Posaconazole CAS 171228-49-2 API Warshada Triazole Wakiilka Antifungal Tayada Sare
Bixinta Warshada Posaconazole Dhexdhexaadiyeyaasha la xidhiidha, Wax soo saarka Ganacsiga
Posaconazole CAS 171228-49-2
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Magaca Kiimikada | Posaconazole |
La mid ah | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5- (1,2,4-triazol-1-ylmethyl) oxolan-3-yl] methoxy]phenyl] piperazin-1-yl] phenyl] -2-[(2S,3S) -2-hydroxypentan-3-yl] -1,2,4-triazol-3-hal |
Lambarka CAS | 171228-49-2 |
Lambarka CAT | RF-API77 |
Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
Qaanuunka molecular | C37H42F2N8O4 |
Miisaanka Molecular | 700.78 |
Cufnaanta | 1.36 g/cm3 |
Solubility | Ku milmay DMSO, Biyuhu ku milmi karin |
Xaalada Maraakiibta | Lagu soo raray Heer kulka jawiga |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Aqoonsiga A | IR: Noocyada nuugista infrared-ka ee alaabtu waa inay la socotaa tan walaxda tixraaca |
Aqoonsiga B | Waqtiga haynta HPLC oo la mid ah walaxda tixraaca |
Meesha dhalaalaysa | 167.0 ~ 171.0 ℃ |
Wareeg gaar ah [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Biyaha (KF) | ≤1.0% |
Hadhaaga dabka | ≤0.10% |
Walxaha laxidhiidha | |
HT 909-24 | ≤0.20% |
Xumaan Shaqsiyeed Kasta | ≤0.10% |
Wadarta wasakhda | ≤1.0% |
Xalalka Haraaga ah | |
Methanol | ≤3000pm |
Methyl tert-Butyl Ether | ≤5000ppm |
Isopropanol | ≤5000ppm |
Dimethyl Sulfoxide | ≤5000ppm |
Dichloromethane | ≤600pm |
Qiimayn | 98.0% ~ 102.0% (waxaa lagu xisaabiyaa habka qalalan) |
Biraha culus | ≤10pm |
Isomer | Enantiomer ≤0.10% |
Xumaan Shaqsiyeed kasta ≤0.10% | |
Wadarta wasakhda ≤1.0% | |
Heerka Imtixaanka | Heerka Ganacsiga;USP;BP;Heerka EP |
Isticmaalka | API, Triazole Agent Antifungal |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Posaconazole (CAS 171228-49-2), waa spectrum ballaaran, jiilka labaad, triazol oo leh firfircooni antifungal, oo laga bilaabay UK, waa xubinta ugu cusub ee fasalka azole ee wakiilada fangas si ay u gaarto suuqa.Waxaa loo tilmaamaa daaweynta iyo kahortaga cudurrada fangas-ka-soo-baxa ee kala duwan, oo ay ku jiraan aspergillosis, fusariosis, chromoblastomycosis, mycetoma, iyo coccidiomycosis ee bukaanada u diida, ama u dulqaadan karin, daaweynta caadiga ah ee amphotericin B iyo/ama itraconazole.Dalka Maraykanka, waxa loo oggolaaday ka-hortagga caabuqyada Aspergillus iyo Candida ee bukaannada da'doodu tahay 13 sano kuwaas oo halis sare ugu jira inay qaadaan caabuqyadan sababtoo ah si aad ah u difaacid.Intaa waxaa dheer, waxaa loo oggolaaday daawaynta candidiasis oropharyngeal.Posaconazole waxay leedahay hawlo ballaadhan oo ka sarreeya xubnaha kale ee antifungal azole.Marka lagu daro dhaqdhaqaaqa xoogga leh ee ka soo horjeeda kiisaska refractory ee aspergillosis iyo Candida u adkaysta fluconazole, waxay muujinaysaa firfircoonida ka dhanka ah Zygomycetes.Posaconazole waa daawada antifungal ee triazole oo lagu suuqgeeyo Maraykanka oo ay bixiso Schering-Plough oo hoos timaada magaca ganacsiga Noxafil.