Paxlovid: waxa aan ka ognahay Pfizer's Covid-19 pill

Pfizer waxay FDA ka raadinaysaa ogolaanshaha isticmaalka degdega ah kiniinkeeda cusub ee Covid-19 ee ka hortagga fayraska Paxlovid.
La wadaag Maqaalka

Marka la eego ansixinta Merck antiviral molnupiravir ee UK, Pfizer waxay dejisay inay kaniinkeeda Covid-19 ka hesho, Paxlovid, suuqa.Toddobaadkan, daaweeyayaasha Mareykanka ayaa ka dalbaday ogolaanshaha isticmaalka degdega ah Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) musharaxa cusub ee kahortaga fayraska shaqsiyaadka qaba Covid-19 dhexdhexaad ilaa dhexdhexaad ah, kuwaas oo halis sare ugu jira isbitaal ama dhimasho. Pfizer ayaa sidoo kale leh wuxuu bilaabay nidaamka raadinta ogolaanshaha sharciyeynta ee wadamada kale oo ay ku jiraan UK, Australia, New Zealand iyo South Korea, waxayna qorsheynayaan inay xareeyaan codsiyo dheeraad ah. Sidee ayuu u shaqeeyaa Paxlovid? ritonavir, oo ah dawada ka hortagga retroviral ee dhaqan ahaan loo isticmaalo daawaynta HIV.Daawadu waxay carqaladaynaysaa ku-noqoshada SARS-CoV-2 ee jidhka iyada oo ku xidhan 3CL-la mid ah protease, enzyme muhiim u ah shaqada fayraska iyo taranka.
Marka loo eego falanqaynta ku meel gaadhka ah, Paxlovid waxay hoos u dhigtay halista Covid-19-ku-xiran ee cusbitaalka ama dhimashada 89% kuwa helay daawaynta saddex maalmood gudahooda ee calaamaduhu.Daawada waxaa la ogaaday inay aad waxtar u leedahay - kaliya 1% bukaannada helay Paxlovid ayaa isbitaal la dhigay maalintii 28 marka la barbar dhigo 6.7% kaqeybgalayaasha placebo - in tijaabadeeda Wajiga II/III la soo afjaray goor hore iyo soo gudbinta sharciyeynta ee FDA ayaa la xareeyay isla markiiba la filayo.Waxaa intaa dheer, iyadoo 10 dhimasho ah laga soo sheegay gacanta placebo, midna kama dhicin ka qaybgalayaasha qaatay Paxlovid.Sida molnupiravir, Paxlovid waxaa lagu maamulaa afka, taasoo la micno ah in bukaannada Covid-19 ay dawada ku qaadan karaan guriga marxaladaha hore ee caabuqa.Rajada ayaa ah in dawooyinka cusub ee ka-hortagga fayraska sida kuwa Merck iyo Pfizer ay u oggolaanayaan dadka qaba kiisaska khafiifka ah ama dhexdhexaadka ah ee coronavirus in si dhakhso ah loo daweeyo, ka hortagga horumarka cudurka iyo inay ka fogaadaan isbitaallada inay buux dhaafaan.

Tartanka dawooyinka Covid-19Merck's molnupiravir, oo ah kaniinkii ugu horreeyay ee loo oggolaaday Covid-19, ayaa lagu tiriyaa inuu wax ka beddeli karo ciyaarta tan iyo markii daraasadaha lagu ogaaday inay hoos u dhigtay isbitaallada iyo khatarta dhimashada qiyaastii 50%.Laakiin taasi macnaheedu maaha in bixinta Pfizer ee ka hortagga fayraska aysan ku yeelan doonin geeska suuqa.Falanqaynta ku meel gaadhka ah ee waxtarka molnupiravir ayaa ah mid rajo leh, laakiin khatarta khatarta ah ee ay soo tebisay Pfizer waxay muujinaysaa in kaniinkeedu uu sidoo kale caddayn karo hub qiimo leh oo ka mid ah hubka dawladda ee ka hortagga masiibada. fayraska xafiiltama.Khubarada qaar ayaa walaac ka muujiyay in habka molnupiravir ee ficilka ka dhanka ah Covid-19 - ku dayashada molecules RNA si ay u keento isbeddellada fayraska - ay sidoo kale soo saari karto isbeddellada waxyeellada leh ee DNA-da aadanaha.Paxlovid, oo ah nooc ka duwan fayraska loo yaqaan 'protease inhibitor', ma muujin wax calaamado ah "isdhexgalka DNA-da mutagenic", ayuu yiri Pfizer.