Fmoc-Ile-OH CAS 71989-23-6 Fmoc-L-Isoleucine Nadiifinta>99.0% (HPLC) Warshada

Fmoc-L-Isoleucine (Fmoc-Ile-OH) (CAS: 71989-23-6) waa soosaar isoleucine, waa amino acid aan dabiici ahayn oo loo isticmaalo peptidomimetics.Fmoc-L-isoleucine waa Nα-9-fluorenylmethoxycarbonyl-amino acid.9-fluorenylmethoxycarbonyl waa koox muhiim ah oo ilaalinta amino ee isku dhafka peptide.Sababtoo ah waa koox ilaalin xasaasi ah oo saldhig u ah waxayna ku xasilloon tahay shuruudaha loo isticmaalo in laga saaro kooxaha ilaalinta caadiga ah, waxay leedahay door gaar ah oo ku saabsan isku-dhafka polypeptide.Dhismaha caadiga ah ee isku dhafka peptide wejiga adag ee joogtada ah ee raacaya Fmoc-tactics.
Fmoc-amino acids, oo loo isticmaalo isku-dhafka peptide, oo loo isticmaalo sida dhexdhexaadinta isku-dhafka organic, dhexdhexaadinta daawada, reagent biochemical ama reagent kiimikaad.
Diyaarinta L-Isoleucine (CAS: 73-32-5) 1.05g (0.008 mol) ee adkaha ah ayaa lagu kala direy 10% sodium carbonate xal, L-isoleucine adag ayaa si ku filan u milmay by walaaqaya.At 20 ~ 30 ℃, 9-fluorenylmethoxycarbonyl chloride (205g) ku milmay toluene (2 ~ 2.10) ayaa lagu daray dropwise, 0.008 mol) xal, Dropwise ku daray 30 ~ 60 daqiiqo, dhamaadka isku darka, at 20 ~ 30 C walaaqaya 1. ~ 8 saacadood, ku dar 30 ~ 200 ml oo biyo ah, oo leh n-butyl acetate (80 ml) oo ka badan 9-fluorenylmethoxycarbonyl chloride ayaa laga saaray soo saarista, marxaladda aqueous-ka soo baxday waxaa lagu daray acid hydrochloric acid PH = 0.5 ~ 3.5, ka dibna oo lagu soo saaray n-butyl acetate (80 ml), iyo marxaladda saliidda ee soo baxday waxaa lagu dhaqay biyo si looga saaro hydrochloric acid, marxaladda saliidda ayaa la saaray si looga saaro dareeraha n-butyl acetate, crystals cad oo soo da'ay, la sifeeyay oo la qalajiyey si loo siiyo alaabta. Fmoc-L-Isoleucine 2.48g, dhalid 87.9%, dhibic dhalaalaysa: 140.0 ~ 155.0 ℃.