Molnupiravir (EIDD-2801) CAS 2349386-89-4 COVID-19 API Tayada Sare
Sahayda Ganacsi ee Molnupiravir iyo Dhexdhexaadiyayaasha la xidhiidha Tayada Sare leh
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Molnupiravir (EIDD-2801) CAS 2349386-89-4
| Magaca Kiimikada | Molnupiravir (EIDD-2801) |
| La mid ah | MK-4482;β-D-N4-Hydroxycytidine-5'-isopropyl ester;((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino) -2-oxo-3,4-dihydropyrimidin-1(2H) -yl) tetrahydrofuran-2 -yl) methyl isobutyrate |
| Lambarka CAS | 2349386-89-4 |
| Lambarka CAT | RF-API97 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C13H19N3O7 |
| Miisaanka Molecular | 329.31 |
| Solubility | Ku milmay DMSO |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ilaa budo cad-cad |
| Aqoonsiga IR | Muunad Spectrum waxay u dhigantaa heerka tixraaca |
| Aqoonsiga HPLC | Waqtiga haynta ee ugu sarreeya ee xalka muunadda ayaa u dhigma kan xalka caadiga ah |
| Walxaha laxidhiidha | |
| Xumaanta A | ≤0.15% |
| Xumaanta B | ≤0.15% |
| Najaasad kasta oo aan la cayimin | ≤0.15% |
| Wadarta wasakhda aan la cayimin | ≤0.30% |
| Wadarta wasakhda | ≤0.50% |
| Xalalka Haraaga ah | |
| N-Heptane | ≤5000ppm |
| Ethanol | ≤5000ppm |
| isopropyl acetate | ≤5000ppm |
| Acetonitrile | ≤410pm |
| Methylene Dichloride | ≤600pm |
| Acetone | ≤5000ppm |
| Isopropanol | ≤5000ppm |
| Waxyaabaha Biyaha (KF) | ≤0.50% |
| Hadhaaga dabka | ≤0.10% |
| Wareegga indhaha | -7.5° ilaa -9.5° (C=0.5, methanol) |
| Biraha culus | ≤10pm |
| Daahirnimada / Habka Falanqaynta | ≥99.5% (230nm) |
| Habka Qiimaynta / Falanqaynta | 98.0% ~ 102.0% (HPLC ku salaysan qalalan) |
| Nolosha shelf | 24 bilood |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API, Molnupiravir (EIDD-2801) Joojiyaha COVID-19 |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Molnupiravir (EIDD-2801, MK-4482) waa soosaar afka laga heli karo oo ka mid ah daawada ribonucleoside analooga β-d-N4-hydroxycytidine (NHC; EIDD-1931) oo leh hawlo fayrus ballaaran oo ka dhan ah SARS-CoV-2, MERS-CoV, SARS-CoV, iyo wakiilka keena COVID-19.Molnupiravir waxaa lagu iibiyaa magaca sumadda Lagevrio iyo guud ahaan sida emorivir.Molnupiravir ayaa la muujiyay in ay wanaajiso shaqada sambabada, hoos u dhigto miisaanka jidhka iyo in ay yarayso qadarka fayraska ee sambabada.Marka laga soo tago dhaqdhaqaaqa ka dhanka ah coronaviruses, Molnupiravir, ee daraasadaha shaybaarka, ayaa muujiyay waxqabad ka dhan ah hargabka xilliyeed iyo shimbiraha, fayraska syncytial neef-mareenka, fayraska chikungunya, fayraska Ebola, fayraska equine encephalitis ee Venezuela, iyo fayraska equine encephalitis bari.Molnupiravir waxaa markii hore loo sameeyay in lagu daweeyo hargabka Jaamacadda Emory waxaana iska leh shirkadda hal-abuurka dawooyinka ee jaamacadda, Drug Innovation Ventures at Emory (DRIVE), laakiin waxaa la sheegay in looga tagay arrimo la xiriira is beddelka.Waxaa markaas la wareegay shirkadda fadhigeedu yahay Miami ee Ridgeback Biotherapeutics, taasoo markii dambe iskaashi la sameysay Merck & Co. si ay u sii horumariso daawada.Molnupiravir waxaa loo oggolaaday isticmaalka caafimaadka Boqortooyada Ingiriiska Noofambar 2021.
