Letrozole CAS 112809-51-5 API Warshada Aromatase Inhibitor II Tayada Sare

Letrozole (CAS 112809-51-5) waa qayb ka mid ah jiilka cusub ee xakameynaya aromatase ee aadka loo xushay waana derivative benzotriazole si macmal ah loo sameeyay.Letrozole waxay xakameysaa aromatase si ay hoos ugu dhigto heerarka estrogen, sidaas awgeed waxay ka hortagtaa estrogen ka soo kicinta koritaanka burada.Dhaqdhaqaaqeeda in vivo waa 150-250 jeer ka xoog badan kan jiilka kowaad aromatase inhibitor Amarante.Maaddaama ay aad u doorato, ma saameyn doonto glucocorticoid, mineralocorticoid iyo hawlaha thyroid;xitaa marka la qaato qiyaasta sare, ma yeelan doonto wax saameyn ah oo ka hortag ah oo ku saabsan dheecaanka corticosteroid adrenal, taas oo siinaysa tusaha daaweynta sare.Letrozole ma laha suntan qarsoon oo ku wajahan nidaam kasta oo jirka ah iyo xubnaha bartilmaameedka ah, ma laha mutagenicity iyo saamaynta kansarka, waxay leedahay saameynaha ugu yar ee sunta ah, si fiican ayaa loo dulqaadanayaa, waxayna leedahay saameyn liddi ku ah kansarka marka loo eego kuwa kale ee aromatase inhibitors iyo daawooyinka antiestrogen.Letrozole waxay ku habboon tahay kansarka naasaha ee hore u maray bukaannada postmenopausal ee aan ka jawaabin daaweynta estrogen-xakamaynta iyo daaweynta kansarka naasaha ee hore.Waxaa loo isticmaalaa in lagu daweeyo bukaanada postmenopausal ee qaba kansarka naasaha ee sareeya waxayna u adeegtaa sidii daawaynta safka labaad si loo raaco daawaynta antiestrogen-ka ee aan guulaysan.