Lenvatinib Mesylate Intermediate CAS 205448-65-3 daahirnimo>98.0% (HPLC) Warshada
Qalabka Kiimikada ee Ruifu Lenvatinib Mesylate Dhexdhexaadiyeyaasha oo leh nadiif sare
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Magaca Kiimikada | Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate |
La mid ah | 1,4-Dihydro-7-Methoxy-4-Oxo-6-Quinolinecarboxylic Acid Methyl Ester;7-Methoxy-4-Oxo-1,4-Dihydro-Quinoline-6-Carboxylic Acid Methyl Ester;Dhexdhexaadiyaha Lenvatinib 3 |
Lambarka CAS | 205448-65-3 |
Lambarka CAT | RF-PI1973 |
Heerka Saamiyada | Kaydka dhexdiisa, Awoodda Wax-soo-saarka 50 MT/Sannadka |
Qaanuunka molecular | C12H11NO4 |
Miisaanka Molecular | 233.22 |
Barta Karsan | 421.0 ± 45.0 ℃ |
Cufnaanta | 1.267 ± 0.060 g / cm3 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Ka-bax-cad ilaa budada jaalaha ah |
Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) |
Khasaare xagga qalajinta | <1.00% |
Hadhaaga dabka | <0.50% |
Wadarta wasakhda | <2.00% |
H-NMR | Waafaqsan Qaab-dhismeedka |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyeyaasha Daawooyinka |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate (CAS: 205448-65-3) waa dhexe ee Lenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib, oo lagu iibiyo magaca astaanta Lenvima iyo kuwa kale, waa dawo ka hortagga kansarka oo loogu talagalay daawaynta noocyada kansarka tayroodhka qaarkood iyo kansarrada kale sidoo kale.Waxaa soo saaray Eisai Co. waxayna u shaqeysaa sidii dhowr kinase inhibitor lid ku ah VEGFR1, VEGFR2 iyo VEGFR3 kinases.Lenvatinib waxaa loo oggolaaday (ilaa 2015) daaweynta kansarka qanjirka tayroodh ee kala duwan kaas oo ah mid gudaha ku soo noqnoqda ama metastatic, horumarsan, oo aan ka jawaabin daaweynta iodine radioactive (radioiodine).Bishii Maajo 2016, Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) ayaa ansixiyay (oo ay weheliso everolimus) daaweynta kansarka unugyada kelyaha ee horumarsan ka dib hal daawaynta kahortagga angiogenic.Daawadu waxa kale oo laga oggolaaday Maraykanka iyo Midowga Yurub kansarka hepatocellular kansarka aan laga saari karin qaliinka bukaanada aan helin daawaynta kansarka afka ama duritaanka.