L-Thyroxine CAS 51-48-9 daahirnimo>98.0% (HPLC)
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Magaca Kiimikada | L-Thyroxine |
La mid ah | Levothyroxine;L-T4;NSC 36397;(-) Thyroxine;3,3',5,5'-Tetraiodo-L-Thyronine;3,5,3',5'-Tetraiodothyronine;beta-[(3,5-Diiodo-4-Hydroxyphenoxy)-3,5-Diiodophenyl] alanine;β-((3,5-Diiodo-4-Hydroxyphenoxy) -3,5-Diiodophenyl) alanine;o-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosine |
Lambarka CAS | 51-48-9 |
Lambarka CAT | RF2891 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C15H11I4NO4 |
Miisaanka Molecular | 776.87 |
Meesha dhalaalaysa | 227.0 ~ 230.0 ℃ |
Barta Karsan | 576.3 ± 50.0 ℃ |
Cufnaanta | 2.635 |
Xasaasi ah | Iftiinka xasaasiga ah |
Biyuhu milmayn | Aan ku milmin Biyaha |
Solubility | Ku milma 4M Ammonium Hydroxide ee Methanol at 50mg/ml |
Xasilooni | ≥ 2 Sano |
Koodhka HS | 29379000 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Caddaan ama Banaan-cad budada Crystalline |
Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) |
Meesha dhalaalaysa | 227.0 ~ 230.0 ℃ |
Wareeg gaar ah [α]20/D | -5.2°~ -6.2° (C=1, Ethanol: 1N NaOH=2:1) |
Biraha culus (Pb) | ≤10pm |
Khasaare xagga qalajinta | <0.20% |
Hadhaaga dabka | <0.10% |
Wadarta wasakhda | <1.50% |
Infrared Spectrum | Waafaqsan Qaab-dhismeedka |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyeyaasha Daawooyinka |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
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L-Thyroxine (CAS: 51-48-9) ama Levothyroxine waa hoormoonka tayroodhka synthetic kaas oo kiimiko ahaan la mid ah thyroxine (T4), kaas oo si dabiici ah u qarsoon unugyada follicular ee qanjidhada thyroid.Waxaa loo isticmaalaa in lagu daweeyo yaraanta hoormoonka tayroodh, iyo marmar si looga hortago soo noqoshada kansarka tayroodh.Sida dhiggeeda sirta ah ee dabiiciga ah, Levothyroxine waa unug ka samaysan qaab-dhismeedka L-qaabka.Daawada la xidhiidha dextrothyroxine (D-Thyroxine) ayaa loo isticmaali jiray waagii hore sida daawaynta hypercholesterolemia (heerarka kolestaroolka sare) laakiin waa laga saaray sababo la xiriira saameynaha wadnaha.L-Thyroxine waxaa inta badan loo isticmaalaa daawaynta hypothyroidism, goiter, lymphocytic thyroiditis chronic, myxedema kooma, iyo miyir beelka.In vivo, L-Thyroxine (0.9 iyo 2.7 μg) waxay joojisaa isku-darka iyo sii-deynta thyrotropin ee ay keento hoormoonka sii daaya thyrotropin ee pituitary hore ee jiirarka.Daawooyinka ka kooban L-Thyroxine ayaa loo isticmaalay daawaynta hypothyroidism.Daaweynta Levothyroxine waxaa loo isticmaalaa haddii ay dhacdo yaraanta hormoonnada tayroodhka ee jidhka bini'aadamka, sababtoo ah waxay ku dhacdaa yaraanta qanjidhada thyroid, pituitary iyo hypothalamic (sida asaasiga ah, sare iyo sare ee hypothyroidism).L-Thyroxine sidoo kale waxaa loo isticmaalaa daaweynta goiter euthyroid iyo goiter multinodular, oo ay ku jiraan qanjirka thyroid nodules, subacute ama thyroiditis chronic, ama kiiska qalliin ka dib, ama ka dib daaweynta radiometabolic bukaanka qaba kansarka thyroid.Saamaynta dawadani waxay si weyn ugu xidhan tahay qiyaasta.Qiyaaso yaryar, L-Thyroxine waxay soo bandhigtaa ficil anabolic ah.Qiyaasta dhexdhexaadka ah, waxay kicisaa koritaanka iyo horumarinta unugyada, dheef-shiid kiimikaadka borotiinka, dufanka, iyo karbohaydraytyada, waxay kordhisaa dhaqdhaqaaqa shaqada ee habdhiska dhexe ee neerfaha iyo wadnaha, iyo sidoo kale kelyaha iyo beerka.Qiyaaso badan, waxay hoos u dhigtaa dhaqdhaqaaqa thyroid-ka ee hypophysis waxayna hoos u dhigtaa wax soo saarka qanjidhada thyroid.