L-4-Nitrophenylalanine Methyl Ester HCl CAS 17193-40-7 H-Phe(4-NO2)-OMe·HCl Assay>98.5% (HPLC) Warshada
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha iyo soo saaraha ugu horreeya ee L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe (4-NO2) - OMe · HCl (CAS: 17193-40-7) oo leh tayo sare leh.Kiimikada Ruifu waxay keentaa asiidhyo amino oo taxane ah iyo soosaarayaal.Waxaan bixin karnaa gaarsiinta adduunka oo dhan, tiro yar iyo tiro badan oo la heli karo.Haddii aad u baahan tahay L-4-Nitrophenylalanine Methyl Ester HCl,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | L-4-Nitrophenylalanine Methyl Ester HCl |
| La mid ah | H-Phe(4-NO2)-OMe·HCl;Hp-Nitro-Phe-OMe·HCl;L-Phe(4-NO2)-OMe·HCl;p-Nitro-L-Phe-OMe·HCl;L-4-NO2-Phe-OMe·HCl;L-4-Nitrophenylalanine Methyl Ester Hydrochloride;4-Nitro-L-Phenylalanine Methyl Ester Hydrochloride;p-Nitrophenylalanine Methyl Ester Hydrochloride;Methyl 4-Nitro-L-Phenylalaninate Hydrochloride;(S)-(+)-4-Nitrophenylalanine Methyl Ester Hydrochloride |
| Heerka Saamiyada | Kaydka dhexdiisa, Awood Wax-soo-saar 20 Tan bishii |
| Lambarka CAS | 17193-40-7 |
| Qaanuunka molecular | C10H12N2O4·HCl |
| Miisaanka Molecular | 260.67 |
| Meesha dhalaalaysa | 225.0 ~ 235.0 ℃ |
| Heerkulka Kaydinta | Lagu xidhay qalalan, ku kaydi heerkulka qolka |
| COA & MSDS | La heli karo |
| Kala soocidda | Amino Acids & Derivatives |
| Summada | Kiimikada Ruifu |
| Bayaanka Khatarta | 22-43-36 | Heerka khatarta | 6.1 |
| Bayaanada Badbaadada | 22-36/37-24/25 | Kooxda Baakadaha | III |
| RIDADR | 2811 | Koodhka HS | 2922491990 |
| WGK Germany | 3 |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Sharaxaada | Ka-caddan ilaa budada jaalaha ah ee cirro leh | waafaqsan |
| Aqoonsiga HPLC | Waqtiga haynta ee ugu sarreysa chromatogram-ka diyaarinta tijaabada waxay u dhigantaa in chromatogram-ka nidaamka ku habboonaanta nidaamka sida lagu helay nadiifnimada chromatographic iyo wasakhda ee HPLC | waafaqsan |
| Wareeg gaar ah [α]20/D | +20.0 ilaa +24.0° (C=1, MeOH) | +22.4° |
| Meesha dhalaalaysa | 225.0 ~ 235.0 ℃ | 227.0 ~ 230.0 ℃ |
| Khasaare xagga qalajinta | <0.50% ( saacada 105 ℃ ilaa 3 saacadood) | 0.23% |
| Hadhaaga dabka | <0.10% | 0.06% |
| Habka Qiimaynta / Falanqaynta | >98.5% (waxaa qoray HPLC) | 98.75% |
| Content Enantiomer | <0.15% (waxaa qoray HPLC) | 0.09% |
| 4-Nitro-L-Phenylalanine | <1.50% (waxaa qoray HPLC) | 0.91% |
| Wadarta wasakhda | <1.50% (waxaa qoray HPLC) | 1.25% |
| Gabagabo | Alaabtan iyadoo la raacayo Heshiisyada Kormeerka ee Heerarka Ganacsiga | |
| Nolosha shelf | 24 bilood Baakadeeda asalka ah haddii si sax ah loo kaydiyo | |
| Isticmaalka Muhiimka ah | Dhexdhexaadiyeyaasha Dawooyinka;Dhexdhexaadiyaha Zolmitriptan | |
Xidhmada: Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha daboolan bakhaar qabow, engegan oo hawo leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Habka Falanqaynta L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2) -OMe·HCl (CAS: 17193-40-7)
Sharaxaad: Dhig ilaa 2 g oo muunad ah saxan petri-engegan oo nadiif ah oo fiirso muuqaalka muunada.Warbixinta: Ka warbixi kormeerka
Identificaiton: Is barbar dhig wakhtiga haynta ee koromogaraamka ugu sarreeya ee chromatogram-ka diyaarinta tijaabada iyo wakhtiga haynta ee chromatogram-ka ugu weyn ee ku habboonaanta nidaamka sida lagu helay nadiifnimada chromatographic ee HPLC.
Khasaare xagga qallajinta: Ku qalaji dhalada miisaankeedu yahay 105 ± 2 ℃ 30 daqiiqo.U ogolow inuu ku qaboojiyo heerkulka qolka qalabka wax lagu nadiifiyo.Si sax ah ugu miisaan dhalada wax lagu miisaamo oo ku dheji miisaanka (W1).Ku wareeji qiyaastii 1 ilaa 2g tirada saxda ah ee walaxda tijaabada ku wareeji dhalada miisaanka.Si tartiib ah, rux dhinac dhinac ah, u qaybi muunada tijaabada si siman sida ugu macquulsan ilaa qoto dheer oo ku saabsan 5 mm.Miisaami dhalada miisaanka leh oo qor miisaanka (W2).Dhalada rartay dhig foornada qalajinta, ka saar joogsiga oo sidoo kale uga tag qolka.Ku qalaji saamiga tijaabada 105± 2℃ 3 saacadood.Markaad furto qolka, si degdeg ah u xidh dhalada, una ogolow inay ku timaado heerkulka qolka qallajiye.Si sax ah ugu miisaan dhalada wax lagu miisaamo oo ku celi miisaanka (W3).Xisaabi khasaaraha boqolleyda ee qallajinta muunadda adiga oo isticmaalaya caanaha soo socda:
Khasaaraha Xisaabinta ee qalajinta (% w/w)= (W2-W3) ÷ (W2-W1) x 100
Waxyaabaha Enantiomer ee HPLC:
Kiimikada & Reagent:
n-Hexane AR darajo
Methanol HPLC darajada
isopropyl Khamriga HPLC darajada
Diethylamine AR darajo
Heerarka: L-4-Nitrophenylalanine Methyl Ester HCl heerka;L-4-Nitrophenylalanine Methyl Ester HCl enantiomer heerka
Wajiga wareegta: Diyaari isku dhafka n-Hexane, Alcohol isopropyl, Methanol iyo Diethylamine (65:20:15:0.1 v/v/v/v)
Diyaarinta maran: Ku wareeji 2.5ml ee Methanol gudaha galaas mug leh oo 10-ml ah, ku milo mugga wejiga moobilka oo qas.
Diyaarinta ku habboonaanta nidaamka:
Si sax ah u miisaamee oo ku wareeji qiyaastii 5 mg midkiiba L-4-Nitrophenylalanine Methyl Ester HCl standard iyo L-4-Nitrophenylalanine Methyl Ester HCl enantiomer heerka 10-ml ee weelka mugga 10-ml, ku milmi qiyaastii 2.5ml oo methanol ah, ku milo mugga moobilka. wejiga iyo qas.
Diyaarinta tijaabada:
Si sax ah u miisaan oo ku wareeji qiyaastii 5 mg oo muunad ah 10-mol oo muunad ah, ku mil ilaa 2.5ml oo methanol ah, ku milo mugga wejiga wareega oo qas.
Qiyaasaha qalabka:
Qalabka: HPLC oo ku qalabaysan durduriyaha, Pump, UV detector iyo Recorder
Tiirka: ChiralPak-IC (4.6mm x 250mm) 5 μ ama u dhigma
Heerka socodka: 1.0 ml/daqiiqo
Dhererka hirarka: 260nm
Mugga mudista: 10 μL
Heerkulka tiirka: 25 ℃
Wakhtiga orodka: 20 daqiiqo
Habraaca
Duri xalalka sida lagu sheegay taxanaha soo socda.Qor chromatogram-yada oo xaqiiji shuruudaha:
Sharaxaada Tirada Duritaanada Shuruudaha Durida
Diyaarinta Banaan 1 Ma jiro ugu sarreeya ee faragelinaya wakhtiga haynta L-4-Nitrophenylalanine Methyl Ester HCl ama enantiomer.
Diyaarinta ku habboonaanta nidaamka 1 Qaraarka u dhexeeya L-4-Nitrophenylalanine Methyl Ester HCl iyo enantiomer ugu sarreeya waa inuusan ka yarayn 2.0
Diyaarinta Tijaabada 1 Isticmaal chromatogram-ka tijaabada si aad u go'aamiso waxa enantiomer ku jira muunada.
Wakhtiyada haynta qaraabada:
L-4-Nitrophenylalanine Methyl Ester HCl 1.0
Enantiomer ku saabsan 1.11
Waqtiga haynta L-4-Nitrophenylalanine Methyl Ester HCl waa qiyaastii 9.8 daqiiqo.
Xisaabinta: chromatogram-ka laga helay diyaarinta tijaabada, iska ilaali dhammaan meelaha ugu sarreeya ee laga filayo L-4-Nitrophenylalanine Methyl Ester HCl iyo Enantiomer.Ka warbixi waxa ka kooban enantiomer ee muunada iyadoo loo eegayo habka caadiga ah ee aagga.
Nadiifinta Chromatogrpahic iyo wasakhda ee HPLC:
Kiimikada & Reagenayaasha:
Diammonium phosphate AR darajo
Phosphoric acid AR
Methanol HPLC darajada
Biyo Sifaysan
Heerarka
L-4-Nitrophenylalanine Methyl Ester HCl heerka
4-Nitro-L-Phenylalanine monohydrate heerka
Wajiga Mobile-A
Ku mil 6.6 g oo ah Diammonium phosphate 1000ml oo biyo sifaysan.Ku hagaaji pH ee xalkan 6.0 oo leh Phosphoric acid.Shaandhayso iyo degas.Kahor intaadan cabbirin pH ee xalka, ku cabbir pH mitirka oo leh xalka kaydinta caadiga ah pH 4.01 IYO 7.00.
Marxaladda-B
Methanol HPLC darajada
Diyaarinta Habboonaanta Nidaamka
Si sax ah u miisaamee oo ku wareeji qiyaastii 25 mg midkiiba L-4-Nitrophenylalanine Methyl Ester HCl standard iyo 4-Nitro-L-Phenylalanine monohydrate halbeegga 50-ml ee weel mug leh, ku milmi oo ku milo mugga methanol iyo qas.
Diyaarinta Imtixaanka:
Si sax ah u miisaan oo ku wareeji muunada 25 mg ee galaas mug leh oo 50-ml ah, ku mil oo ku mil mugga methanol oo qas.
Qiyaasaha qalabka:
Qalabka: HPLC oo ku qalabaysan durduriyaha, Pump, UV detector iyo Recorder
Tiirka: Xterra RP-18 (4.6mm x 150mm) 5 μ ama wax u dhigma
Heerka socodka: 1.0 ml/daqiiqo
Dhererka hirarka: 265nm
Mugga cirbadeynta: 20 μL
Heerkulka tiirka: 25 ℃
Wakhtiga orodka: 45 daqiiqo
Barnaamijka Gradient
Waqtiga (daqiiqo) Wajiga Moobaylka-A % Wajiga Mobilka-B %
0.01 90 10
15 60 40
35 40 60
40 35 65
41 90 10
45 90 10
Habka:
Duri xalalka sida lagu sheegay taxanaha soo socda.Qor chromatogram-yada oo xaqiiji shuruudaha:
Diyaarinta maran 1 Ma jiro ugu sarreeya ee dhexgalaya waa in la eego wakhtiga haynta L-4-Nitrophenylalanine Methyl Ester HCl.
Diyaarinta ku habboonaanta nidaamka 1 Qodobka dabada ee L-4-Nitrophenylalanine Methyl Ester HCl ugu sarreysa waa inuusan ka yarayn 2.0
Diyaarinta tijaabada 1 Isticmaal chromatogram-ka tijaabada si aad u go'aamiso daahirnimada iyo wasakhowga chromatographic.
Wakhtiyada haynta qaraabada:
L-4-Nitrophenylalanine Methyl Ester HCl 1.0 (waqtiga haynta ilaa 11.4 daqiiqo)
4-Nitro-L-Phenylalanine Qiyaastii 0.4
Toluene Ku saabsan 2.3
Xisaabinta:
chromatogram-ka laga helay diyaarinta tijaabada, ka dib markii la saxo maran, iska ilaali meesha ugu sarreysa sababtoo ah toluene.Ka warbixi daahirsanaanta chromatographic, 4-Nitro-L-Phenylalanine waxa ku jira iyo wadarta wasakhda ku jirta muunada iyadoo loo eegayo habka caadiga ah ee aagga.
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L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-OMe·HCl) (CAS: 17193-40-7) waa dhex dhexaad ka ah isku dhafka daawooyinka kala duwan.L-4-Nitrophenylalanine Methyl Ester HCl waxaa loo isticmaali karaa diyaarinta Matijin-Su derivatives sida kuwa awood leh ee ka hortagga HBV.L-4-Nitrophenylalanine Methyl Ester HCl waxaa loo isticmaali karaa sidii dhexdhexaadka dawooyinka ee Zolmitriptan (CAS: 139264-17-8).Zolmitriptan waa agonist receptor serotonin oo la xushay oo ka mid ah noocyada 1B iyo 1D.Waxaa inta badan loo adeegsadaa daawaynta degdega ah ee werarada dhanjafka oo leh ama aan lahayn aura iyo madax-xanuun kooxeed.Zolmitriptan waxay saameyn ku yeelataa iyada oo loo marayo xiritaanka bini'aadamka 5-HT1Band 5-HT1Dreceptors, taasoo horseedaysa xannibaadda xididdada dhiigga ee cranial iyo sii deynta neuropeptides dareenka iyada oo loo marayo dhammaadka dareemayaasha nidaamka trigeminal.
