Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Warshada
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha iyo soo saaraha ugu horreeya ee Polymyxin B Sulfate (CAS: 1405-20-5) oo leh tayo sare.Waxaan bixin karnaa COA, gaarsiinta adduunka oo dhan, tiro yar iyo tiro badan oo la heli karo.Haddii aad xiisaynayso Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Polymyxin B Sulfate |
| La mid ah | Polymyxin B Sulfate Salt;Aerosporin;Mastimyxin;PXNS;PMB;Poly-RX |
| Heerka Saamiyada | Kaydka dhexdiisa, Awoodda Wax-soo-saarka 10 Tan sannadkii |
| Lambarka CAS | 1405-20-5 |
| Qaanuunka molecular | C55H96N16O13·2H2SO4 |
| Miisaanka Molecular | 1301.56 |
| Meesha dhalaalaysa | 217.0 ~ 220.0 ℃ (dac.) |
| Xasaasi ah | HygroscopicXasaasi u ah Iftiinka iyo Kulaylka |
| Biyuhu milmayn | Ku milmay Biyaha, 50 mg/mL.Wax yar oo ku milma Ethanol |
| COA & MSDS | La heli karo |
| Tusaale | La heli karo |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Cadaan ama Ku dhawaad oo leh budada crystalline | waafaqsan |
| Aqoonsiga A. Waqtiyada xajinta ee ugu sarreeya ee ugu sarreeya ee xalka muunada waxay u dhigmaan kuwa xalka caadiga ah, sida lagu helay baaritaanka halabuurka Polymyxins. | waafaqsan | |
| PH (2%) | 5.0 ~ 7.0 | 5.7 |
| PH (0.5%) | 5.0 ~ 7.5 | 5.5 |
| Sulfated Ash | ≤0.75% |
|
| Wareeg gaar ah [α]20/D | -78.0°~-90.0°(C=2, H2O) (Calcd. on Anh. Substance) | -85.0° |
| Sulfate | 15.5 ~ 17.5% | 16.65% |
| Khasaare xagga qalajinta | ≤6.00% | 3.0% |
| Hadhaaga dabka | ≤0.10% | 0.02% |
| Biraha culus | ≤20pm | ≤20pm |
| Phenylalanine | 9.0 ~ 12.0% | 9.8% |
| Wadarta tirada Viabel Aerobic | ≤10cfu/g | ≤10cfu/g |
| Walxaha laxidhiidha, HPLC |
|
|
| Xumaanta Shaqsiga ah | ≤3.0% | 2.723% |
| Wadarta wasakhda | ≤17.0% | 16.223% |
| Assay HPLC (ODB) | Isku darka Polymyxins B1, B2, B3 iyo B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| Qiimayn, Microbiological (sida uu yahay) | ≥6500lU/mg | 8255IU/mg |
| Cabbirka Qaybaha | ≥99.0% ≤30um vol | waafaqsan |
| ≥90.0% ≤25um vol | ||
| ≥75.0%≤20um vol | ||
| ≥35.0%≤10um vol | ||
| Gabagabo | Alaabta ayaa u hoggaansan USP42 |
|
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Calaamadaha Khatarta Xn - Waxyeelo leh
Xeerarka Khatarta 22 - Waxyeelo leh haddii la liqo
Sharaxaada Badbaadada S22 - Ha neefsan boorka.
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Aqoonsiga Qaramada Midoobay 3249
WGK Germany 3
RTECS TR1150000
FLUKA BRAND F CODES 3-8-10
HS code 2941909099
Khatarta Fasalka 6.1(b)
Kooxda Baakadaha III
Polymyxin waa koox ka mid ah antibiyootiga polypeptide ee uu soo saaro Bacillus polymyxa (bacilluspolymyxa).Polymyxin B iyo E waxaa loo isticmaalaa ujeeddooyin daawo, sulfate-koodana waa la isticmaalaa.Bakteeriyada bakteeriyada iyo codsiga kiliinikada ee Polymyxin B Sulfate waxay la mid yihiin kuwa polymyxin E. Waxay leedahay saameyn liddi ku ah ama bakteeriyada bakteeriyada gram-negative, sida Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis iyo Shigella.
Polymyxin Sulfate B waxay la mid tahay polymyxin e, waxayna leedahay saameyn ka hortag ah ama bakteeriyada bakteeriyada gram-negative bacilli, sida e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis iyo bacilli dysentery.Waxaa inta badan loo isticmaalaa boogaha, kaadi mareenka, isha, dhegta, trachea iyo qaybaha kale ee caabuqa ee ay keento Pseudomonas aeruginosa iyo Pseudomonas kale.Waxa kale oo loo isticmaali karaa sepsis iyo peritonitis.Iyo infekshannada daran ee ay keenaan aminoglycosides, bakteeriyada cephalosporin-jiilka saddexaad ee u adkaysta, Pseudomonas aeruginosa ama bakteeriyada kale ee xasaasiga ah, sida bakteeriyada, endocarditis, oof-wareen, caabuqa gubashada kadib, iwm.
1. Faleebo xididka: dadka waaweyn iyo carruurta leh shaqada caadiga ah ee kelyaha 1.5 ~ 2.5mg halkii kiilogaraam ee miisaanka jidhka (guud ahaan aan ka badnayn 2.5mg kiilooga miisaanka jidhka) 1 maalin, oo loo qaybiyo 2 jeer, dhibicyo hal mar 12 saacadoodba.50mg kasta oo alaabtan ah waxaa lagu qasi jiray 500ml oo ah 5% xal gulukoos ah ka dibna waa la tifqaaya.Dhallaanka leh shaqada caadiga ah ee kelyaha waxay u dulqaadan karaan 4mg halkii kiilo ee miisaanka jidhka 1 maalin.2. Duritaan muruqa ah: dadka waaweyn iyo carruurta: 2.5 ~ 3mg halkii kiilogaraam ee miisaanka jidhka ee 1aad, oo lagu bixiyo qaybo, hal mar 4 ~ 6 saacadood.Dhallaanku waxay gaari karaan 4mg halkii kiilo ee miisaanka jirka maalintiiba halka dhallaanka cusub ay gaari karaan 4.5mg kiiloga miisaanka jirka.3. Duritaan gudaha ah (oo loogu talagalay Pseudomonas aeruginosa meningitis): 5mg halkii millilitir ee daawada dareeraha ah oo lagu diyaariyey duritaanka sodium chloride.Dadka waaweyn iyo carruurta da'doodu ka weyn tahay 2 sano, 5mg maalin kasta, ka dib 3-4 maalmood codsiga, beddelo hal mar maalin kasta, ugu yaraan 2 toddobaad, ilaa dhaqanka dareeraha cerebrospinal waa xun, iyo content sonkorta waa caadi.Carruurta da'doodu ka yar tahay 2 sano, isticmaal 2mg maalintii hal mar 3-4 maalmood oo isku xigta (ama 2.5mg hal mar maalin kasta), ka dibna isticmaal 2.5mg hal mar maalin kasta ilaa baaritaanku caadi noqdo.4. Xakamaynta dhibcaha indhaha waa 1 ~ 2.5mg halkii ml.
Iska ilaali inaad ku darto daawooyinka dhaawaca kelyaha, nasinta murqaha lafaha, antibiyootiga aminoglycoside, suuxinta leh saamaynta nasashada muruqa cad (sida enflurane), iwm, iyo quinine, magnesium, iwm. lama isticmaali karo xididada isku mar.Polymyxin B sulfate waxaa lagu daraa sulfonamides, rifampicin, penicillin semi-synthetic, iwm.,
1, Haweenka uurka leh iyo kuwa nuujinaya, carruurta, iyo bukaanada qaba kelyo la'aan daran ayaa aad u badan.2. Alaabtani aad bay sun u tahay waxayna leedahay saamayn daawaynta liidata ee caabuqa unugyada qoto dheer.Ma aha doorashada koowaad ee caabuq kasta.3. Cirbadka xididka ayaa laga yaabaa inuu keeno niyad-jabka neefsashada, taas oo aan guud ahaan la isticmaalin.Ugu yaraan nus ka mid ah qiyaasta maalinlaha ah waxay u baahan tahay faleebo faleebo ah, ma aha bolus degdeg ah hal mar, si looga fogaado xannibaad ballaaran oo neuromuscular ah.4. Waa inaan lagu darin dawooyinka kale ee leh nephrotoxicity ama xannibaadda neuromuscular si looga fogaado shilalka.
Cilmi-baarista biochemical.Polymyxin B waa anti-gram-negative bacilli polypeptide antibiyootiga, kaas oo bedeli kara qaabka xuubka si uu u daadiyo molecules yaryar oo uu joojiyo koritaanka bakteeriyada garaam-negative.Waxay leedahay saameyn bakteeriyada Escherichia coli.Lipid A unugyo ku xidhan bakteeriyada lipopolysaccharides.Daloollo yaryar ayaa ka soo baxa xuubka unugga maqaarka ee dibadda.Habka ficilka: waxay xidhaa oo faragelisaa qulqulka xuubka cytoplasmic.Bakteeriyada ka hortagga bakteeriyada: bakteeriyada Gram-negative.
Polymyxin B, Sulfate.
Polymyxin B Sulfate [1405-20-5].
» Polymyxin B Sulfate waa milixda sulfate ee nooc ka mid ah polymyxin, walax ay soo saarto koritaanka Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), ama isku dar ah laba ama in ka badan oo cusbo ah.Waxay leedahay awood aan ka yarayn 6000 Polymyxin B Units halkii mg, oo lagu xisaabiyo sal engegan.
Baakadaha iyo kaydinta-Ku xafid weelasha cidhiidhiga ah, iftiinka u adkaysta.
Calaamadeynta-Halka baakadaha loogu talagalay isku-darka daawada, calaamaddu waxay sheegaysaa tirada Polymyxin B Units ee ku jirta weelka iyo halkii milligaraam, in aan loogu talagelin isticmaalka wax-soo-saarka, in aan nadiif ahayn, iyo inaan awooddeeda la hubin karin in ka badan 60 maalmo kadib furitaanka.Meesha loogu talagalay in loogu isticmaalo diyaarinta foomamka qiyaasaha la isku duro ama kuwa kale ee nadiifka ah, calaamaddu waxay sheegaysaa in ay nadiif tahay ama ay tahay in la marsiiyo habayn dheeraad ah inta lagu jiro diyaarinta foomamka qiyaasta qiyaasta la isku duro ama kale.
Heerarka Tixraaca USP <11>-
USP Polymyxin B Sulfate RS
Aqoonsiga -
A: Tijaabada Aqoonsiga Chromatographic ee dareeraha ah-
Marxaladda wareegta- Diyaari isku dhafka 0.1 M tribasic sodium phosphate iyo acetonitrile (77:23), oo ku hagaaji fosfooraska acid pH ah 3.0.Samee hagaajin haddii loo baahdo (eeg Habboonaanta Nidaamka ee hoos timaada Chromatography <621>.
Xalka caadiga ah-U diyaari xalka USP Polymyxin B Sulfate RS ee wajiga mobilada oo leh uruurin qiyaastii 3.5 mg halkii ml.Ka ilaali xalkan iftiinka.
Tijaabi xalka-U diyaari xalka Polymyxin B Sulfate ee wejiga mobilada isagoo ku urursan qiyaastii 3.5 mg halkii ml.Ka ilaali xalkan iftiinka.
Nadaamka Chromatographic (eeg Chromatography <621>)-Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay 212-nm baaraha iyo tiir 4.6-mm × 25-cm ah oo ka kooban 5-µm xirmo L1.Heerka socodka waa qiyaastii 1 mL daqiiqadii.
Habka- gooni u duri mugga isle'eg (qiyaastii 10 µL) ee xalka caadiga ah iyo xalka tijaabada chromatograph-ka, oo duub chromatogram-yada.chromatogram-ka laga helay xalka Tijaabada wuxuu u dhigmaa si tayo leh kan laga helay xalalka Heerka, isagoo muujinaya heerka ugu sarreeya ee u dhigma polymyxin B1 iyo ugu sarreeya waqtiyada xajinta ee qiyaastii 0.5 (polymyxin B2) iyo 0.6 (polymyxin B3).
B: Ku milmo 2 mg 5 mL oo biyo ah, ku dar 5 mL oo ah 2.5 N sodium hydroxide, isku dar, ku dar 5 dhibcood oo koob sulfate ah (1 100), rux ka dib marka lagu daro dhibic kasta: midab casaan ah oo casaan ah ayaa la soo saaraa. .
C: Xalka (1 ee 20) ayaa buuxinaya shuruudaha imtixaannada Sulfate <191>.
pH <791>: inta u dhaxaysa 5.0 iyo 7.5, xal ka kooban 5 mg halkii ml.
Luminta qalajinta <731> -ku qallaji qiyaastii 100 mg, si sax ah loo miisaamay, dhalada xididka joogsan ee faakuumka 60℃ 3 saacadood: waxay luminaysaa wax aan ka badnayn 7.0% miisaankeeda.
Waxyaabaha ay ka kooban tahay phenylalanine-Ku wareeji qiyaastii 0.375 g Polymyxin B Sulfate, si sax ah loo miisaamay, ilaa 100-mL weel mug leh, ku milmi oo ku milmaan 0.1 N hydrochloric acid si mug ah, oo isku qas.Cabir nuugayaasha xalkan ugu badnaan qiyaastii 264 nm (A264), 258 nm (A258), iyo 252 nm (A252), nuugista 280 nm (A280) iyo 300 nm (A300).Xisaabi boqolkiiba phenylalanine ee qaybta Polymyxin B Sulfate ee ay qaadatay qaacidada:
(9.4787/W)(A258 - 0.5A252 + 0.5A264 - 1.84A280 + 0.8A300)
kaas oo W uu yahay miisaanka, g, ee Polymyxin B Sulfate ee la qaatay: waxa uu ka kooban yahay inta u dhaxaysa 9% iyo 12% ee phenylalanine, oo lagu xisaabiyo sal engegan.
Shuruudaha kale- Haddii loogu talagalay isku-darka daawada, waxay buuxinaysaa shuruudaha hadhaaga dabka ee hoos yimaada Polymyxin B ee duritaanka.Halka calaamaddu ay sheegayso in Polymyxin B Sulfate ay tahay madhalays, waxay buuxinaysaa shuruudaha Imtixaannada Dhalmo-dhalaysnimada <71> iyo, halka loogu talagalay foomamka qiyaasta qiyaasta la isku duro, ee Pyrogen ee hoos yimaada Polymyxin B ee duritaanka.Meesha calaamaddu ku qoran tahay in Polymyxin B Sulfate ay tahay in lagu sameeyo habayn dheeraad ah inta lagu jiro diyaarinta foomamka qiyaasta qiyaasta la isku duro, waxay buuxinaysaa shuruudaha Pyrogen ee hoos yimaada Polymyxin B ee duritaanka.
Imtixaan-ku-sii wad Polymyxin B Sulfate sida lagu faray Antibiyootig-Badhida-qeybiyeyaasha <81>.
