Lesinurad (RDEA 594) CAS 878672-00-5 daahirnimo>99.5% (HPLC) Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Lesinurad (RDEA 594) (CAS: 878672-00-5) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibka Lesinurad iyo Dhexdhexaadiyeyaasha,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Lesinurad |
| La mid ah | 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio] acetic acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 878672-00-5 |
| Qaanuunka molecular | C17H14BrN3O2S |
| Miisaanka Molecular | 404.28 g/mol |
| Meesha dhalaalaysa | > 171 ℃ (dac.) |
| Cufnaanta | 1.72±0.10 g/cm3 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Caddaan ilaa budo cad-cad | Budo-cad-cad |
| Aqoonsiga | Waqtiga haynta ee ugu sarreeya ee xalka muunadda ayaa u dhigma heerka tixraaca | U hogaansama |
| Biyaha waxaa qoray Karl Fischer | <0.50% | 0.14% |
| Hadhaaga dabka | <0.10% | 0.03% |
| Biraha culus (Pb) | ≤10pm | <10pm |
| Walxaha La Xiriira (HPLC) | ||
| Nijaasta keliya ee ugu weyn | <0.20% | 0.07% |
| Wadarta wasakhda | <1.00% | 0.24% |
| Daahirnimada / Habka Falanqaynta | >99.5% (HPLC Aagga) | 99.76% |
| Qiimayn | 98.0 ~ 102.0% | 99.6% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
Suuqyada Waaweyn?Iibiya suuqa gudaha, Waqooyiga Ameerika, Yurub, Hindiya, Kuuriya, Jabbaan, Australia, iwm.
Faa'iidooyinka?Tayada sare, qiimo jaban, adeegyo xirfadeed iyo taageero farsamo, gaarsiin degdeg ah.
TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.
Tusaalooyinka?Badeecadaha intooda badani waxay bixiyaan muunado bilaash ah oo loogu talagalay qiimeynta tayada, kharashka dhoofinta waa in ay bixiyaan macaamiisha.
Hantidhawrka Warshada?Hantidhawrka warshada soo dhawoow.Fadlan horay u sii ballan.
MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.
Gaadiidka?By Express (FedEx, DHL), hawada, badda.
Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
Isku-dhafka gaarka ah?Waxay ku siin kartaa adeegyada isku-dhafka gaarka ah si ay ugu habboonaato baahiyahaaga cilmi-baarista.
Shuruudaha Lacag-bixinta?Qaansheegga Proforma ayaa marka hore la soo diri doonaa ka dib marka la xaqiijiyo dalabka, oo lagu soo lifaaqay macluumaadka bangigayaga.Lacag bixinta T/T (Telex Transfer), PayPal, Western Union, iwm.
Lesinurad (RDEA 594) (CAS: 878672-00-5) waxaa ansixiyay Maamulka Cuntada iyo Dawooyinka ee Maraykanka (FDA) December 22, 2015, ka dibna waxaa ansixiyay Wakaaladda Daawooyinka Yurub (EMA) Febraayo 18, 2016. xarun hore waxaa hormariyay Ardea.AstraZeneca waxay heshay shirkadda 2012, taas oo iyaduna heshay alaabta.Magaca ganacsiga daroogada waa Zurampic® gudaha Mareykanka iyo Midowga Yurub.Lesinurad waa xakameyihii urate reuptake transporter (URAT1) ee aduunka ugu horeeyay ee la ansixiyay, oo lagu daray xanthine oxidase inhibitors si loo daaweeyo gout hyperuricemia la xiriirta.
Lesinurad, magaca ganacsiga Zurampic.Lesinurad oo ay weheliso xanthine oxidase inhibitor (XOI) oo loogu talagalay cudurka gout hyperuricemia.Nidaamkeeda ficilku waa inay ka caawiso kelyaha inay soo saaraan uric acid, waxayna u shaqeysaa iyadoo la joojinayo shaqada gaadiidleyda ee ku lug leh dib u nuugista uric acid ee kelyaha.
Lesinurad waxay joojisaa dhaqdhaqaaqa gaadiidka uric acid (IC50=3.36 μM) ee hURAT1 (URAT1 aadanaha), taas oo ka badan 20 jeer saameynta xannibaadda ee RURAT1 (rat URAT1) (IC50=74.84 μM).Lesinurad waxay joojisaa hURAT1 iyada oo loo marayo isdhexgalka muhiimka ah ee hadhaaga amino acid Phe365.
