Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Nadaafadda Sare ee Warshada
Soo saaraha soo saaraha Irinotecan iyo Dhexdhexaadiyayaasha la xidhiidha:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Saldhigga Bilaashka ah CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Magaca Kiimikada | Irinotecan Hydrochloride Trihydrate |
| La mid ah | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Lambarka CAS | 136572-09-3 |
| Lambarka CAT | RF-API52 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C33H38N4O6·HCl·3H2O |
| Miisaanka Molecular | 677.20 |
| Meesha dhalaalaysa | 250.0 ~ 256.0 ℃ (dac.) |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Jaallaha ah ama Jaallaha ah ee Crystalline |
| Qiimayn (w/w) | 98.0% ~ 102.0% |
| Daahirnimada (HPLC) | ≥99.5% |
| Solubility | In yar ku milmay biyaha, ethanol ama chloroform, oo aan si ficil ah ugu milmin acetone |
| Aqoonsiga | by IR iyo HPLC, waafaqsan |
| Wareegga indhaha ee gaarka ah | +60°~+73° |
| Biyo | 7.0% ~ 9.0% |
| Haraaga dareeraha | U hogaansama shuruudaha ICH |
| Hadhaaga dabka | ≤0.20% |
| Chloride | 5.0% ~ 6.0% |
| Qiimaha pH | 3.0 ~ 5.0 |
| Biraha culus | ≤20pm |
| Waxyeelooyinka Shaqsiga ah | ≤0.10% |
| Wadarta wasakhda | ≤0.50% |
| Xaalada Kaydinta | Ku kaydi heerkulka 2-8 ° C, weelasha xiran kana ilaali iftiinka iyo qoyaanka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Walaxda Farmashiyeedka Firfircoon (API) |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa saaraha iyo soo saaraha ugu horreeya ee Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) oo leh tayo sare leh.
Irinotecan Hydrochloride Trihydrate waa topoisomerase I inhibitor inta badan loo isticmaalo in lagu daweeyo kansarka mindhicirka iyo kansarka malawadka, ka hortagga diinta ee strand DNA iyada oo ku xidhan topoisomerase I-DNA complex.lrinotecan hydrochloride, qayb-synthetic ah, ka soosaar biyo-milmi leh oo ka mid ah wakiilka ka hortagga kansarka ee xooggan camptothecin, ayaa laga bilaabay Japan si loogu daaweeyo kansarka sambabada, ugxan-sidaha, iyo ilmo-galeenka.lrinotecan waxay ku shaqeysaa firfircoonideeda antitumor iyada oo la joojinayo topoisomerase I, enzym unug ah oo ku lug leh ilaalinta qaab-dhismeedka muuqaalka DNA-da inta lagu jiro habka tarjumaada, qoraalka, iyo mitosis.lrinotecan waxa uu maraa de-esterification in vivo si uu u keeno metabolite firfircoon, SN-38, kaas oo 1000-laab ka awood badan waalidka.Inkasta oo ay aad uga yar tahay sunta kaamtoothecin, tiro badan oo bukaanno ah oo ku jiray tijaabooyinka bukaan-socodka waxay muujiyeen waxyeellooyin ka yimaada leukopenia, shuban, lallabbo, iyo alopecia.Daawaynta isku dhafka ah ee irinotecan oo leh walax kale oo si weyn loo isticmaalo ka hortagga kansarka, cisplatin, ayaa la sheegay in ay ka sarreyso midkood wakiilka keligiis.lrinotecan wuxuu ku jiraa tijaabooyin caafimaad oo loogu talagalay caloosha, naasaha, maqaarka, midabka midabka, kansarka ganaca, mesothelioma iyo lymphoma non-Hodgkin.
