LCZ696 Dhexdhexaad CAS 1426129-50-1 Nadiifinta ≥98.0% (HPLC) ee
Sahayda Ganacsiga LCZ696 (CAS: 936623-90-4) Dhexdhexaadinta la xidhiidha:
(R) -tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl) carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium cusbo) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Isku darka Sacubitril ee Valsartan CAS: 936623-90-4
| Magaca Kiimikada | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl) carbamate |
| La mid ah | Dhexdhexaad LCZ696 |
| Lambarka CAS | 1426129-50-1 |
| Lambarka CAT | RF-PI169 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C20H25NO3 |
| Miisaanka Molecular | 327.42 |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ilaa budo cad-cad |
| Daahirnimada / Habka Falanqaynta | ≥98.0% (HPLC) |
| Xad-dhaafka Enantiomeric | ee: ≥99.0% |
| Qoyaanka (KF) | ≤1.0% |
| Walxaha laxidhiidha A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Walxaha laxidhiidha B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Walxaha kale | ≤1.0% |
| Wadarta wasakhda | ≤2.0% |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyaha LCZ696 (CAS: 936623-90-4) ee daawaynta HFrEF |
Xidhmada: Dhalo, boorsada bireed aluminium, durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Soo-saare leh Nadiif Sarreysa iyo Tayo Deggan
Sahayda Ganacsiga LCZ696 (CAS: 936623-90-4) Dhexdhexaadinta la xidhiidha:
(R) -tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl) carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium cusbo) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Isku darka Sacubitril ee Valsartan CAS: 936623-90-4
LCZ696 waa daawo tijaabo ah oo ay samaysay Novartis Pharmaceutical ee Maraykanka si loogu daweeyo bukaanada qaba Wadnaha Wadnaha oo leh jajabka Ejection ee la dhimay (HFrEF).Wadnaha oo istaaga waa cudur nafta halis gelisa.Wadnaha bukaanku ma shubi karo dhiig ku filan si uu jidhka u siiyo, oo ay u muuqdaan calaamadaha dyspnea, daalka iyo dheecaanka joogitaanka si tartiib ah, ka dibna si tartiib tartiib ah u kordhay, si weyn u saameeya tayada nolosha.LCZ696 waxay kor u qaadi kartaa difaaca dabiiciga ah ee jirka ee ka hortagga wadnaha wadnaha, iyo sidoo kale kordhinta heerka peptides natriuretic iyo peptides kale oo loo yaqaan 'vasoactive peptides', waxayna joojinayaan nidaamka renin-angiotensin-aldosterone (RAAS).LCZ696 ayaa lagu daray Novartis's Hypertension Medicine (Diovan, magaca guud: valsartan) iyo daawada tijaabada ah AHU-377.AHU377 waxay xannibaysaa habka labada peptides ee ka masuulka ah hoos u dhigista cadaadiska dhiigga.Diovan waxay hagaajisaa vasodilatation waxayna kicisaa jirka si uu u soo saaro sodium iyo biyaha.
