Olopatadine Hydrochloride Dhexdhexaad CAS 27710-82-3 daahirnimo>99.0% (HPLC)
Iibiyaha ugu horreeya ee Olopatadine Hydrochloride Intermediates
Olopatadine Hydrochloride CAS 140462-76-6
Isoxepac CAS 55453-87-7
[3- (Dimethylamino) propyl] triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
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| Magaca Kiimikada | [3- (Dimethylamino) propyl] triphenylphosphonium Bromide Hydrobromide |
| La mid ah | (3-Dimethylaminopropyl) triphenylphosphonium Bromide HBr |
| Lambarka CAS | 27710-82-3 |
| Lambarka CAT | RF2698 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C23H28Br2NP |
| Miisaanka Molecular | 509.27 |
| Meesha dhalaalaysa | 283.0 ~ 285.0 ℃ |
| Xasilooni | Hygroscopic |
| Solubility | Chloroform (wax yar), methanol (wax yar) |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Crystal White ilaa Cadaan |
| Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
| Habka Qiimaynta / Falanqaynta | >99.0% (Titration) |
| Khasaare xagga qalajinta | <0.50% |
| Xumaanta Keliya | <0.50% |
| Wadarta wasakhda | <1.00% |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyaha Olopatadine Hydrochloride (CAS: 140462-76-6) |
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[3- (Dimethylamino) propyl] triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) waa dhexdhexaadinta Olopatadine Hydrochloride (CAS: 140462-76-6).Olopatadine Hydrochloride waa dawada ka hortagga xasaasiyadda.Waxay leedahay saameynaha laba-geesoodka ah ee joojinta sii deynta histamine-ka iyo si door ah uga soo horjeeda HI reseptors, oo aan lahayn habdhiska dhexe ee neerfaha iyo saameynaha sunta ah ee wadnaha kuwaas oo caan ku ah daawooyinka xasaasiyadda HI receptor antagonist.Olopatadine Hydrochloride kaliya ma joojin karto sii deynta histamine ee unugyada mastarada, laakiin sidoo kale waxay ka soo horjeedaa H1 reseptors si ka duwan, wax saameyn ahna kuma yeelanayso α adrenergic reseptors, dopamine reseptors, iyo M1 iyo M2 reseptors.Waxaa ka mid ah, dhibaatooyinka soo raaca ee habka dhexe ee neerfayaasha waa yar yihiin, waa jiil cusub oo ah daawooyinka antiallergic doorashada.Olopatadine waa mid awood leh, antagonist xulashada H1 histamine reseptor (Ki = 16-41.1 nM), oo leh xiriir hoose oo hooseeya ee H2 iyo H3 reseptors (Ki = 43.4 iyo 172 μM, siday u kala horreeyaan).Waxay ka hortagtaa isbeddelka fosfoosinitide ee histamine-ku keeno unugyada go'doonsan (IC50 = 9.5-39.9 nM) waxayna ka hortagtaa anaphylaxis maqaarka aan caadiga ahayn ee jiirka (ED50 = 49 μg / kg) iyo bronchoconstriction anaphylactic ee doofaarka guinea (ID50 = 30).Olopatadine waxay wax ku ool u tahay daawaynta xasaasiyadda rhinitt iyo conjunctivitis.Waxa kale oo ay joojisaa cuncunka bukaanka qaba cudurka urtikaria ee daba-dheeraada ee si wanaagsan loo xakameeyay.Bini'aadamka, antihistamine-kan ma keeno garaadka ama cillad maskaxeed marka la eego qiyaasta daweynta.
