Ivabradine Hydrochloride CAS 148849-67-6 daahirnimo>99.5% (HPLC) Warshada API
Qalabka Kiimikada ee Ruifu Ivabradine Hydrochloride Dhexdhexaadiya oo leh daahir sare
Ivabradine Hydrochloride CAS 148849-67-6
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Magaca Kiimikada | Ivabradine Hydrochloride |
La mid ah | Ivabradine HCl |
Lambarka CAS | 148849-67-6 |
Lambarka CAT | RF-PI1812 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C27H36N2O5·HCl |
Miisaanka Molecular | 505.05 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Aqoonsiga | HPLC/UV waa waafaqsan yahay |
Daahirnimada / Habka Falanqaynta | >99.5% |
Khasaare xagga qalajinta | <1.00% (ku qalaji 105 ℃ hawo koronto ku qalajisa ilaa miisaan joogto ah) |
Nuxurka qoyaanka | <1.00% |
Hadhaaga dabka | <0.20% |
Ugu badnaan Single Impurity | <0.50% |
Wadarta wasakhda | <0.50% |
Isomer indhaha | <0.50% |
Qiimayn | >99.5% |
Biraha culus | <20ppm |
Wareeg gaar ah | +6.5° ~ +8.5° (oo ku salaysan qalalan, 1% xal DMSO ah) |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | API |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
Ivabradine Hydrochloride (CAS: 148849-67-6),Dadaalka lagu horumarinayo wakiilada angina iyada oo aan loo baahnayn saameyn aan loo baahnayn inotropic iyo hypotensive oo la xidhiidha xannibaadaha b-adrenergic iyo kanaalka kaalshiyamka kaalshiyamka, fasal cusub oo heerka garaaca wadnaha ee yareynaya xeryahooda kuwaas oo si gaar ah ugu dhaqma qanjidhada sinoatrial (SA) ayaa la sahamiyay.Wakiiladan bradycardic waxay si toos ah ula falgalaan unugga xawaare samaynta ee noode SA iyo hyperpolarization-ka-shaqeeya Haddi xawaaraha degdega ah ee aasaasiga ah.Ivabradine waxay u xuubsiibtay xannibaadaha gaarka ah ee Haddii hadda jira iyada oo la xidhiidhka f-channels ee dhinaca intracellular ee xuubka plasma.Natiijo ahaan, Ivabradine waxay yaraynaysaa xawaaraha diastolic depolarization waxayna hoos u dhigtaa garaaca wadnaha.Waxaa loo oggolaaday daawaynta angina deggan oo daba-dheeraatay waxayna siisaa beddel macquul ah oo bukaannada leh iska-hor-imaad ama dulqaad-darro-blockers.Qiimaynta ayaa sidoo kale socota daaweynta suurtagalka ah ee cudurka wadnaha ischaemic.