Lopinavir CAS 192725-17-0 API Ka-hortagga ka-hortagga HIV-ga ee ka hortagga HIV-ga COVID-19 Nadiif Sare

Lopinavir (ABT-378) waa mid aad u awood badan, xakameynaya peptidomimetic peptidomimetic ee borotiinka HIV-1, oo leh Kis of 1.3 ilaa 3.6 pM ee nooca duurjoogta ah iyo borotiinka HIV-ga beddelka ah.Lopinavir waxay u shaqeysaa iyadoo xiraysa qaangaarnimada HIV-1 si ay u xannibto faafitaankeeda.Lopinavir sidoo kale waa SARS-CoV 3CLpro inhibitor oo leh IC50 oo ah 14.2 μM.Lopinavir waa antiretroviral ee fasalka protease inhibitor.Joojinta borotiinka HIV-1 waxay ka hortagtaa kala-goynta fayraska polyprotein-ka horudhaca ah waxayna keentaa sii-deynta virions aan qaan-gaarin, oo aan faafayn.Qayb ka mid ah daawaynta isku dhafan ee lagu daweynayo HIV/AIDS.Lopinavir, oo ah kii lixaad ee HIV protease inhibitor ee fasalka "navir", ayaa lagu bilaabay isku-duubnida ritonavir, oo ah HIV-ga kale oo horay loo suuq geeyey (Abbott, 1996);Habkan asalka ah waxaa loo soo bandhigay sida Kaletra si loogu isticmaalo isku-darka nucleoside ama non-nucleoside reverse transcriptase inhibitors ee daaweynta AIDS-ka ee dadka waaweyn iyo carruurta.Lopinavir waa iskudhis peptidomimetic ah oo leh xudunta qaabdhismeed la mid ah tan ritonavir, kaas oo kooxaha terminal, gaar ahaan valine la beddelay, lagu soo bandhigay hababka isku xidhka peptide.Lopinavir waa horjooge awood leh oo tartan u leh HIV-I protease oo muujinaya karti sare oo ka dhan ah isbeddellada u adkaysta ritonavir.Noocyo dhowr ah oo xayawaan ah, daraasado farmasokinetic ah oo lala yeeshay ururka lopinavirlritonavir ayaa muujiyay in sifooyinka suubban ee lopinavir ay si weyn u wanaajiyeen joogitaanka ritonavir, marka la eego Cmax iyo muddada ficilka.