Flurbiprofen CAS 5104-49-4 Assay 99.0 ~ 100.5% (HPLC)

Flurbiprofen
C15H13FO2 244.27
(±)-2-(2-Fluoro-4-biphenylyl)propionic acid [5104-49-4].
Flurbiprofen waxa uu ka kooban yahay wax aan ka yarayn 99.0 boqolkiiba oo aan ka badnayn 100.5 boqolkiiba C15H13FO2, oo lagu xisaabiyo hab qallalan.
Baakadaha iyo kaydinta- Ku kaydi weelal cidhiidhi ah.
Heerarka Tixraaca USP <11>-
USP Flurbiprofen RS
Isku dhafka USP Flurbiprofen A RS
2- (4-Biphenylyl) Propionic acid.
C15H14O2 226.28
Aqoonsiga -
J: Nuugista Infrared <197K>.
B: Nuugista Ultraviolet 197U-
Xalka: 10 µg halkii ml.
Dhexdhexaad: 0.1 N sodium hydroxide.
Nuugista ugu badan ee 247 nm waa qiyaastii 0.8.
Kala duwanaanshaha dhalaalka <741>: inta u dhaxaysa 114 iyo 117.
Luminta qalajinta <731>-Ku qalaji faakuumka 60 ilaa miisaan joogto ah: waxay luminaysaa wax aan ka badnayn 0.5% miisaankeeda.
Hadhaaga dabka <281>: aan ka badnayn 0.1%.
Biraha culus, Habka II <231>: 0.001%.
Iskudhisyada la xidhiidha-
Diluent-diyaari isku dhafka biyaha iyo acetonitrile (11:9).
Marxaladda wareegta- Diyaari isku dhafka biyaha, acetonitrile, iyo glacial acetic acid (12:7:1).Samee hagaajin haddii loo baahdo (eeg Habboonaanta Nidaamka ee hoos timaada Chromatography <621>).
Xalka saamiga caadiga ah- Kala mii tirada saxda ah ee la miisaamay ee USP Flurbiprofen La xidhiidha Isku-dhafka A RS ee Diluent si loo helo xal isagoo ku urursan 50 µg halkii ml.
Xalka ku habboonaanta nidaamka-Pipet 2.0 mL of Standard stock stock geli 10-mL weel mug leh, ku dar qiyaastii 20 mg USP Flurbiprofen RS, ku milmi Diluent si mug, iyo qas.
Xalka caadiga ah-Ku wareeji 2.0 mL ee xalalka caadiga ah una wareeji 10.0-mL weel mug leh, ku milmi Diluent ilaa mug, oo qas.
Tijaabi xal-ku diyaari xal Flurbiprofen ah oo ku jirta Diluent oo ka kooban 2.0 mg halkii ml.
Nadaamka Chromatographic (eeg Chromatography <621>)-Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay 254-nm detector iyo tiir 3.9-mm × 15-cm ah oo ka kooban 4-µm xirmo L1.Heerka socodka waa qiyaastii 1 mL daqiiqadii.Chromatograph ee xalka ku habboonaanta Nidaamka, oo qor jawaabaha ugu sarreeya sida lagu faray Habraaca: waqtiyada haynta qaraabo waxay ku dhow yihiin 0.9 ee xarunta la xidhiidha Flurbiprofen A iyo 1.0 ee flurbiprofen;iyo leexashada heerka qaraabo ee cirbadaha soo noqnoqda kama badna 1.0%.
Habka-Si gooni ah u duri mugga siman (qiyaastii 20 µL) ee xalka caadiga ah iyo xalka Imtixaanka chromatograph-ka, duub chromatogram-yada, oo cabbir meelaha ugu sarreeya.Xisaabi boqolleyda isku-dhafka flurbiprofen A ee qaybta Flurbiprofen ee ay qaadatay qaacidada:
100 (CS / CU) (rU / rS)
kaas oo CS uu yahay fiirsashada, µg halkii ml, ee USP Flurbiprofen Isku-xidhka A RS ee xalalka caadiga ah;CU waa fiirsashada, µg halkii ml, ee Flurbiprofen ee xalka tijaabada;iyo rU iyo rS waa jawaabaha ugu sarreeya ee iskudarka la xidhiidha flurbiprofen A ee laga helay xalinta tijaabada iyo xalalka caadiga ah, siday u kala horreeyaan: in aan ka badnayn 0.5% ee isku xidhka flurbiprofen A ayaa la helay.Xisaabi boqolkiiba wasakh kasta ee qaybta Flurbiprofen ee ay qaadatay qaacidada:
100 (ri / rs)
taas oo ri ay tahay jawaabta ugu sarreysa ee wasakh kasta oo laga helo xalka Imtixaanka;iyo rs waa wadarta jawaabaha dhammaan meelaha ugu sarreeya ee laga helay xalka Tijaabada: wadarta dhammaan wasakhyadu kama badna 1.0%.
Assay-Dissolve oo ku saabsan 0.5 g of Flurbiprofen, oo si sax ah loo miisaamay, 100 mL oo aalkolo ah, oo hore loogu dhex daray 0.1 N sodium hydroxide VS ilaa phenolphthalein dhamaadka, ku dar phenolphthalein TS, iyo titrate leh 0.1 N sodium hydroxide VS muuqaalka ugu horreeya ee daciifka ah. midab casuus ah oo soconaya wax aan ka yarayn 30 ilbiriqsi.ML kasta oo ah 0.1 N sodium hydroxide waxay u dhigantaa 24.43 mg ee C15H13FO2.