Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory Tayada Sare
Sahayda Ganacsiga Imatinib Mesylate iyo Dhexdhexaadiyayaasha la xidhiidha:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl] benzoic acid dihydrochloride CAS: 106261-49-8
| Magaca Kiimikada | Imatinib Mesylate (qaabka alfa) |
| La mid ah | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Lambarka CAS | 220127-57-1 |
| Lambarka CAT | RF-API19 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C30H35N7O4S |
| Miisaanka Molecular | 589.71 |
| Xaalada Maraakiibta | Heerkulka deegaanka hoostiisa |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
| Solubility | Way fududahay in lagu milmo biyaha |
| Aqoonsiga HPLC | Tusaalaha spectrum spectrum wakhtiga haynta ugu badan waa taas |
| Aqoonsiga IR | Noocyada nuugista infrared ee muunada waxay waafaqsan tahay muunada tixraaca |
| Meesha dhalaalaysa | 214.0 ~ 222.0 ℃ |
| Khasaare xagga qalajinta | ≤0.50% |
| Hadhaaga dabka | ≤0.10% |
| Biraha culus | ≤20pm |
| Walxaha laxidhiidha | (1) Nijaasnimo G: NMT 0.3% |
| (2) wasakhda B: NMT 0.3% | |
| (3) Xumaan C: NMT 0.3% | |
| (4) Xumaan D: NMT 0.3% | |
| (5) wasakh A: NMT 0.3% | |
| (6) wasakhda H: NMT 0.3% | |
| (7) Nijaasnimo F: NMT 0.3% | |
| (8) wasakhda E: NMT 0.3% | |
| (9) Najaasadda keliya ee ugu weyn: NMT0.1% | |
| Xalalka Haraaga ah | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| HPLC Assay | 98.0% ~ 102.0% (C30H35N7SO4 Lagu Xisaabiyay Asal ahaan Anhydrous) |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API;Ph+CML |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Imatinib Mesylate (CAS 220127-57-1) waa unug yar oo ka hortagaya c-Abl protein-tyrosine kinase, kinase oo si gaar ah muhiim ugu ah fidinta leukemia-ka myelogenous (CML).Si gaar ah u gaar ah BCR-ABL, enzyme-ka la xidhiidha leukemia-da 'myelogenous leukemia' (CML) iyo noocyo gaar ah oo leukemia ba'an ah (ALL).Waa v-Abl tyrosine kinase inhibitor ah oo awood leh oo door ah (IC50 = 38 nM).Dhacdo tarjumaad ah oo u dhaxaysa koromosoomyada 9 iyo 22 waxay soo saartaa koromosoomyada Philadelphia, ka dibna waxay soo saartaa borotiinka fusion Bcr-Able leh firfircoonida kinase aberrant taasoo kor u qaadaysa kororka unugyada degdega ah.Imatinib mesylate waxay xirtaa kinase-kan muhiimka ah, joojinta korriinka CML ee la xiriira.Imatinib mesylate ayaa sidoo kale la soo bandhigay si loo joojiyo PDGFR iyo tyrosine kinases ee la xidhiidha c-Kit.
![4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Dhexdhexaad Sare daahirnimo](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)