Entecavir CAS 142217-69-4 API Anti-HBV Tayada Sare ee Warshada
Soo saaraha soo saaraha oo leh nadiif sare iyo tayo xasilan
Magaca Kiimikada: Entecavir
CAS: 142217-69-4
Daawooyinka fayraska ee loo isticmaalo daawaynta Caabuqa Cagaarshowga B
API Tayada Sare, Wax soo saarka Ganacsiga
Magaca Kiimikada | Entecavir |
La mid ah | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl]-6H-purin-6-hal |
Lambarka CAS | 142217-69-4 |
Lambarka CAT | RF-API80 |
Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
Qaanuunka molecular | C12H15N5O3 |
Miisaanka Molecular | 277.28 |
Meesha dhalaalaysa | 249.0 ~ 252.0 ℃ |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline White |
Aqoonsiga IR | Noocyada nuugista infraed-ka ee muunadda tijaabada waa inay la socotaa heerka tixraaca |
Aqoonsiga HPLC | Waqtiga haynta ee muunadda imtixaanku waxay u dhigantaa heerka tixraaca |
pH | 5.5 ~ 7.5 |
Wareegga indhaha ee gaarka ah | +24.0°-+28.0° (DMF: MeOH=1:1 C=1%) |
Walxaha laxidhiidha | |
Wadarta wasakhda | ≤0.30% |
Xumaanta Keliga ah ee ugu badan | ≤0.10% |
Enantiomer | ≤0.20% |
Xalalka Haraaga ah | |
Methanol | ≤0.30% |
Dichloromethane | ≤0.06% |
n-Hexane | ≤0.029% |
Tetrahydrofuran | ≤0.072% |
N, N-Dimethylformamide | ≤0.088% |
Toluene | ≤0.089% |
Waxyaabaha Biyaha | 5.8% ~ 6.5% |
Hadhaaga dabka | ≤0.10% |
Biraha culus | ≤20pm |
Qiimayn | 98.0% ~ 102.0% (C12H15N5O3 waxaa lagu xisaabiyaa ku salaysan anhydrous |
Cabbirka Qaybaha | D90: ≤100µm |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | API, Daawooyinka ka hortagga fayraska ee loo isticmaalo daawaynta Caabuqa Cagaarshowga B |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Entecavir waa jiil cusub oo guanine nucleoside analogues daawada afka ah oo loogu talagalay daawaynta caabuqa Cagaarshowga B (HBV), inta badan daawaynta bukaanada qaangaarka ah ee qaba waxqabadka taranka fayraska iyo serum transaminase ayaa sii waday inay kordhiso, ama unugyada beerka ee loogu talagalay waxqabadka pathological ee cagaarshow B dabadheeraad ah. , hadda waa fayraska kan ugu dhaqsaha badan uguna awoodda badan, qiyaasta isku beddelka ee ugu hooseeya analogues nucleoside.Xogtu waxay muujinaysaa in kala duwan ee bukaanada qaba cagaarshow B dabadheeraad ah, oo ay ku jiraan nucleoside naive iyo nucleoside daaweeyay iyo bukaanka beerka cirrhosis, isticmaalka kiniinnada Entecavir si fiican u daaweyntu waxay xakameyn kartaa cudurka si degdeg ah oo si fudud u gaari kara daaweynta dhamaadka xaqiiqda, kuwaas oo ah fayraska cagaarshow B aan la qiyaasi karin;Iyadoo la raacayo daaweynta, qayb badan oo bukaanno ah ayaa la gaari karaa dhammaadka qanacsanaanta daaweynta, kuwaas oo ah beddelidda antigen serology, bukaannada qaarkood waxay xitaa gaari karaan habka ugu habboon ee daaweynta dhammaadka, kuwaas oo ah antigen-negative.