Lasofoxifene Tartrate CAS 190791-29-8 Daahirnimada Chiral ≥99.0% Daahirnimada
Soo saaraha soo saaraha oo leh nadiif sare iyo tayo xasilan
Magaca Kiimikada: Lasofoxifene Tartrate
CAS: 190791-29-8
Lasofoxifene Tartrate (CAS: 190791-29-8) ee daawaynta lafo-beelka postmenopausal
Magaca Kiimikada | Lasofoxifene Tartrate |
La mid ah | (5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol Tartrate Oporia |
Lambarka CAS | 190791-29-8 |
Lambarka CAT | RF-API20 |
Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
Qaanuunka molecular | C28H31NO2.ClH |
Miisaanka Molecular | 450.019 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Caddaan ilaa budo cad-cad |
Qoyaanka (KF) | ≤0.50% |
Biraha culus | ≤20pm |
Daahirnimada Chiral | ≥99.0% |
Daahirnimada / Habka Falanqaynta | ≥98.0% (HPLC) |
Khasaare xagga qalajinta | ≤0.50% |
Hadhaaga dabka | ≤0.50% |
Heerka Imtixaanka | Farmashiyaha Shiinaha (CP);Heerka Ganacsiga |
Isticmaalka | Walaxda Farmashiyeed ee Firfircoon (API);Lafo-jileecu ka dib |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa hormuudka soo saaraha iyo alaab-qeybiyaha Lasofoxifene Tartrate (CAS: 190791-29-8) oo leh tayo sare.
Lasofoxifene Tartrate waa jiilka saddexaad, modulator-ka soo-dhoweynta estrogen-ka ee aan isteeroyda ahayn (SERM).Waxay si xushmad leh ugu xidhaa ERalpha bini'aadamka oo leh qiime IC50 ah 1.5 nM waxayna ka hortagtaa luminta lafaha jiirka ugxan-sidaha.Daraasadaha kiliinikada ee osteoporosis postmenopausal, 0.5 mg / maalin lasofoxifene ayaa lala xiriiriyay khataraha yaraaday ee jabka aan vertebral iyo vertebral, kansarka naasaha ER-positive, cudurada wadnaha wadnaha, iyo istaroogga laakiin khatarta sii kordheysa ee dhacdooyinka thromboembolic venous.Lasofoxifene ayaa sidoo kale lagu muujiyay inuu u dhaqmo sidii agonist-ka soo horjeeda ee CB2 cannabinoid reseptor, taasoo muujinaysa awooddeeda in dib loo soo celiyo sida daaweynta calaamadaha CB2 waa bartilmaameed.