N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Tayada Sare
U keeni Nadiif Sarreysa iyo Tayo Deggan
Magaca Kiimikada: N (4)-Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
Metabolite firfircoon ee Molnupiravir, oo ah horjoogaha COVID-19 ee ballan qaadaya
| Magaca Kiimikada | N(4)-Hydroxycytidine |
| La mid ah | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Lambarka CAS | 3258-02-4 |
| Lambarka CAT | RF-PI309 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Kiiloogaraam |
| Qaanuunka molecular | C9H13N3O6 |
| Miisaanka Molecular | 259.22 |
| Meesha dhalaalaysa | 169.0 ~ 172.0 ℃ |
| Solubility | Ku milmay ilaa 100 mM gudaha DMSO iyo ilaa 50 mM oo biyo ah |
| Cufnaanta | 1.93±0.1 g/cm3 |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ilaa budo cad-cad |
| NMR | Waafaqsan Qaab-dhismeedka |
| Daahirnimada / Habka Falanqaynta | > 98% (HPLC) |
| Khasaare xagga qalajinta | ≤1.0% |
| Xumaanta Keliya | ≤0.50% |
| Biraha culus | ≤20pm |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Metabolite firfircoon ee Molnupiravir (EIDD-2801), ka hortagga COVID-19 |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
N(4) -Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) waa dheef-shiid kiimikaad firfircoon ee EIDD-2801, horjoogaha COVID-19 ee ballanqaadka ah.EIDD-1931 (NHC) waxa ay leedahay hawlo fayrus oo balaadhan oo ka dhan ah coronaviruses badan, oo ay ku jiraan SARS-CoV-2, MERS-CoV, SARS-CoV, iyo zoonotic group 2b ama 2c Bat-CoVs oo leh celcelis ahaan IC50 ee 0.15 μM, iyo sidoo kale awoodda korodhay ee ka dhanka ah koronafayras iska caabbinta isu-bedelka nucleoside analog inhibitor remdesivir.Jiirarka uu ku dhacay SARS-CoV ama MERS-CoV, labadaba ka-hortagga iyo maamulka daweynta ee Molnupiravir (EIDD-2801), soo-saar afka ah NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), hagaajinta shaqada sambabada , iyo hoos u dhaca titer fayraska iyo dhimista miisaanka jidhka.Hoos u dhaca wax soo saarka MERS-CoV gudaha vitro iyo in vivo ayaa lala xiriiriyay korodhka isbeddelka isbeddelka ee fayraska laakiin aan martigelinin unugga RNA, taageeraya habka mutagenesis dilaaga ah ee CoV.Awoodda NHC/EIDD-2801 ee ka dhanka ah coronaviruses-ka badan iyo bioavailability afka waxay muujineysaa awooddeeda suurtagalka ah ee ka hortagga fayraska ka hortagga SARS-CoV-2 iyo coronaviruses zoonotic mustaqbalka.
