Letrozole CAS 112809-51-5 API Warshada Aromatase Inhibitor II Tayada Sare
U keeni Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: Letrozole
CAS: 112809-51-5
Aromatase Inhibitor II
API Tayada Sare, Wax soo saarka Ganacsiga
Magaca Kiimikada | Letrozole |
La mid ah | CGS-20267;Femara |
Lambarka CAS | 112809-51-5 |
Lambarka CAT | RF-API86 |
Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
Qaanuunka molecular | C17H11N5 |
Miisaanka Molecular | 285.3 |
Meesha dhalaalaysa | 181.0 ilaa 183.0 ℃ |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Solubility | Si Xor Ah Ugu milmi kara Dichloromethane, In yar oo Ethanol ku milmi kara |
Aqoonsiga IR | Spectrum muunadu waxay u dhigantaa heerka tixraaca |
Aqoonsiga HPLC | Waqtiga haynta ee muunadda imtixaanku waxay u dhigantaa heerka tixraaca |
Waxyaalaha biyaha (waxaa qoray KF) | ≤0.30% |
Hadhaaga dabka | ≤0.10% |
Walxaha laxidhiidha | |
Walxaha laxidhiidha A | ≤0.30% |
Walxaha laxidhiidha B | ≤0.20% |
Najaasad kasta oo aan la cayimin | ≤0.10% |
Wadarta wasakhda aan la cayimin | ≤0.30% |
Wadarta wasakhda | ≤0.50% |
Xalalka Haraaga ah | |
Ethyl acetate | ≤0.50% |
Methanol | ≤0.30% |
Ethanol | ≤0.50% |
DMF | ≤0.088% |
Biraha culus | ≤10pm |
Qiimayn | 98.0% ~ 102.0% (oo ku saleysan anhydrous) |
Nolosha shelf | 24 bilood |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | API, Aromatase Inhibitor II |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
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Letrozole (CAS 112809-51-5) waa qayb ka mid ah jiilka cusub ee xakameynaya aromatase ee aadka loo xushay waana derivative benzotriazole si macmal ah loo sameeyay.Letrozole waxay xakameysaa aromatase si ay hoos ugu dhigto heerarka estrogen, sidaas awgeed waxay ka hortagtaa estrogen ka soo kicinta koritaanka burada.Dhaqdhaqaaqeeda in vivo waa 150-250 jeer ka xoog badan kan jiilka kowaad aromatase inhibitor Amarante.Maaddaama ay aad u doorato, ma saameyn doonto glucocorticoid, mineralocorticoid iyo hawlaha thyroid;xitaa marka la qaato qiyaasta sare, ma yeelan doonto wax saameyn ah oo ka hortag ah oo ku saabsan dheecaanka corticosteroid adrenal, taas oo siinaysa tusaha daaweynta sare.Letrozole ma laha suntan qarsoon oo ku wajahan nidaam kasta oo jirka ah iyo xubnaha bartilmaameedka ah, ma laha mutagenicity iyo saamaynta kansarka, waxay leedahay saameynaha ugu yar ee sunta ah, si fiican ayaa loo dulqaadanayaa, waxayna leedahay saameyn liddi ku ah kansarka marka loo eego kuwa kale ee aromatase inhibitors iyo daawooyinka antiestrogen.Letrozole waxay ku habboon tahay kansarka naasaha ee hore u maray bukaannada postmenopausal ee aan ka jawaabin daaweynta estrogen-xakamaynta iyo daaweynta kansarka naasaha ee hore.Waxaa loo isticmaalaa in lagu daweeyo bukaanada postmenopausal ee qaba kansarka naasaha ee sareeya waxayna u adeegtaa sidii daawaynta safka labaad si loo raaco daawaynta antiestrogen-ka ee aan guulaysan.