Guanfacine Hydrochloride Guanfacine HCl CAS 29110-48-3 API USP Nadiifnimada Sare
Soo-saare leh Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: Guanfacine Hydrochloride
La mid ah: Guanfacine HCl
CAS: 29110-48-3
Guanfacine Hydrochloride waa agonist α2A-adrenoceptor ah oo la doortay.Antihypertensive
API Tayada Sare, Wax soo saarka Ganacsiga
Magaca Kiimikada | Guanfacine Hydrochloride |
La mid ah | Guanfacine HCl |
Lambarka CAS | 29110-48-3 |
Lambarka CAT | RF-API40 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C9H10Cl3N3O |
Miisaanka Molecular | 282.55 |
Meesha dhalaalaysa | 211.0 ~ 215.0 ℃ |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Aqoonsiga | Nuugista Infrared;HPLC |
Khasaare xagga qalajinta | ≤0.50% |
Hadhaaga dabka | ≤0.10% |
Biraha culus | ≤20pm |
Qiimayn | 98.0% ~ 102.0% (HPLC ku salaysan qalalan) |
Nadiifnimada Chromatographic | ≥99.0% |
Heerka Imtixaanka | Heerka USP |
Isticmaalka | Walaxda Farmashiyeedka Firfircoon (API) |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa saaraha iyo soo saaraha ugu horreeya ee Guanfacine Hydrochloride (CAS: 29110-48-3) oo leh tayo sare.
Guanfacine hydrochloride waxay u shaqeysaa xudunta u ah a-adrenoceptor agonist.Antihypertensive.Guanfacine hydrochloride, wakiilka anti-hypertensive, waa α2A-adrenoceptor agonist oo leh Kd of 31 nM wuxuuna muujiyaa xulashada 60-laab ee ka sarreeya α2B-adrenoceptors.Guanfacine waxay hoos u dhigtaa cadaadiska dhiigga ee systolic iyo diastolic labadaba iyadoo dhaqaajisa habka dhexe ee neerfayaasha α2A norepinephrine autoreceptors, taas oo keenta hoos u dhac ku yimaada qulqulka naxariista ee durugsan sidaas darteed hoos u dhigista codka naxariista ee durugsan.Codsiyada daweynta ee guanfacine waxay la mid yihiin kuwa kale ee dhexdhexaadka ah ee α2-adrenergic agonists iyo methyldopa.Waxay wax ku ool u noqotay monotherapy ahaan daaweynta bukaanada qaba hypertension fudud ilaa dhexdhexaad.