | 2- (Diethoxyphosphosphoryl) acetic acid;(Diethoxyphosfinyl) acetic acid;Diethyl Carboxymethylphosphonate;NSC 272281 |
Lambarka CAS | 3095-95-2 |
Lambarka CAT | RF-PI2024 |
Heerka Saamiyada | Kaydka dhexdiisa, Awoodda Wax-soo-saarka 30MT/Bishii |
Qaanuunka molecular | (C2H5O)2P(O)CH2CO2H |
Miisaanka Molecular | 196.14 |
Barta Karsan | 150 ℃/0.05 mmHg ( shidan) |
Cufnaanta | 1.220 g/ml at 25℃ ( shid) |
Tusmada Dib-u-celinta | n20/D 1.445 (lit.) |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Dareere aan Midab lahayn |
Aqoonsiga (HPLC) | Waqtiga haynta ee ugu sarraysa ee laga helay muunadda waxay ku dhex jirtaa 5% muunadda tixraaca. |
Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) |
Infrared Spectrum | Waafaqsan Qaab-dhismeedka |
Proton NMR Spectrum | Waafaqsan Qaab-dhismeedka |
Qoyaanka (KF) | <0.50% |
Wadarta wasakhda | <0.50% |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyaha Afatiib Dimaleate (CAS: 850140-73-7) |
Xidhmada: Dhalada fluorinated, 25kg/ Durbaan, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
Diethylphosphonoacetic Acid (CAS: 3095-95-2), Falimaha sida nucleophile ee falcelinta dheeriga ah ee nucleophilic ee isku dhafka epoxides-ka allene Reactant for: Stereoselectivity Studies ee falcelinta Staudinger;Samaynta Enantioselective ee diols iyada oo loo marayo epioxidation iyo falcelinta fuuq-celinta;Falcelinta Horner-Wadsworth-Emmons;Chelation-ka fog ayaa la xakameeyey Ireland-Claisen dib u habeyn;Dareen-celinta Ugi-Dieckmann ee isku-dhafka walxaha tetramic acid;Loo isticmaalo in lagu sameeyo dhex-dhexaadinta fosphonoester-ka ee falcelinta HEW intramolecular.Diethylphosphonoacetic Acid waa dhexdhexaad Afatinib Dimaleate (CAS: 850140-73-7).Afatinib Dimaleate waxa u ansixisay Maamulka Cuntada iyo Dawooyinka ee Maraykanka (FDA) 2013 si loogu daweeyo kansarka sambabada unugyada aan yarayn (NSCLC).Gaar ahaan, waxaa loo oggolaaday bukaanada soo bandhigaya burooyinka NSCLC ee metastatic kuwaas oo ay ku jiraan xuubka koritaanka epidermal (EGFR) exon deletions ama exon 21 mutations.Afatinib Dimaleate waa horjooge isku xidhan oo ah ErbB tyrosine kinases (tyk), kaas oo hoos u dhigaya calaamadaynta ErbB iyada oo la isku xidhayo aan laga noqon karin ee goobaha xidhitaanka EGFR tyk.