Fondaparinux Sodium CAS 114870-03-0 API

Sharaxaad Gaaban:

Magaca Kiimikada: Fondaparinux Sodium

CAS: 114870-03-0

Muuqashada: Caddaan ilaa budo cad-cad

Qiimaynta: 95.0% ~ 103.0% (oo ku salaysan qalalan)

Daawada xinjirowga lidka ku ah xinjirowga lidka ku ah, oo ah Factor Xa inhibitor

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Sharaxaad:

U keeni Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: Fondaparinux Sodium
CAS: 114870-03-0
Daawada xinjirowga lidka ku ah xinjirowga lidka ku ah, oo ah Factor Xa inhibitor
API Tayada Sare, Wax soo saarka Ganacsiga

Guryaha Kiimikada:

Magaca Kiimikada	Fondaparinux sodium
Lambarka CAS	114870-03-0
Lambarka CAT	RF-API84
Heerka Saamiyada	Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram
Qaanuunka molecular	C31H43N3O49S8.10Na
Miisaanka Molecular	1728.08
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Caddaan ilaa budo cad-cad
Habka Qiimaynta / Falanqaynta	95.0% ~ 103.0% (oo ku salaysan qalalan)
Solubility	Si Xor Ah Ugu Sollaysan Biyaha, 2.0M Sodium Chloride iyo 0.5M Sodium Hydroxide
Aqoonsiga 13C-NMR	Resonances for Fondaparinux Sodium waa in lagu eego 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7.7mpp.Isbeddellada kiimikaad ee calaamadahani kama duwana in ka badan ± 0.3ppm calaamadaha kale ee dhererka isbeddelka iyo isbeddelada kiimikada, oo loo aaneynayo Fondaparinux Sodium, laga yaabo in lagu arko inta u dhaxaysa 58.0 ~ 80.5 ppm iyo 98.7 ~ 104.5ppm
Aqoonsiga HPLC	Waqtiga haynta ee ugu sarreeya ee xalka muunadda ayaa u dhigma kan xalka caadiga ah
Aqoonsiga AAS	Soodhiyamku waa inuu lahaadaa nuugista sifo ah 330.2nm iyadoo la raacayo go'aaminta sodium
pH	6.0-8.0
Sodium (Na)	11.5% ~ 15.0% (waxaa lagu xisaabiyaa anhydrous iyo dareerayaasha bilaashka ah)
Sulfate bilaash ah	≤0.30%
Haraaga Chloride	≤1.00%
Walxaha laxidhiidha
Xumaanta A	≤0.80%
Xumaanta B	≤0.60%
Xumaan Kale Oo Keliya	≤0.30%
Wadarta wasakhda	≤2.00%
Xalalka Haraaga ah
Methanol	≤3000pm
Ethanol	≤5000ppm
Ethyl acetate	≤5000ppm
DMF	≤880pm
Methylbenzene	≤890pm
Pyridine	≤50pm
Waxyaabaha Biyaha (KF)	≤15.0%
Bakteeriyada Endotoxins	≤3.3EU/mg
Xadka Microbial	Tirada guud ee noolaha yaryar ≤100cfu/g
Heerka Imtixaanka	Heerka Ganacsiga;USPharmacopoeia (USP) Heerka
Isticmaalka	API, Daawada xinjirowga lidka ku ah xinjirowga lidka ku ah, Factor Xa Inhibitor

Xidhmada & Kaydinta:

Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.

Faa'iidooyinka:

FAQ:

Codsiga:

Fondaparinux Sodium (CAS 114870-03-0) waa kan ugu horreeya ee fasalka cusub ee xinjirowga lidka ku ah xinjirowga lidka ku ah kiimikaad ee la xiriirta heparinnada miisaanka kelli ee hooseeya (LMWH).Fondaparinux sodium waa factor Xa inhibitor si ay u sameeyaan goobta xidhidhnimo sare ee anti-coagulant factor antithrombin III (ATIII).Fondaparinux sodium ku xidhitaanka goobtan waxay xoojisaa saamaynta dabiiciga ah ee ka hortagga ATIII ee ka dhanka ah factor Xa by arrin qiyaastii 300, taas oo keenta in la joojiyo jiilka thrombin.Waxaa suuqgeeyay GlaxoSmithKline.Nooc guud oo ay soo saartay Alchemia ayaa lagu suuq geeyaa gudaha Maraykanka Dr. Reddy's Laboratories.Fondaparinux sodium ayaa markii ugu horreysay lagu soo bandhigay Maraykanka si looga hortago xinjirowga xididdada qotodheer taasoo laga yaabo inay keento sambabada sambabada ka dib qalliinka weyn ee lafaha.Unugyadan gebi ahaanba synthetic molecule waa nuqul ka mid ah isku xigxiga heparin pentasaccharide, jajabka ugu gaaban ee awood u leh inuu kiciyo xannibaadda antithrombin lllmediated ee factor Xa taas oo ka hortagaysa jiilka thrombin iyada oo aan ficil antithrombin ah.