Gemcitabine CAS 95058-81-4 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Gemcitabine (CAS: 95058-81-4) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Gemcitabine,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Gemcitabine |
| La mid ah | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5- (Hydroxymethyl) oxolan-2-yl] pyrimidin-2-hal;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine |
| Heerka Saamiyada | Kaydka dhexdiisa, Awoodda Wax-soo-saarka 5 Tan |
| Lambarka CAS | 95058-81-4 |
| CAS la xidhiidha | 122111-03-9 |
| Qaanuunka molecular | C9H11F2N3O4 |
| Miisaanka Molecular | 263.20 g/mol |
| Meesha dhalaalaysa | 217.0 ilaa 222.0 ℃ |
| Cufnaanta | 1.84± 0.10 g/cm3 |
| Xasaasi ah | Xasaasida kulaylka |
| Biyuhu milmayn | Dhaqan ahaan Aan Biyo Ku milmin |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Caddaan ama Ku dhawaad Caddaan budada Crystalline, oo aan ur lahayn | U hogaansama |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Xumaanta Shaqsiga ah | ≤0.10% | 0.03% |
| Wadarta wasakhda | ≤1.00% | 0.10% |
| Biyaha waxaa qoray Karl Fischer | ≤1.00% | 0.67% |
| Wareeg gaar ah | +68.0°~+74.0° | +70.5° |
| Biraha culus | ≤10pm | <10pm |
| Hadhaaga dabka | ≤0.10% | 0.03% |
| Qiimaynta (Waxaa qoray HPLC) | 98.0% ~ 102.0% | 99.9% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi bakhaar qabow, engegan oo hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka fogow soo-gaadhista iftiinka qorraxda tooska ah, qoyaanka iyo kulaylka badan.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
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Faa'iidooyinka?Tayada sare, qiimo jaban, adeegyo xirfadeed iyo taageero farsamo, gaarsiin degdeg ah.
TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.
Tusaalooyinka?Badeecadaha intooda badani waxay bixiyaan muunado bilaash ah oo loogu talagalay qiimeynta tayada, kharashka dhoofinta waa in ay bixiyaan macaamiisha.
Hantidhawrka Warshada?Hantidhawrka warshada soo dhawoow.Fadlan horay u sii ballan.
MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.
Gaadiidka?By Express (FedEx, DHL), hawada, badda.
Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
Isku-dhafka gaarka ah?Waxay ku siin kartaa adeegyada isku-dhafka gaarka ah si ay ugu habboonaato baahiyahaaga cilmi-baarista.
Shuruudaha Lacag-bixinta?Qaansheegga Proforma ayaa marka hore la soo diri doonaa ka dib marka la xaqiijiyo dalabka, oo lagu soo lifaaqay macluumaadka bangigayaga.Lacag bixinta T/T (Telex Transfer), PayPal, Western Union, iwm.
Xeerarka Khatarta R21 - Waxyeelo u leh taabashada maqaarka
R36/38 - Waxay ka xanaajisaa indhaha iyo maqaarka.
R46 - Waxa laga yaabaa inay keento dhaawac hidde ah oo la iska dhaxlo
R62 - Khatarta suurtagalka ah ee dhalmo la'aanta
R63 - Khatarta suurtagalka ah ee waxyeelada ubadka aan dhalan
Sharaxaada Badbaadada S25 - Ka fogow taabashada indhaha.
S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad.
S36/37 - Xidho dhar difaac ku haboon iyo galoofyada.
S53 - Iska ilaali soo-gaadhista - hel tilmaamo gaar ah kahor isticmaalka.
HS code 2934999091
Sunta LD10 iv ee jiirka: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) waa daawaynta kiimikaad ee loo isticmaalo daawaynta noocyo badan oo kansar ah.Tan waxaa ku jira kansarka naasaha, kansarka sambabada unugyada aan yareyn, kansarka ganaca, kansarka kaadiheysta, iyo kansarka mareenka biliary.Gemcitabine ayaa lagu baarayaa in loo isticmaalo kansarka hunguriga, waxaana si tijaabo ah loogu isticmaalaa lymphomas iyo noocyo kale oo burooyin ah.Gemcitabine waxaa lagu maamulaa dariiqa xididada, maadaama ay si weyn u dheefshiido mareenka caloosha iyo mindhicirka.
Gemcitabine waa analooga nucleotide, kaas oo iska leh fasalka anti-metabolic ee daawooyinka kansarka.Waxay inta badan ku shaqeysaa marxaladda isku dhafka DNA, taas oo ah, marxaladda S.Xaaladaha qaarkood, waxay ka hortagi kartaa marxaladda G1 inay u gudubto marxaladda S.Waxay leedahay sifooyinka spectrum anticancer ballaaran, habka gaarka ah ee ficilka, sunta hoose, iska caabbinta daawooyinka kale ee kemotherabi iyo ma jirto meel sare oo sun ah.Kiimikada, gemcitabine, ayaa hadda loo oggolaaday in laga isticmaalo in ka badan 90 waddan, taasoo ka dhigaysa daawaynta safka koowaad ee kansarka sambabada unugyada yaryar iyo "heerka dahabka" ee kansarka ganaca.
1999kii, CFDA waxay ansixisay gemcitabine daawaynta NSCLC gudaha ama metastatic, deegaanka horumaray ama kansarka beeryarada;Sannadkii 2010, CChemicalbookFDA waxa ay ansixisay gemcitabine oo ay weheliso paclitaxel si loogu daweeyo kansarka naasaha ee aan la dami karin, deegaanka soo noqnoqda ama metastatic kaas oo soo noqnoqday ka dib daaweynta adjuvant/neoadjuvant chemotherapy.
Gemcitabine waa antimetabolite-balaadhan iyo analooga deoxycytidine oo leh firfircoonida antineoplastic.Marka la maamulo, gemcitabine waxaa loo beddelaa metabolites firfircoon difluorodeoxycytidine diphosphate (dFdCDP) iyo difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase.dFdCTP waxay la tartantaa deoxycytidine triphosphate (dCTP) waxaana lagu daray DNA.Tani waxay qufulaysaa DNA polymerase taas oo keenta in wajiga la joojiyo inta lagu guda jiro taranka DNA.Dhanka kale, dFdCDP waxay joojisaa ribonucleotide reductase, taas oo hoos u dhigaysa barkada deoxynucleotide ee diyaar u ah isku dhafka DNA.Hoos-u-dhaca ku-soo-ururinta unugga-galaha ee dCTP waxay xoojisaa ku-daridda dFdCTP ee DNA-da.
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