Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate CAS 328086-60-8 PF-07321332 Boceprevir Dhexdhexaadiyaha Sawirka

Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

Sharaxaad Gaaban:

Magaca Kiimikada: Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate

CAS: 328086-60-8

Muuqashada: Caddaan ilaa budo cad-cad

Dhexdhexaadiyaha PF-07321332 Paxlovid (CAS 2628280-40-8) iyo Boceprevir (CAS 394730-60-0)

Tayada Sare, Wax Soo Saarka Ganacsiga

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Sharaxaad:

Iibka Ganacsiga PF-07321332 Dhexdhexaadiyeyaasha la xidhiidha Paxlovid oo leh tayo Sare
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(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0] hexane CAS 943516-54-9

Guryaha Kiimikada:

Magaca Kiimikada	Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate
La mid ah	Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl) propanoate;(αS,3S)-α-[(tert-Butyloxycarbonyl) aMino]-2-oxo-3-pyrrolidinepropanoic acid Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl) propanoate
Lambarka CAS	328086-60-8
Lambarka CAT	RF-PI317
Heerka Saamiyada	Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram
Qaanuunka molecular	C13H22N2O5
Miisaanka Molecular	286.33
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Caddaan ilaa budo cad-cad
Aqoonsiga A	IR: La mid ah Walxaha Tixraaca
Aqoonsiga B	Waqtiga Haynta: Waxay la mid tahay Walaxda Tixraaca
Khasaare xagga qalajinta	≤1.0%
Hadhaaga dabka	≤0.20%
Xumaanta Keliya	≤0.50%
Wadarta wasakhda	≤2.0%
Biraha culus (Pb)	≤20pm
daahirnimo	≥98.0%
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	Dhexdhexaadiyaha PF-07321332 Paxlovid (CAS 2628280-40-8) iyo Boceprevir (CAS 394730-60-0)

Xidhmada & Kaydinta:

Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.

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Codsiga:

Methyl (S)-2-(Boc-amino) -3-[(S) -2-oxo-3-pyrrolidinyl] propanoate (CAS 328086-60-8) waa dhexdhexaadka PF-07321332 Paxlovid (CAS 2628280-40) -8) iyo Boceprevir (CAS 394730-60-0).PF-07321332, oo ah qaybta muhiimka ah ee Paxlovid (PF-07321332 iyo Ritonavir) oo ah baaritaanka COVID-19 ee musharaxa afka laga qaato, waa 3C-la mid ah protease (3CLPRO) inhibitor oo leh saameyn xoog leh oo ka hortag ah fayraska SARS-CoV-2 iyo COVID-19.Noofambar 6-deedii 2021, Pfizer wuxuu ku dhawaaqay in Paxlovid si weyn hoos ugu dhigay isbitaal dhigista iyo dhimashada, iyadoo lagu saleynayo falanqaynta ku meel gaadhka ah ee Wajiga 2/3 EPIC-HR (Qiimaynta Ka-hortagga Protease ee COVID-19 ee Bukaannada Khatarta Sarreya) oo aan kala sooc lahayn, laba indhoole Bukaannada qaangaarka ah ee aan isbitaalka la jiifin ee qaba COVID-19, kuwaas oo halis sare ugu jira inay u gudbaan jirro daran.Boceprevir (EBP-520) waa HCV protease inhibitor (Ki=14 nM) ee daawaynta caabuqa cagaarshow C.Boceprevir oo leh pegylated interferon iyo ribavirin (PegIFN/RBV) waxa ay suurta galisay horumar ku saabsan heerka jawaab celinta fayraska ee joogtada ah ee bukaanada qaba genotype 1 HCV.Boceprevir waxay la falgashaa daawaynta difaaca jirka (IT) iyadoo la joojinayo cytochrome P450 3A enzyme.