Naproxen CAS 22204-53-1 daahirnimo>99.5% (HPLC)

Naproxen (CAS: 22204-53-1) waa dawo aan steroid ahayn anti-bararka, waa PG synthase inhibitor, kaas oo joojin kara prostaglandin synthetase, waxay leedahay saameyn xanuun iyo antipyretic oo muhiim ah, nuugista afka waa mid degdeg ah oo dhamaystiran, 2 si 4 saacadood ka dib qiyaasta, fiirsashada balasmadu waxay gaartaa heerka ugu sarreeya, dhiigga, in ka badan 99% waxay ku xidhan yihiin borotiinnada plasma, t1/2 waa 13 ilaa 14 saacadood, qiyaastii 95% ayaa laga soo saaraa kaadida oo leh prototype iyo metabolites.Waxa loo isticmaalaa daawaynta laabotooyinka iyo rheumatoid arthritis-ka, osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.waxa kale oo loo isticmaali karaa in lagu yareeyo xanuunka uu keeno murgacashada murqaha, qallafsanaanta, dhaawaca iyo dysmenorrhea.Laakiin waa in la ogaadaa in sida daawooyinka kale ee non-steroid anti-bararka, isla fal-celinta xun ee caloosha iyo mindhicirka halis ah ayaa dhici karta wakhti kasta marka la qaadanayo naproxen inta lagu jiro daawaynta, sidaas darteed bukaannada boogaha gastroduodenal firfircoon ayaa la deldelaa, bukaannada kale ee cudurrada caloosha iyo mindhicirka waa inay qaataan tan. dawada hoos timaada kormeer caafimaad oo dhow.Naproxen waxaa laga soo saaray 2-methoxynaphthalene iyo (+) -isomer oo lagu helay xallinta cinchonidine (61).Waxaa lagu soo bandhigay Maraykanka 1976-kii, iyo, daawo guud ahaan, waxay si joogto ah uga mid ahayd NSAID-yada caanka ah.Waxaa loo suuq geeyaa S- (+) -entiomer, laakiin waxaa xiiso leh, cusbada sodium ee (-) isomer sidoo kale waxay ku jirtaa suuqa Anaprox.Xakamaynta biosynthesis ee prostaglandin, waxay 12 jeer ka awood badan tahay aspirin, 10 jeer ka awood badan phenylbutazone, saddex ilaa afar jeer ka awood badan ibuprofen, iyo afar jeer ka awood badan fenoprofen, laakiin waxay ku dhowdahay 300 jeer ka awood yar indomethacin.