Phenyl (4- (4- (4-hydroxyphenyl)piperazin-1-yl) phenyl) carbamate CAS 184177-81-9 Posaconazole Dhexdhexaadiyaha Tayada Sare
Agab Warshada oo leh Nadiif Sarreysa iyo Tayo Deggan
Dhexdhexaadiyaha Ganacsiga ee Posaconazole ee la xidhiidha
Posaconazole CAS 171228-49-2
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Phenyl (4- (4- (4-hydroxyphenyl)piperazin-1-yl) phenyl) carbamate CAS 184177-81-9
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Magaca Kiimikada | Phenyl (4- (4- (4-hydroxyphenyl)piperazin-1-yl) phenyl) carbamate |
La mid ah | Posaconazole Intermediate |
Lambarka CAS | 184177-81-9 |
Lambarka CAT | RF-PI290 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C23H23N3O3 |
Miisaanka Molecular | 389.45 |
Cufnaanta | 1.296 |
Xaalada Maraakiibta | Heerkulka deegaanka hoostiisa |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Ciro Brown ilaa budada cawl |
Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) |
Khasaare xagga qalajinta | ≤0.50% |
Hadhaaga dabka | ≤0.20% |
Biraha culus | ≤20pm |
Xumaanta Keliya | ≤0.50% |
Wadarta wasakhda | ≤1.0% |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyaha Posaconazole (CAS 171228-49-2) |
Xidhmada: Dhalo, boorsada bireed aluminium, durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Phenyl (4- (4- (4-hydroxyphenyl)piperazin-1-yl) phenyl)carbamate (CAS 184177-81-9) waa Dhexdhexaadiyaha Posaconazole (CAS 171228-49-2).Posaconazole waa spectrum ballaaran, jiilka labaad, triazol oo leh waxqabad antifungal ah.Waxaa loo oggolaaday isticmaalka caafimaadka gudaha Mareykanka Sebtembar 2006, waxaana loo heli karaa daawo guud.Posaconazole waa daawada antifungal ee triazole oo lagu suuqgeeyo Maraykanka oo ay bixiso Schering-Plough oo hoos timaada magaca ganacsiga Noxafil.Posaconazole waxay u shaqeysaa iyada oo carqaladeyneysa xirmooyinka dhow ee silsiladaha acyl ee fosfoolipids, oo wiiqaya shaqooyinka hababka enzyme xuubka-ku xiran sida ATPase iyo ensaymes ee habka gaadiidka elektaroonigga ah, sidaas darteed xannibaya koritaanka fangaska.Tani waxay ku samaynaysaa iyada oo xannibaysa isku-dhafka ergosterol iyada oo la joojinayo enzyme lanosterol 14a-demethylase iyo ururinta horudhaca sterol methylated.