Ibrutinib CAS 936563-96-1 daahirnimo>99.5% (HPLC) API

Sharaxaad Gaaban:

Magaca Kiimikada: Ibrutinib

CAS: 936563-96-1

Daahirsanaanta:>99.5% (HPLC)

Muuqashada: Caddaan ilaa cad-cad budada Crystal

Ibrutinib waa BTK inhibitor loo isticmaalo daawaynta Chronic Lymphocytic Leukemia (CLL) iyo Mantle Cell Lymphoma (MCL)

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Sharaxaad:

Dhexdhexaadiyeyaasha la xidhiidha Ibrutinib:
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxyphenylboronic Acid CAS 51067-38-0
Ibrutinib Dhexdhexaad N-2 CAS 330786-24-8
Ibrutinib Dhexdhexaad N-3 CAS 330792-70-6
Ibrutinib CAS 936563-96-1

Guryaha Kiimikada:

Magaca Kiimikada	Ibrutinib
La mid ah	1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1- mid;PCI-32765
Lambarka CAS	936563-96-1
Heerka Saamiyada	Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan
Qaanuunka molecular	C25H24N6O2
Miisaanka Molecular	440.50
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada Crystal White ilaa Cadaan
Aqoonsiga	IR;HPLC
Khasaare xagga qalajinta	<0.50%
Hadhaaga dabka	≤0.10%
Biraha culus (sida Pb)	≤20pm
Xumaan Keli ah	≤0.20%
Wadarta wasakhda	<0.50%
Daahirnimada / Habka Falanqaynta	> 99.5% (HPLC)
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	API

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.

Faa'iidooyinka:

FAQ:

Codsiga:

Ibrutinib (CAS: 936563-96-1) waa horjooge Bruton tyrosine kinase (BTK) oo loogu talagalay daaweynta leukemia lymphocytic chronic (CLL) iyo mantle cell lymphoma (MCL).Labada MCL iyo CLL waxay ka tirsan yihiin unugyada B-cell non-Hodgkin's lymfoma, taas oo ah mid soo noqnoqota oo u nugul soo noqoshada.Dawaynta kiimikaad ee sida caadiga ah loo isticmaalo laguma bar-tilmaameedsan, iyo fasalka 3 ama 4 falcelin xun ayaa inta badan dhaca.Ibrutinib waxay ku dari kartaa BTK, taas oo lagama maarmaan u ah samaynta, kala-duwanaanta, isgaarsiinta iyo badbaadada B-lymphocytes, waxayna si aan leexleexad lahayn u joojinaysaa dhaqdhaqaaqa BTK, si wax ku ool ah u xakameysa faafinta iyo badbaadada unugyada burooyinka.Intaa waxaa dheer, si degdeg ah ayaa loo nuugo ka dib maamulka afka, qiyaasta ugu badan ee plasma ayaa la gaarey 1 ~ 2h, iyo falcelinta xun waa fasalka 1 ama 2, taas oo noqon doonta doorasho cusub oo loogu talagalay daaweynta CLL iyo MCL.Noofambar 13, 2013, US FDA si ay u dardargeliso shirkadda Johnson & Johnson ee la ansixiyay iyo Maraykanka Imbruvica (magaca guud: Ibrutinib) ee daaweynta lymphoma unugyada mantle (MCL).Ibrutinib, waxaa siisay heerka daawaynta horumarsan ee FDA bishii Febraayo 2013 waxaana loo oggolaaday MCL Noofambar 13, 2013 iyo CLL Febraayo 12, 2014, siday u kala horreeyaan.