Irinotecan Hydrochloride CAS 100286-90-6 Nadiifinta ≥99.0% (HPLC) API USP Nadiifnimada Sare
Soo saaraha soo saaraha Irinotecan iyo Dhexdhexaadiyayaasha la xidhiidha:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Saldhigga Bilaashka ah CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Magaca Kiimikada | Irinotecan Hydrochloride |
| La mid ah | Camptothecin II;CPT-II |
| Lambarka CAS | 100286-90-6 |
| Lambarka CAT | RF-API50 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C33H39ClN4O6 |
| Miisaanka Molecular | 623.15 |
| Meesha dhalaalaysa | 250-256 ℃ (dac.) |
| Xaaladaha Kaydinta | Heerkulka deegaanka hoostiisa |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada cad ama Off-Cad |
| Solubility | Ku milmay biyaha iyo methanol, wax yar ku milmay chloroform, ethanol |
| Aqoonsiga IR | Noocyada nuugista infrared-ka ee muunadda tijaabada waa inay la socotaa heerka tixraaca |
| Aqoonsiga HPLC | Waqtiga haynta ee ugu sarreysa xalka muunadda waa inuu u dhigmaa heerka tixraaca. |
| Aqoonsiga | Buuxiyay shuruudaha imtixaanada falcelinta togan ee Chloride |
| Qoyaanka (KF) | 7.0% ~ 9.0% w/w |
| Hadhaaga dabka | ≤0.10% |
| Biraha culus | ≤20pm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| Isku dhafka la xidhiidha Irinotecan A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Isku dhafka la xidhiidha Irinotecan B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Najaasad kasta oo aan la cayimin | ≤0.10% |
| Wadarta wasakhda | ≤0.50% |
| Xalalka Hadhaaga ah (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500pm |
| Peteoleum Ether: | ≤100pm |
| Ethyl acetate | ≤2000ppm |
| Benzene | ≤2pm |
| Bakteeriyada Endotoxins | ≤0.29 EU/mg Irinotecan |
| Xadka Microbial | Wadarta tirada Microbial Aerobic: <1000 cfu/g |
| Caaryada iyo khamiirka | <100 cfu/g |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC, ku salaysan anhydrous) |
| Heerka Imtixaanka | USPharmacopeia (USP) Heerka |
| Isticmaalka | Walaxda Farmashiyeedka Firfircoon (API) |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
lrinotecan hydrochloride (CAS 100286-90-6), oo ah semi-synthetic, biyo milmay oo ka mid ah wakiilka ka hortagga kansarka ee xooggan camptothecin, ayaa laga bilaabay Japan daaweynta kansarka sambabada, ugxan-sidaha, iyo ilmo-galeenka.lrinotecan waxay ku shaqeysaa firfircoonideeda antitumor iyada oo la joojinayo topoisomerase I, enzym unug ah oo ku lug leh ilaalinta qaab-dhismeedka muuqaalka DNA-da inta lagu jiro habka tarjumaada, qoraalka, iyo mitosis.lrinotecan waxa uu maraa de-esterification in vivo si uu u keeno metabolite firfircoon, SN-38, kaas oo 1000-laab ka awood badan waalidka.Daawaynta isku dhafka ah ee irinotecan oo leh walax kale oo si weyn loo isticmaalo ka hortagga kansarka, cisplatin, ayaa la sheegay in ay ka sarreyso midkood wakiilka keligiis.lrinotecan wuxuu ku jiraa tijaabooyin caafimaad oo loogu talagalay caloosha, naasaha, maqaarka, midabka midabka, kansarka ganaca, mesothelioma iyo lymphoma non-Hodgkin.
