Entecavir Monohydrate CAS 209216-23-9 API Warshada Tayada Sare ee Kahortagga Fayraska Cagaarshowga B Caabuqa

Sharaxaad Gaaban:

Magaca Kiimikada: Entecavir Monohydrate

CAS: 209216-23-9

Muuqashada: Caddaan ama Ku dhawaad White Budada Crystalline

Daawooyinka fayraska ee loo isticmaalo daawaynta Caabuqa Cagaarshowga B

API Tayada Sare, Wax soo saarka Ganacsiga

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Sharaxaad:

Soo saaraha soo saaraha oo leh nadiif sare iyo tayo xasilan
Magaca Kiimikada: Entecavir Monohydrate
CAS: 209216-23-9
Loo isticmaalo daawaynta Caabuqa Cagaarshowga B
API Tayada Sare, Wax soo saarka Ganacsiga

Guryaha Kiimikada:

Magaca Kiimikada	Entecavir monohydrate
La mid ah	Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl] guanine Monohydrate
Lambarka CAS	209216-23-9
Lambarka CAT	RF-API79
Heerka Saamiyada	Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram
Qaanuunka molecular	C12H17N5O4
Miisaanka Molecular	295.3
Meesha dhalaalaysa	>220℃
Cufnaanta	1.81
Xaalada Maraakiibta	Lagu soo raray Heer kulka jawiga
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Caddaan ama ku dhawaad cad budada crystalline
Solubility	Si Xor Ah Ugu Milmay Dimethylformamide, In Yar Biyo, Ethanol iyo Methanol
Aqoonsiga IR	Spectrum muunadu waxay u dhigantaa heerka tixraaca
Aqoonsiga HPLC	Waqtiga haynta ee muunadda imtixaanku waxay u dhigantaa heerka tixraaca
Waxyaalaha biyaha (waxaa qoray KF)	5.5% ~ 6.5%
Wareegga indhaha ee gaarka ah	+24.0° ilaa +30.0° (DMF: MeOH=1:1 C=1%) (walax anhydrous ah)
Hadhaaga dabka	≤0.10%
Walxaha laxidhiidha
Furontecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Isku dhafka Entecavir A	≤0.10%
Najaasad kasta oo aan la cayimin	≤0.10%
Wadarta wasakhda	≤0.30%
Xalalka Haraaga ah
Methanol	≤600pm
Dichloromethane	≤300pm
Ethyl acetate	≤1000ppm
Tetrahydrofuran	≤720pm
Toluene	≤890pm
Benzyl Chloride	≤1000ppm
Khamriga Benzyl	≤1000ppm
Xadka Microbial
Wadarta Tirooyinka Aerobic	≤100cfu/g
Khamiir iyo caaryaal	≤10cfu/g
Escherichia Coli	Waa in aan la ogaan
Biraha culus	≤10pm
Qiimayn	98.0% ~ 102.0% (HPLC; ku salaysan anhydrous)
Cabbirka Qaybaha	95% qaybuhu waa inay ahaadaan 125um gudahood
Heerka Imtixaanka	Heerka Ganacsiga;USPharmacopoeia (USP) Heerka
Isticmaalka	Daawooyinka fayraska ee loo isticmaalo daawaynta Caabuqa Cagaarshowga B

Xidhmada & Kaydinta:

Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.

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Codsiga:

Entecavir Monohydrate (CAS 209216-23-9) waa daawada afka laga qaato ee ka hortagga fayraska ee loo isticmaalo daawaynta caabuqa Cagaarshowga B (HBV).Entecavir Monohydrate waa analog nucleoside ah (si gaar ah, analoogga guanine) kaas oo joojiya qorista dib u dhigista, nuqulka DNA-ga iyo qorista fayraska.Waa nooc cusub oo ah cyclopentyl acyl guanosine ka-hortagga fayraska fayraska cagaarshowga B oo leh saameynteeda farmashiyeed sida Entecavir.Waxa lagu daaweeyaa Cagaarshowga B ee dadka qaangaarka ah, kaas oo ay ku jiraan taranka fayraska ee firfircoon, kordhinta serum transaminase ALT ama nabarrada firfircoon ee laga helay beerka histology.Entecavir Monohydrate waa horjooge awood leh oo doorta HBV, oo leh EC50 ee 3.75 nM ee unugga HepG2.Entecavir waa dib-u-dejiyaha transcriptase.Waxay ka hortagtaa Fayraska Cagaarshowga B (HBV) inuu tarmo waxayna yareysaa tirada fayraska ee jirka.