N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Dhexdhexaad Sare nadiif ah

Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha iyo soo saaraha ugu horreeya ee N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) oo leh tayo sare leh .
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) waa dhexdhexaad caadi ahaan isku-dhafka imatinib Mesylate (CAS: 220127-57-1) ) API.
Imatinib mesylate waa unug yar oo ka hortagaya c-Abl protein-tyrosine kinase, kinase si gaar ah muhiim ugu ah badinta leukemia myelogenous chronic (CML).Dhacdo tarjumaad ah oo u dhaxaysa koromosoomyada 9 iyo 22 waxay soo saartaa koromosoomyada Philadelphia, ka dibna waxay soo saartaa borotiinka fusion Bcr-Able leh firfircoonida kinase aberrant taasoo kor u qaadaysa kororka unugyada degdega ah.Imatinib mesylate waxay xirtaa kinase-kan muhiimka ah, joojinta korriinka CML ee la xiriira.Imatinib mesylate ayaa sidoo kale la soo bandhigay si loo joojiyo PDGFR iyo tyrosine kinases ee la xidhiidha c-Kit.Daawooyinka ay ku jiraan Imatinib mesylate ayaa loo isticmaalay daawaynta kansarro kala duwan.
Imatinib mesylate waa tyrosine kinase inhibitor.Si gaar ah u gaar ah BCR-ABL, enzyme-ka la xidhiidha leukemia-da 'myelogenous leukemia' (CML) iyo noocyo gaar ah oo leukemia ba'an ah (ALL).Waa v-Abl tyrosine kinase inhibitor ah oo awood leh oo door ah (IC50 = 38 nM).Sidoo kale waxay joojisaa PDGFR iyo c-kit.Waxay muujisaa xulashada v-Abl oo ka sarreysa guddi ka kooban tyrosine kale iyo serine/threonine protein kinases.Waxay si xushmad leh u joojisaa korriinka kicinta ee PDGF ee unugyada V-abl-beddelay ee PB-3 iyo v-sis-beddelay unugyada BALB/c 3T3 ee vitro.Waxay muujisaa saamaynta antitumor ee jiirarka sida AMuLV ama unugyada BABL/c 3T3 v-sisWaxay joojisaa ku-noqoshada SARS-CoV iyo MERS-CoV in vitro (qiimaha EC50 waa 9.823 iyo 17.689 μM, siday u kala horreeyaan).