Irbesartan CAS 138402-11-6 Nadiifnimo>99.0% (HPLC) API Warshada Kahortaga Dhiigkarka
Soo-saarka wax-soo-saarka, Nadiifinta Sare, Wax-soo-saarka Ganacsiga
| Magaca Kiimikada | Irbesartan |
| La mid ah | BMS-186295;SR-47436;Aprovel;Avapro;2-Butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4] aan-1-en- 4-hal;2-Butyl-3-[[4-[2- (2H-tetrazol-5-yl) phenyl] phenyl] methyl] -1,3-diazaspiro [4.4] aan-1-en-4-hal |
| Lambarka CAS | 138402-11-6 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C25H28N6O |
| Miisaanka Molecular | 428.54 |
| Cufnaanta | 1.30±0.10 g/cm3 |
| Ku milmay biyaha | Aan ku milmin Biyaha |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Sifada | Budada Crystalline-ka ah ee cad ama ka-baxsan, In yar ku milmi khamriga iyo chloride methylene, oo aan biyo lagu milmi karin |
| Nuugista Infrared Aqoonsiga | Baaxadda IR waxay waafaqsan tahay spectrum-ka laga helay Irbesartan RS |
| Aqoonsiga 2 | Waqtiga haynta ee chromatogram-ka ugu sarreeya ee baaritaanka ayaa u dhigma Irbesartan RS |
| Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) |
| Biyo | <0.50% |
| Biraha culus | <0.002% |
| Hadhaaga dabka | <0.10% |
| Walxaha laxidhiidha | (Waxaa qoray HPLC) |
| USP Impurity A | <0.20% |
| Xumaan kasta oo aan la aqoonsan | <0.10% |
| Wadarta wasakhda | <0.50% |
| Waxyeellada Dabiiciga ah | Buuxiyay shuruudaha USP |
| Haraaga Azide | <10pm |
| Xalalka Haraaga ah | (Waxaa qoray GC) |
| Ethanol | <5000pm |
| Toluene | <890ppm |
| Dichloromethane | <3000pm |
| N, N-Dimethylformamide | <880ppm |
| T-Butyl Methyl Ether | <5000pm |
| Qiimayn | 98.0 ~ 102.0% (waxaa lagu xisaabiyaa ku salaysan anhydrous) |
| Heerka Imtixaanka | Heerka Ganacsiga;Heerka USP |
| Isticmaalka | API;Antihypertensive;Daawaynta dhiigkarka |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
Irbesartan (CAS: C) waa angiotensin II reseptor antagonist loo isticmaalo inta badan daaweynta dhiig-karka.Irbesartan waxaa sameeyay Sanofi Research (hadda qayb ka ah Sanofi-Aventis).Waxa si wada jir ah u suuq geeyey Sanofi-Aventis iyo Bristol-Myers Squibb oo hoos yimaada magacyada ganacsiga Aprovel, Karvea, iyo Avapro.Irbesartan waxaa loo isticmaalaa in lagu daweeyo dhiig karka.Avapro waxaa laga bilaabay Germany, UK iyo US dhiig-karka.Sida dhammaan angiotensin II reseptors antagonists, irbesartan waxaa loogu talagalay daawaynta hypertension.Irbesartan waxa kale oo laga yaabaa inay dib u dhigto horumarka nephropathy macaanka waxaana sidoo kale lagu tilmaamaa dhimista horumarka cudurka kelyaha ee bukaanka qaba nooca 2aad ee sonkorowga, hypertension iyo microalbuminuria (> 30 mg / 24 saacadood) ama proteinuria.Irbesartan waxay sidoo kale yareyn kartaa dib u habeynta korantada ee myocardium, sidaas darteed waxay yareysaa heerka dhimashada bukaanada qaba hypertension, waa daawada ugu waxtarka badan ee daaweynta hypertension iyo cudurada wadnaha.
