Epalrestat CAS 82159-09-9 daahirnimo>99.5% (HPLC) Warshada
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Epalrestat (CAS: 82159-09-9) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, tiro yar iyo tiro badan oo la heli karo.Iibka Epalrestat,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Epalrestat |
| La mid ah | Epalrest;ONO-2235;Eabeth;Kinedak;Sorbistat;(5Z)-5-[(2E) -2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-Thiazolidineacetic acid;2-[(5Z)-5-[(E) -3-Phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid;(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazolidin-3-yl]acetic acid |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Mass |
| Lambarka CAS | 82159-09-9 |
| Qaanuunka molecular | C15H13NO3S2 |
| Miisaanka Molecular | 319.39 g/mol |
| Meesha dhalaalaysa | 222.0 ilaa 226.0 ℃ |
| Cufnaanta | 1.43±0.10 g/cm3 |
| Solubility | DMSO 2 mg/mL Biyo <1 mg/mL ethanol <1 mg/mL |
| Heerkulka Kaydinta | Qabow & Meel Qalalan (-20 ℃) |
| COA & MSDS | La heli karo |
| Qaybta | API |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Orange ilaa budada kiristaalka cas ee Orange | U hogaansama |
| Aqoonsiga | La mid ah wakhtiga haynta HPLC ee heerka | Gudub |
| Meesha dhalaalaysa | 222.0 ilaa 226.0 ℃ | 222.4 ~ 224.3 ℃ |
| Khasaare xagga qalajinta | <0.50% | 0.04% |
| Hadhaaga dabka | <0.20% | 0.03% |
| Biraha culus (Pb) | ≤20pm | <20ppm |
| Wadarta wasakhda | ≤0.50% | 0.20% |
| Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) | 99.8% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
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Heerka khatarta 6.1
Kooxda Baakadaha II
Epalrestat (CAS: 82159-09-9) waa aldose reductase inhibitor-kii labaad ee lagu soo bandhigo aduunka oo dhan iyo kii ugu horeeyay ee laga bilaabo Japan.Epalrestat waxa loo tilmaamay daawaynta neuropathy macaanka.Waxa kale oo laga baadhayaa isha xanuunka macaanka iyo nephropathy.Epalrestat waa aldose reductase inhibitor leh IC50 ee 72 nM.
Epalrestat waxay joojisaa Aldose Reductase (AR) ee ku lug leh heerka xaddidaadda heerka u beddelka gulukooska ee sorbitol ee xaaladaha hyperglycemic.Aldose reductase waxay ahayd bartilmaameedka baadhitaanada kiliinikada ee badan si loo daweeyo neuropathy sonkorowga iyo retinopathy.Epalrestat waa daawo la ansixiyay gudaha Japan iyo India, oo loo isticmaalo daawaynta neuropathy macaanka.
Epalrestat waxaa loo isticmaalaa si looga hortago, loo hagaajiyo, oo loo daweeyo neuropathy durugsan (kabuubyo, xanuun), garaaca gariir, iyo cillad wadnaha ah oo la xiriirta sonkorowga.
Epalrestat oo ah daawada wakiilkeeda waxay yaraynaysaa isku-ururinta intracellular ee fructose iyo sorbitol iyadoo dib-u-soo-celinta dib-u-celinta aldose reductase, dib u soo celisa Na +-K +-ATPase iyo dhaqdhaqaaqa inositol, waxay kordhisaa NO formation in unugyada endothelial, waxay joojisaa protein kinase C dariiqa calaamadaynta, gulukooska unugyada endothelial-adhesion sare, dhexdhexaadin neutrophil iyo endothelial adhesion factor muujinta iyo yaraynaysaa waxyaabaha carboxymethyl lysine ee bukaanada qaba sonkorowga, sidaas daaweynta cudurada sida sonkorowga iyo dhibaatooyinkiisa.
