Potassium Losartan CAS 124750-99-8 API Nadiifnimada Sare ee Kahortagga Dhiig-karka
Bixinta Potassium-ka Losartan iyo Dhex-dhexaadinta La Xidhiidha Tayada Sare leh
Potassium Losartan CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Magaca Kiimikada | Potassium Losartan |
| La mid ah | DuP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt. |
| Lambarka CAS | 124750-99-8 |
| Lambarka CAT | RF-API98 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C22H22ClKN6O |
| Miisaanka Molecular | 461.01 |
| Meesha dhalaalaysa | 263.0 ~ 265.0 ℃ |
| Solubility | Si Xor Ah Ugu Milmayn Biyaha iyo Methanol, Waxoogaa Ku Soluble gudaha Acetonitrile. |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ama ku dhawaad cad budada crystalline |
| Aqoonsiga A | Nuugista Infrared: Waa in uu la mid yahay Heerka Tixraaca |
| Aqoonsiga B | Nuugista Ultraviolet: Waa in uu la mid yahay Heerka Tixraaca |
| Tijaabi Potassium | Waa in uu ahaado mid Wanaagsan |
| Waxyaabaha Biyaha (KF) | ≤0.50% |
| Biraha culus | ≤10pm |
| Walxaha La Xiriira (HPLC) | |
| Xumaan Shaqsiyeed Kasta | ≤0.20% |
| Wadarta wasakhda | ≤0.50% |
| Xalalka Hadhaaga ah (GC) | |
| Cyclohexane | ≤0.10% |
| Khamriga isopropyl | ≤0.20% |
| Habka Qiimaynta/Falanqaynta | 98.5 ~ 101.0% (HPLC, waxaa lagu xisaabiyaa anhydrous, dareere-free) |
| N-Nitrosodiethylamine | ≤0.177pm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Cabbirka Qaybaha | 90% In ka yar 38 Microns |
| Nolosha shelf | 24 bilood |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API, Angiotensin II Qaboojiyaha Ka-hortagga Dhiig-karka |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Potassium Losartan waa ka ugu horreeya ee awoodda leh iyo xulashada aan peptide angiotensin II reseptor nooca 1 (AT1) antagonist loo soo bandhigay suuqa sida antihypertensive afka hal mar maalintii.Isku-duubnaanta xannibaysa 50% ee xidhitaanka angiotensin II (IC50) waa 20 nM.Losartan (40 μM) waxay saamaysaa ISC laakiin waxay ka hortagtaa saamaynta ANGII ee ISC.Losartan waxay si weyn u yaraynaysaa kororka unugyada Ang II ee dhexdhexaadinta unugyada kansarka endometrial.Isku darka losartan iyo anti-miR-155 waxay leedahay saameyn aad u weyn oo ka hortag ah marka loo eego daroogo kasta oo keliya.Waxaa la dheefshiido si loo soo saaro 5-carboxylic acid metabolite (EXP3174) waxaana lagu soo waramayaa inay hoos u dhigto cadaadiska dhiigga.Waxaa hadda loo baadhi karaa sidii daweyn suurtagal ah oo loogu talagalay COVID-19 awoodda ay u leedahay in la yareeyo ama ay suurtogal tahay in la yareeyo calaamadaha COVID-19.
1. Daawaynta dhiig-karka lagama maarmaanka ah, waxa loo isticmaali karaa kaligaa ama lagu daro dawooyinka kale ee ka hortagga hypertensive (sida diuretics).2. Daawaynta wadna xanuunka, waxa loo isticmaali karaa kaligaa ama marka lagu daro dawooyinka Kiimikada ee cardiotonic ama diuretic.3. Ka hortagga istaroogga ee bukaanka qaba hypertension iyo hypertrophy ventricular bidix.4. Waxaa loo isticmaalaa in lagu yareeyo horumarka nephropathy ee bukaanada qaba nooca 2 ee sonkorowga ee la xidhiidha nephropathy iyo hypertension.
