N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS 152460-09-8 Imatinib Mesylate Dhexdhexaad Sare nadiif ah
Sahayda Ganacsiga Imatinib Mesylate iyo Dhexdhexaadiyayaasha la xidhiidha:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl] benzoic acid dihydrochloride CAS: 106261-49-8
Magaca Kiimikada | N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine |
La mid ah | Imatinib Mesylate Intermediate;2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine |
Lambarka CAS | 152460-09-8 |
Lambarka CAT | RF-PI228 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C16H13N5O2 |
Miisaanka Molecular | 307.31 |
Meesha dhalaalaysa | 188.0-193.0 ℃ |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Jaalle ama ku dhawaad budada jaalaha ah |
daahirnimo | ≥98.0% (HPLC) |
Qoyaanka (KF) | ≤0.50% |
Wadarta wasakhda | ≤2.0% |
Xumaanta Keliga ah ee ugu badan | ≤1.0% |
Hadhaaga dabka | ≤0.50% |
Biraha culus | ≤20pm |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadka Imatinib Mesylate (CAS: 220127-57-1) |
Xidhmada: Dhalo, boorsada bireed aluminium, durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
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Shanghai Ruifu Chemical Co., Ltd. waa saaraha iyo soo saaraha ugu horreeya ee N- (2-Methyl-5-nitrophenyl) -4- (pyridin-3-yl) pyrimidin-2-amine (CAS: 152460-09-8) tayo sare leh.Waa dhex dhexaad caadi ahaan ku jira isku-dhafka Imatinib Mesylate (CAS: 220127-57-1).
Imatinib Mesylate waa unug yar oo ka hortagaya c-Abl protein-tyrosine kinase, Aad u gaar ah BCR-ABL, enzyme la xidhiidha kansarka myelogenous leukemia (CML) iyo noocyo gaar ah oo lymphoblastic leukemia ba'an (ALL).Dhacdo tarjumaad ah oo u dhaxaysa koromosoomyada 9 iyo 22 waxay soo saartaa koromosoomyada Philadelphia, ka dibna waxay soo saartaa borotiinka fusion Bcr-Able leh firfircoonida kinase aberrant taasoo kor u qaadaysa kororka unugyada degdega ah.Imatinib Mesylate wuxuu xiraa kinase-kan muhiimka ah, isagoo joojinaya koritaanka CML ee la xiriira.Imatinib Mesylate ayaa sidoo kale la soo bandhigay si loo joojiyo PDGFR iyo tyrosine kinases ee la xidhiidha c-Kit.Daawooyinka ka kooban Imatinib Mesylate ayaa loo isticmaalay daawaynta kansarrada kala duwan.