Etravirine TMC-125 CAS 269055-15-4 Assay ≥99.0% (HPLC) API Nadiifnimada Sare ee Warshada
Soo-saare leh Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: EtravirineTMC-125)
CAS: 269055-15-4
API Tayada Sare, Wax soo saarka Ganacsiga
Magaca Kiimikada | Etravirine |
La mid ah | TMC-125 |
Lambarka CAS | 269055-15-4 |
Lambarka CAT | RF-API54 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C20H15BrN6O |
Miisaanka Molecular | 435.28 |
Cufnaanta | 1.439 g/cm3 |
Xaalada Maraakiibta | Heerkulka deegaanka hoostiisa |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Adag ee Cad |
Aqoonsiga | By IR, HPLC |
Meesha dhalaalaysa | 211.0 ~ 216.0 ℃ |
Waxyaabaha Biyaha | ≤0.50% |
Hadhaaga dabka | ≤0.20% |
Biraha culus | ≤20pm |
Xumaan Keli ah | ≤0.50% |
Wadarta wasakhda | ≤1.0% |
Qiimayn | ≥99.0% (HPLC) |
Heerka Imtixaanka | Heerka Ganacsiga |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
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Etravirine (TMC-125) (CAS 269055-15-4) waa jiilka labaad ee aan nukleoside reverse transcriptase inhibitor (NNRTI) loo isticmaalo daaweynta HIV.Waxaa loo tilmaamay in lagu daro daawooyinka kale ee ka hortagga HIV-1 ee lagu daweeyo caabuqa HIV-1 ee bukaannada qaangaarka ah ee khibradda u leh daaweynta kuwaas oo haysta caddaynta taranka fayraska iyo noocyada HIV-1 ee u adkeysanaya NNRTIs hadda la heli karo iyo wakiilada kale ee ka hortagga retroviral.NNRTIs, oo ay la socdaan nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs), waa qaybo muhiim ah oo ka mid ah hababka isku dhafka ah ee hadda loo isticmaalo in lagu daweeyo caabuqa HIV-1.NRTIs/NtRTIs waxay u dhaqmaan iyaga oo la tartamaya substrate-ka nucleotide-ka dabiiciga ah ee qoraalka qoraalka ah si loogu daro DNA-da fayraska iyo joojinta silsiladda xigta.Taas bedelkeeda, NNRTI-yadu waxay ku xidhan yihiin goobta allosteric ee ensaymka waxayna carqaladeeyaan shaqada DNA polymerase iyaga oo keenaya isbeddello is-beddel ah oo ku yimaada goobta catalytic.
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