DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity>99.0% (GC) Warshada iibka kulul

Tan iyo markii Meenvin uu soo sheegay diyaarinta DMF-DMA (N, N-Dimethylformamide Dimethyl Acetal) ee 1956, DMF-DMA waxay noqotay reagent inta badan loo isticmaalo isku-dhafka organic.
DMF-DMA waxaa si weyn loogu isticmaalaa dhismaha shan ama lix giraanyo heterocyclic ah oo ka kooban falcelinta xidhitaanka giraanta.DMF-DMA waxay leedahay falcelin khafiif ah iyo waxsoosaar sare, gaar ahaan xeryahooda iska caabinta sare.
Qaab dhismeedka guud ee xeryahooda amide acetal waa sida soo socota:
Inta badan la isticmaalo waa DMF-DMA iyo DMF-DEA, amide acetal si fudud ayaa loo nadiifiyaa, waa la nadiifin karaa, amidine, alkylation iyo falcelinta baaskiilka.
Atomka kaarboonka dhexe ee DMF-DMA wuxuu ku xiran yahay saddex heteroatoms oo leh koronto weyn, taas oo ka dhigaysa inay leedahay firfircooni koronto oo xooggan.Marka la eego ficilka aashitada, kooxda alkoxy way fududahay in laga baxo, iyo ions togan oo leh firfircooni koronto oo xooggan ayaa la helaa.Falcelinta DMF-DMA waxay inta badan ka kooban tahay falcelinta methylation iyo falcelinta samaynta.
"Hal-carbon Syntheson" ee DMF-DMA
Dareen-celinta xidhitaanka wareegga ee ku lug leh DMF-DMA, hal atom oo kaarboon ah oo ku jira badeecada waxaa badanaa bixiya DMF-DMA, sidaas darteed DMF-DMA waxaa loo tixgelin karaa sidii kaarboon-soosaar.
Dareen-celinta esterification DMF-DMA
Esterification DMF-DMA waxay awood u siinaysaa asiidhyada karboksylic ee kala duwan inay si fudud u soo saaraan C1-20 alkyl ama aryl esters, iyo alaab-qeybiyeyaasha si fudud ayaa loo kala saari karaa iyadoo la nadiifinayo.
Adipic acid iyo DMF-DMA ayaa lagu qiyaasey 80 darajo laba saacadood.Amide acetal waa doorasho ku habboon in lagu caddeeyo qaar ka mid ah asiidhyada karboksilic ee leh caqabado adag ama xasillooni darro.
Falcelinta DMF-DMA amidination iyo ilaalinta amines aasaasiga ah
Amide acetals kaliya kama falcelin karto amines aasaasiga ah, laakiin sidoo kale amides, carbamates, sulfonamides si ay u sameeyaan curaarta hydrocarbon.
Sida: 2, 4-dimethyl aniline iyo DMF-DMA ee 80 digrii waxay si dhakhso ah uga saari karaan methanol si ay u sameeyaan isku-dhafka dimethamidine.
DMF-DMA sidoo kale waxaa loo isticmaali karaa sidii kooxda ilaalinta amine aasaasiga ah, kooxda ilaalinta amine aasaasiga ah (2 NH dhammaan ilaalinta) malaha dadka intiisa badani waxay u maleynayaan phthalyl, giraanta pyrrole, double Boc, double PMB, iwm, laakiin DMF-DMA ilaalinta aasaasiga ah amin, xaaladaha qaarkood sidoo kale waa qorshe ilaalin aad u faa'iido leh, ka ilaalinta kaliya waxay u baahan tahay TFA isku dhafan.
Amino ilaalinta - 13 sal-dhigida ilaalinta guud, waayo-aragnimada xulashada saldhiga ilaalinta, kala duwanaanta isticmaalka, xaaladaha sal-dhigida, shuruudaha ka saarida oo kooban
DMF-DMA waxay la falgashaa kooxaha methyl iyo methylene ee firfircoon si ay u sameeyaan kaarboon-kaarboon labanlaab ah
Phenylmethylation of DMF-DMA
Dareen-celinta unugyada heterocyclic ee DMF-DMA
Amide acetal oo ah ku-deeqaha kaarboonka keliya ayaa loo isticmaali karaa in lagu sameeyo isku-dhisyo kala duwan oo isku dhafan iyo walxo dabiici ah oo biomimetic ah.Iyada oo acetals amide waxaa lagu soo saari karaa: 1,2.4 triazole, 1.2, 4 triazolone, aminoheterocyclic derivatives, pyrimidine, pyrimidine, indoles, pyridine, quinoline, thiazole, oxazolone, isooxazole, 1.2, 4-triazone, pyrazine iyo pyrazine kale. of ammonia heterocyclic derivatives, sidoo kale waxaa lagu farsamayn karaa ogsijiin, xeryahooda sulfur heterocyclic.
Marka loo eego nooca fal-celinta kiimikada, codsiga amide acetal ee isku-dhafka unugyada heterocyclic waxaa loo qaybin karaa saddexda dhinac ee soo socda.
(1): amide acetal iyo amine, amide, falcelinta lipid karbamate, waxay abuuraan noocyo kala duwan oo siddo heterocyclic ah.
Amidoacetal iyo amine falcelinta dhexdhexaadinta foramidine, ka dibna falcelinta giraanta nucleophilic intramolecular si ay u abuurto heterocycles kala duwan, ama formamidine iyo hydrazine, hydroxylamine, l, 2, hal ama laba halides alkyl oo ka kooban laba kooxood oo firfircoon oo xeryahooda iyo silsilad dheer oo carbon ah, ka dibna giraanta intramolecular .
Isku-darka xeryahooda heterocyclic ee falcelinta amide acetals iyo amides, sida isku-darka l, 2,4 monotriazole derivatives.Marka hore, acetal-ku wuxuu la falgalaa amide si uu u sameeyo N, N 'tritradil, ka dibna wuxuu ku dhejiyaa phenylhydrazine si uu u sameeyo l, 2,4 monotriazol
Amide acetals waxay la falgalaan carbamic acid ama acetate si ay u sameeyaan chlorine-ka kooban giraanta heterocyclic.Dhexdhexaadiye dhexdhexaad ah oo uu sameeyay falcelinta amide acetal oo leh aminoethyl ester: nn-dimethyl-n 'alkyl-carboxymethyl formamidine, kaas oo ka falceliya hydrazine ama hydrazine la beddelay.Tusaale ahaan, diyaarinta 1,2,4 triazinone-6, isla'egta ayaa lagu muujiyay hoos.Haddii aad kaga falceliso nitro-formate waxaad helaysaa 1,2,4 triazolone-5.
Habka falcelinta samaynta 1,2,4 triazolone-5
Halabuurka 1.2.4-triazolidin-5 waa laba tallaabo.Marka hore, ethyl carbamate iyo DMF diformaldehyde acetals waxay sameeyaan dhexdhexaadiyaha Nn-dimethyl-n-ethoxy-formamidine.Marka labaad, kooxda amino ee phenylhydrazine waxay ka hortagtaa kaarboonka foramidine, taas oo lumisa -N (CH3).Dabadeed ammonia oo ku taal giraanta benzene ee u dhow phenylhydrazine waxay weerartaa kaarboonka kooxda kaarboonka, samaynta anion oksijiin, lammaanaha kelida ah ee elektarooniga ah ee ogsijiinta ayaa soo degta, luminaysa kooxda ethoxy, waxayna soo saartaa 1.2, 4-triazolone-5.
(II) Diyaarinta xeryahooda heterocyclic ee falcelinta amide acetal iyo amide
Tani waa habka ugu badan ee la soo sheego ee wasakhnimada abuurka ah tobanaankii sano ee la soo dhaafay.Ficilka amide acetal wuxuu u dhigmaa Grignard reagent, laakiin xaalada falcelinta amide acetal waa mid fudud oo fudud.
Amide acetal waxay leedahay laba kooxood oo firfircoon, falcelin sare, iyo methyl firfircoon, falcelinta methylene si ay u sameeyaan dhexdhexaadiyeyaasha amidine, waxay noqon kartaa falcelin dheeraad ah, xiritaanka giraanta, iyo falcelinta Grignard iyo falcelinta methylene, oo kaliya dhererka silsiladda kaarboon, ma noqon karto falcelin dheeraad ah.Tusaale ahaan, isku-dubarid ka-soo-baxyada furanochroone.
(3): amide acetal iyo hydroxyl, falcelinta isku dhafka sulfhydryl si loo dhaliyo oksijiin, xeryahooda heterocyclic sulfur
Isku-dhafka kore ee furohutanone waa tusaale wanaagsan oo ka mid ah jiilka acetal ee derivatives enamine iyo kooxda hydroxyl iyadoo la kala saarayo cirifka endolateral, taasoo keentay heteramine-ka kooban oksijiin:.Tusaale kale: catechol iyo DMF -- DMA waxay sameeyaan siddo ka kooban ogsijiin marka ay jirto dichloromethane.
Dareen-celinta DMF -- DMA iyo o-mercaptoaniline waxay soo saari karaan sulfur-ka kooban giraanta heterocyclic, qaabka falcelinta waa sida soo socota
Daraasadda kiis ee DMF-DMA falcelinta xidhitaanka giraanta iyo falcelinta shakhsi ahaaneed
(1) Batcho-Leimgruber indole synthesis
Diyaarinta noocyada kala duwan ee Vindol ee o-nitrotoluene.
Habka falcelinta
Ugu horreyntii, dimethylformamide dimethylacetal, ions taban ee kooxda methoxy waxay ka tagaan si ay u soo saaraan dhexdhexaadiye firfircoon.Waxaa lagu weeraraa carboanions ka sameysan deprotonation of o-nitrotoluene methyl hydrogen waxayna lumisaa methanol si ay u hesho enylamine-ka kor ku xusan.Wax soo saarka tillaabadan, enamine, waxay u egtahay alkene leh wax-soo-saar elektaroonig ah iyo beddelaad ku-deeqaha elektarooniga ah oo ku dheggan labada dhinac (Push-pull olefin waa mid xooggan oo polar ah oo inta badan casaan madow ah sababtoo ah kala duwanaanshaha isku-xidhka weyn ee molecule-ka. Tallaabada labaad falcelinta, kooxda nitro waxaa lagu dhimaa koox amino ah, oo ay ku xigto baaskiil wadista iyo baabi'inta si loo helo badeecada ugu dambeysa.
(2) Sawirro isku dhafan oo ka soo jeeda pyridine
(3) Isku dhafka pyrazole ee ka soo jeeda